Study of Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy in Patients With Stage III Non-small Cell Lung Cancer

PHASE2UnknownINTERVENTIONAL
Enrollment

138

Participants

Timeline

Start Date

February 22, 2012

Primary Completion Date

August 17, 2020

Study Completion Date

August 1, 2021

Conditions
Stage III Lung Non-Small Cell Cancer AJCC v7Stage IIIA Lung Non-Small Cell Cancer AJCC v7Stage IIIB Lung Non-Small Cell Cancer AJCC v7
Interventions
DRUG

18F-Fluoromisonidazole

Undergo FMISO PET/CT (Correlative studies)

DRUG

Carboplatin

Given IV

PROCEDURE

Computed Tomography

Undergo FDG PET/CT

PROCEDURE

Computed Tomography

Undergo FMISO PET/CT (Correlative studies)

RADIATION

External Beam Radiation Therapy

Undergo radiotherapy

DRUG

Fludeoxyglucose F-18

Undergo FDG PET/CT

RADIATION

Image-Guided Adaptive Radiation Therapy

Undergo individualized adaptive radiotherapy

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Paclitaxel

Given IV

PROCEDURE

Positron Emission Tomography

Undergo FDG PET/CT

PROCEDURE

Positron Emission Tomography

Undergo FMISO PET/CT (Correlative studies)

Trial Locations (31)

10065

Memorial Sloan Kettering Cancer Center, New York

10591

Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow

10604

Memorial Sloan Kettering Westchester, Harrison

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

19111

Fox Chase Cancer Center, Philadelphia

19140

Temple University Hospital, Philadelphia

19611

Reading Hospital, West Reading

29425

Medical University of South Carolina, Charleston

30912

Augusta University Medical Center, Augusta

39216

University of Mississippi Medical Center, Jackson

40202

The James Graham Brown Cancer Center at University of Louisville, Louisville

44106

Case Western Reserve University, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44131

Cleveland Clinic Cancer Center Independence, Independence

44136

Cleveland Clinic Cancer Center Strongsville, Strongsville

44195

Cleveland Clinic Foundation, Cleveland

44691

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Hospital and Clinics, Madison

60612

Rush University Medical Center, Chicago

63110

Washington University School of Medicine, St Louis

64111

Saint Luke's Hospital of Kansas City, Kansas City

73104

University of Oklahoma Health Sciences Center, Oklahoma City

94304

Stanford Cancer Institute Palo Alto, Palo Alto

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

H2W 1S6

McGill University Department of Oncology, Montreal

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH