Study Evaluating Efficacy And Tolerability Of Veliparib in Combination With Temozolomide (TMZ) or In Combination With Carboplatin and Paclitaxel Versus Placebo in Participants With Breast Cancer Gene (BRCA)1 and BRCA2 Mutation and Metastatic Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

294

Participants

Timeline

Start Date

January 23, 2012

Primary Completion Date

December 13, 2018

Study Completion Date

September 2, 2020

Conditions
Metastatic Breast Cancer
Interventions
DRUG

Placebo

DRUG

Veliparib

DRUG

Carboplatin

DRUG

Temozolomide

DRUG

Paclitaxel

Trial Locations (120)

1106

Bajcsy-Zsilinszky Korhaz /ID# 65179, Budapest

1200

Cliniques Universitaires Saint Luc /ID# 96135, Woluwe-Saint-Lambert

1884

Coiba /Id# 65219, Berazategui, Buenos Aires

2031

The Prince of Wales Hospital /ID# 63271, Randwick

2100

Rigshospitalet, Finsen Centre /ID# 67822, Copenhagen

2500

Southern Medical Day Care Ctr /ID# 63274, Wollongong

2650

UZ Antwerp /ID# 96945, Edegem

3000

ISIS Centro Especializado /ID# 65226, Santa Fe

Peter MacCallum Cancer Ctr /ID# 63272, Melbourne

UZ Leuven /ID# 96138, Leuven

3050

Royal Melbourne Hospital /ID# 63278, Parkville

4032

Debreceni Egyetem Klinikai Kozpont /ID# 65178, Debrecen

4101

Mater Misericordiae Limited /ID# 63276, South Brisbane

5000

Royal Adelaide Hospital /ID# 63280, Adelaide

CHU UCL Namur /ID# 110595, Namur

5004

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz /ID# 63928, Szolnok

5021

Haukeland University Hospital /ID# 67982, Bergen

6000

Mount Hospital /ID# 65262, Perth

Grand Hôpital de Charleroi /ID# 96136, Charleroi

7000

Royal Hobart Hospital /ID# 63279, Hobart

7100

Vejle Sygehus /ID# 65173, Vejle

8000

AZ St-Jan Brugge-Oostende AV /ID# 107315, Bruges

10003

Beth Israel Medical Center /ID# 87993, New York

13273

Institut Paoli-Calmettes /ID# 65175, Marseille

15260

University of Pittsburgh MC /ID# 60758, Pittsburgh

University of Pittsburgh MC /ID# 65486, Pittsburgh

17033

Penn State University and Milton S. Hershey Medical Center /ID# 62723, Hershey

17176

Karolinska Univ Sjukhuset /ID# 98037, Solna

18000

Cherkassy Regional Onc Ctr /ID# 97698, Cherkasy

21287

Johns Hopkins University /ID# 60759, Baltimore

28007

Hospital General Universitario Gregorio Maranon /ID# 97417, Madrid

28050

Hospital Universitario HM Sanchinarro /ID# 97416, Madrid

29010

Hospital Universitario Virgen de la Victoria /ID# 97976, Málaga

29425

Medical University of South Carolina /ID# 60752, Charleston

31059

Hopital Universitaire Purpan /ID# 98815, Toulouse

33308

Holy Cross Hospital /ID# 62995, Fort Lauderdale

33401

Florida Cancer Specialists - East /ID# 60762, West Palm Beach

33486

Lynn Cancer Institute, Boca /ID# 60749, Boca Raton

33521

Tampere University Hospital /ID# 102417, Tampere

35233

University of Alabama at Birmingham - Main /ID# 62994, Birmingham

36011

Poltava Regional Clinical Oncology Centre of Poltava Regional Council /ID# 97697, Poltava

38120

The West Clinic /ID# 65487, Memphis

The West Clinic /ID# 94599, Memphis

The West Clinic /ID# 94600, Memphis

40022

Municipal Non-Profit Enterprise of Sumy Regional Council Sumy Regional Clinical /ID# 65280, Sumy

44805

Institut de Cancer de l'Ouest /ID# 63927, Saint-Herblain

46010

Hospital Clinico Universitario de Valencia /ID# 97975, Valencia

49102

Municipal Non-Profit Enterprise City Clinical Hospital No.4 of Dnipro City Counc /ID# 63940, Dnipro

60099

Midwestern Regional CTC /ID# 60744, Zion

60607

University of Illinois - Chicago /ID# 106175, Chicago

60612

Rush University Medical Center /ID# 65489, Chicago

61070

Communal non-profit enterprise Regional Center of Oncology /ID# 97696, Kharkiv

63110

Washington University-School of Medicine /ID# 62724, St Louis

64100

Pays-Basque Ctr Oncology/Radio /ID# 65176, Bayonne

65026

Odessa National Medical Univ /ID# 65278, Odesa

67065

Centre Paul Strauss /ID# 100275, Strasbourg

69373

Centre Leon Berard /ID# 106675, Lyon

70300

Assaf Harofeh Medical Center /ID# 65181, Be’er Ya‘aqov

72205

University of Arkansas for Medical Sciences /ID# 60750, Little Rock

75248

Institut Curie /ID# 63926, Paris

76100

Kaplan Medical Center /ID# 63933, Rehovot

77030

Houston Methodist Hospital - Scurlock Tower /ID# 60742, Houston

79031

Lviv Oncological Regional Therapeutical and Diagnostic Centre /ID# 63941, Lviv

80045

Univ of Colorado Cancer Center /ID# 60751, Aurora

84101

Soroka University Medical Center /ID# 65180, Beersheba

85234

Banner MD Anderson Cancer Ctr /ID# 118695, Gilbert

90025

The Angeles Clinic and Researc /ID# 60743, Los Angeles

90048

Cedars-Sinai Medical Center - West Hollywood /ID# 60760, West Hollywood

91031

Shaare Zedek Medical Center /ID# 116575, Jerusalem

91120

Gastroenterology Institute, Division of Medicine /ID# 63931, Jerusalem

92093

Moore UC San Diego Cancer Center /ID# 60754, La Jolla

92210

Hopital Rene Huguenin /ID# 65177, Saint-Cloud

115478

Federal State Budgetary Scientific Institution N.N. Blokhin Russian Cancer Resea /ID# 65263, Moscow

183047

"State Regional Budgetary Healthcare Institution Murmansk Regional Oncology Dis /ID# 102415", Murmansk

197183

Birch A Healthcare /ID# 65265, Saint Petersburg

197758

N.N. Petrov Research Inst Onc /ID# 65269, Saint Petersburg

N.N. Petrov Research Inst Onc /ID# 78973, Saint Petersburg

200385

Sc Oncolab Srl /Id# 96745, Craiova

357502

Pyatigorsk Oncology Dispensary /ID# 65264, Pyatigorsk

400006

Spitalul Clinic Judetean de Urgenta /ID# 96741, Cluj-Napoca

400010

Inst Oncology Prof. Chiricuta /ID# 96740, Cluj-Napoca

404130

Volgograd Reg Onc Disp #3 /ID# 98035, Volzhsky

454087

Chelyabinsk Reg Clin Oncology /ID# 63938, Chelyabinsk

630075

City Clinical Hospital 1 /ID# 102416, Novosibirsk

3109601

Rambam Health Care Campus /ID# 63930, Haifa

4941492

Rabin Medical Center /ID# 63929, Petakh Tikva

5239424

Sheba Medical Center /ID# 63932, Ramat Gan

94305-2200

Stanford University School of Med /ID# 65488, Stanford

33612-9416

Moffitt Cancer Center /ID# 60746, Tampa

60611-2927

Northwestern University Feinberg School of Medicine /ID# 60755, Chicago

02114

Massachusetts General Hospital /ID# 64582, Boston

02215

Dana-Farber Cancer Institute /ID# 93833, Boston

48073-6710

William Beaumont Hospital /ID# 95417, Royal Oak

10065-6007

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 63222, New York

27710-3000

Duke University Medical Center /ID# 60747, Durham

19104-5502

University of Pennsylvania /ID# 60753, Philadelphia

75390-7208

UT Southwestern Medical Center /ID# 60745, Dallas

95900-000

Hospital Bruno Born / Sociedade Beneficencia e Caridade de Lajeado /ID# 65247, Lajeado

90020-090

Irmandade da Santa Casa de /ID# 65244, Porto Alegre

90035-903

Hospital de Clinicas de Porto Alegre /ID# 65242, Porto Alegre

M4N 3M5

Sunnybrook Health Sciences Ctr /ID# 77373, Toronto

H2X 0A9

CHUM - Notre-Dame Hospital /ID# 67862, Montreal

H3T 1E2

Jewish General Hospital /ID# 69893, Montreal

G1S 4L8

CHUQ-Hospital St. Sacrement /ID# 68902, Québec

656 53

Masarykuv onkologicky ustav /ID# 65170, Brno

779 00

Palacky University /ID# 63923, Olomouc

128 08

Vseobecna Fakultni Nemocnice /ID# 65172, Prague

00180

Docrates Cancer Center /ID# 63924, Helsinki

3015 CE

Erasmus Medisch Centrum /ID# 96275, Rotterdam

35-021

Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 94975, Rzeszów

85-796

Centrum Onkologii Lukaszczyka /ID# 73393, Bydgoszcz

10-513

Olsztynski Osrodek Onkologi /ID# 71060, Olsztyn

61-485

NZOZ Centrum Medyczne HCP /ID# 68102, Poznan

61-866

Wielkopolskie Centrum Onkologi /ID# 71061, Poznan

020962

S.C. lanuli Med Consult SRL /ID# 106955, Bucharest

022328

lnstitutul Oncologic Trestiore /ID# 96742, Bucharest

08035

Hospital Universitario Vall d'Hebron /ID# 97415, Barcelona

08041

Hospital Santa Creu i Sant Pau /ID# 97418, Barcelona

214 28

Skanes Universitetssjukhus /ID# 96475, Malmo

413 45

Sahlgrenska University Hosp /ID# 97715, Gothenburg

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY