Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer

PHASE3TerminatedINTERVENTIONAL
Enrollment

119

Participants

Timeline

Start Date

March 31, 2012

Primary Completion Date

October 31, 2014

Study Completion Date

January 13, 2015

Conditions
Prostate CancerCastration Resistant Prostate CancerPainProstatic Neoplasms
Interventions
DRUG

cabozantinib

Tablets taken orally once daily.

DRUG

mitoxantrone

Given by IV once every 3 weeks.

DRUG

prednisone

Taken twice a day orally by mouth. Commercially-obtained prednisone tablets will be over-encapsulated in order to blind identity.

Trial Locations (82)

7

Dublin

24

Dublin

2010

Darlinghurst

2031

Randwick

2076

Wahroonga

2139

Concord

2217

Kogarah

2444

Port Macquarie

3128

Box Hill

3690

Wodonga

4064

Milton

4101

South Brisbane

4102

Woolloongabba

10019

New York

10022

New York

10065

New York

14263

Buffalo

15232

Pittsburgh

20037

Washington D.C.

21231

Baltimore

23502

Norfolk

27516

Chapel Hill

27607

Raleigh

27710

Durham

30607

Athens

33486

Boca Raton

37203

Nashville

38120

Memphis

38801

Tupelo

40202

Louisville

44195

Cleveland

46202

Indianapolis

48201

Detroit

48202

Detroit

52242

Iowa City

53226

Milwaukee

53705

Madison

55455

Minneapolis

57201

Watertown

60611

Chicago

63110

St Louis

66025

Westwood

68198

Omaha

70112

New Orleans

73104

Oklahoma City

75246

Dallas

78681

Round Rock

80012

Aurora

80122

Littleton

84112

Salt Lake City

85258

Scottsdale

89109

Las Vegas

90024

Los Angeles

90073

Los Angeles

90292

Marina del Rey

92093

La Jolla

92123

San Diego

93105

Santa Barbara

94115

San Francisco

94305

Stanford

98104

Seattle

Unknown

New Brunswick

Subiaco

Belfast

V1Y 5L3

Kelowna

V57 4E6

Vancouver

N6A 4L6

London

M4N 3M5

Toronto

M5G 2M9

Toronto

BA1 3NG

Bath

CB2 0QQ

Cambridge

LS9 7TF

Leeds

NW1 2PG

London

SE1 9RT

London

W12 0HS

London

M20 4BX

Manchester

CH63 4JY

Metropolitan Borough of Wirral

SM2 5PT

Sutton

AB25 2ZN

Aberdeen

EH4 2XU

Edinburgh

G12 0YN

Glasgow

RO17

Inverness

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Exelixis

INDUSTRY