Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes Mellitus on Basal Plus Mealtime Insulin

PHASE3CompletedINTERVENTIONAL
Enrollment

807

Participants

Timeline

Start Date

December 31, 2011

Primary Completion Date

January 31, 2013

Study Completion Date

September 30, 2013

Conditions
Type 2 Diabetes Mellitus
Interventions
DRUG

HOE901-U300 (new formulation of insulin glargine)

HOE901-U300 (new insulin glargine 300 units per milliliter \[U/mL\]) subcutaneous (SC) injection once daily (evening) for 12 months on top of mealtime insulin analogue. Dose titration seeking fasting plasma glucose 4.4-5.6 millimole per liter (mmol/L) (80 - 100 milligram per deciliter \[mg/dL\]). After 6 months participants were proposed to participate to the administration substudy and to receive either HOE901-U300 once daily at intervals of 24 +/- 3 hours (adaptable dosing intervals) or to continue once daily injections of HOE901-U300 every 24 hours (fixed dosing intervals) up to Month 9.

DRUG

Lantus (insulin glargine)

Lantus (HOE901-U100, insulin glargine 100 U/mL) SC injection once daily (evening) for 12 months on top of mealtime insulin analogue. Dose titration seeking fasting plasma glucose 4.4-5.6 mmol/L (80 - 100 mg/dL).

Trial Locations (193)

1083

Investigational Site Number 348015, Budapest

1088

Investigational Site Number 348013, Budapest

1134

Investigational Site Number 348017, Budapest

1139

Investigational Site Number 348009, Budapest

1450

Investigational Site Number 710005, Alberton

1820

Investigational Site Number 710006, Lenasia

2198

Investigational Site Number 710003, Johannesburg

3300

Investigational Site Number 348008, Eger

3980

Investigational Site Number 348011, Sátorlaljaújhely

4043

Investigational Site Number 348005, Debrecen

4400

Investigational Site Number 348007, Nyiregyháza

5700

Investigational Site Number 348018, Gyula

6500

Investigational Site Number 348010, Baja

6722

Investigational Site Number 348003, Szeged

6900

Investigational Site Number 348014, Makó

7130

Investigational Site Number 710004, Somerset West

7500

Investigational Site Number 710001, Paarl

7925

Investigational Site Number 710002, Observatory

8230

Investigational Site Number 348004, Balatonfüred

8900

Investigational Site Number 348001, Zalaegerszeg

9200

Investigational Site Number 348012, Mosonmagyaróvár

9700

Investigational Site Number 348006, Szombathely

11313

Investigational Site Number 233004, Tallinn

11913

Investigational Site Number 233006, Tallinn

12808

Investigational Site Number 203008, Prague

13415

Investigational Site Number 233003, Tallinn

13419

Investigational Site Number 233001, Tallinn

15401

Investigational Site Number 840007, Uniontown

17019

Investigational Site Number 250004, La Rochelle

20852

Investigational Site Number 840034, Rockville

21237

Investigational Site Number 840036, Baltimore

Investigational Site Number 840155, Baltimore

23185

Investigational Site Number 840075, Williamsburg

23235

Investigational Site Number 840104, Richmond

23321

Investigational Site Number 840035, Chesapeake

23502

Investigational Site Number 840074, Norfolk

23507

Investigational Site Number 840112, Norfolk

23510

Investigational Site Number 840041, Norfolk

26601

Investigational Site Number 203006, Beroun

28401

Investigational Site Number 840045, Wilmington

28601

Investigational Site Number 840145, Hickory

28801

Investigational Site Number 840146, Asheville

29651

Investigational Site Number 840079, Greer

30045

Investigational Site Number 840055, Lawrenceville

31000

Investigational Site Number 484007, Chihuahua City

32117

Investigational Site Number 840049, Daytona Beach

32204

Investigational Site Number 840086, Jacksonville

32216

Investigational Site Number 840011, Jacksonville

32258

Investigational Site Number 840009, Jacksonville

33021

Investigational Site Number 840050, Hollywood

34652

Investigational Site Number 840023, New Port Richey

34684

Investigational Site Number 840148, Palm Harbor

34761

Investigational Site Number 840012, Ocoee

37404

Investigational Site Number 840039, Chattanooga

37912

Investigational Site Number 840159, Knoxville

40504

Investigational Site Number 840080, Lexington

42003

Investigational Site Number 840042, Paducah

42060

Investigational Site Number 484004, Pachuca

43213

Investigational Site Number 840106, Columbus

43537

Investigational Site Number 840119, Maumee

44060

Investigational Site Number 840122, Mentor

44670

Investigational Site Number 484006, Guadalajara

45236

Investigational Site Number 840008, Cincinnati

45439

Investigational Site Number 840123, Dayton

46123

Investigational Site Number 840078, Avon

Investigational Site Number 840089, Avon

Investigational Site Number 840097, Avon

Investigational Site Number 840098, Avon

Investigational Site Number 840100, Avon

47591

Investigational Site Number 840127, Vincennes

48034

Investigational Site Number 840022, Southfield

48106

Investigational Site Number 840065, Ann Arbor

48124

Investigational Site Number 840066, Dearborn

48504

Investigational Site Number 840103, Flint

49048

Investigational Site Number 840126, Kalamazoo

50005

Investigational Site Number 203003, Hradec Králové

50314

Investigational Site Number 840116, Des Moines

50410

Investigational Site Number 233005, Tartu

55122

Investigational Site Number 840068, Eagan

55270

Investigational Site Number 276003, Schwabenheim

55318

Investigational Site Number 840143, Chaska

55416

Investigational Site Number 840085, Minneapolis

57701

Investigational Site Number 840048, Rapid City

58103

Investigational Site Number 840067, Fargo

59901

Investigational Site Number 840053, Kalispell

60050

Investigational Site Number 840020, McHenry

62250

Investigational Site Number 484001, Cuernavaca

62704

Investigational Site Number 840019, Springfield

64460

Investigational Site Number 484003, Monterrey

67091

Investigational Site Number 250002, Strasbourg

67211

Investigational Site Number 840003, Wichita

68025

Investigational Site Number 840090, Fremont

68130

Investigational Site Number 840091, Omaha

69115

Investigational Site Number 276006, Heidelberg

69501

Investigational Site Number 203002, Hodonín

70210

Investigational Site Number 246005, Kuopio

71913

Investigational Site Number 840016, Hot Springs

72143

Investigational Site Number 840032, Searcy

72205

Investigational Site Number 840015, Little Rock

Investigational Site Number 840124, Little Rock

75230

Investigational Site Number 840001, Dallas

75246

Investigational Site Number 840047, Dallas

75301

Investigational Site Number 203007, Hranice

76054

Investigational Site Number 840120, Hurst

76901

Investigational Site Number 203009, Holešov

77096

Investigational Site Number 840082, Houston

77900

Investigational Site Number 203010, Olomouc

78731

Investigational Site Number 840021, Austin

Investigational Site Number 840129, Austin

78758

Investigational Site Number 840081, Austin

79401

Investigational Site Number 203004, Krnov

79601

Investigational Site Number 203005, Prostějov

80018

Investigational Site Number 233002, Pärnu

80501

Investigational Site Number 840092, Longmont

80906

Investigational Site Number 840114, Colorado Springs

80910

Investigational Site Number 840136, Colorado Springs

83404

Investigational Site Number 840052, Idaho Falls

83686

Investigational Site Number 840117, Nampa

84020

Investigational Site Number 840010, Draper

84403

Investigational Site Number 840060, Ogden

85028

Investigational Site Number 840071, Phoenix

85224

Investigational Site Number 840156, Chandler

85282

Investigational Site Number 840070, Tempe

85306

Investigational Site Number 840102, Glendale

85351

Investigational Site Number 840121, Sun City

89148

Investigational Site Number 840058, Las Vegas

90100

Investigational Site Number 246002, Oulu

91345

Investigational Site Number 840099, Mission Hills

91436

Investigational Site Number 840133, Encino

91942

Investigational Site Number 840004, La Mesa

92037

Investigational Site Number 840059, La Jolla

92161

Investigational Site Number 840005, San Diego

92262

Investigational Site Number 840107, Palm Springs

92648

Investigational Site Number 840057, Huntington Beach

92780

Investigational Site Number 840013, Tustin

92801

Investigational Site Number 840076, Anaheim

94598

Investigational Site Number 840002, Walnut Creek

94904

Investigational Site Number 840062, Greenbrae

97504

Investigational Site Number 840083, Medford

300133

Investigational Site Number 642007, Timișoara

400006

Investigational Site Number 642002, Cluj-Napoca

410169

Investigational Site Number 642003, Oradea

540142

Investigational Site Number 642009, Târgu Mureş

600114

Investigational Site Number 642001, Bacau

700164

Investigational Site Number 642006, Bucharest

700547

Investigational Site Number 642004, Iași

700613

Investigational Site Number 642008, Iași

08274

Investigational Site Number 840043, Brick

08721

Investigational Site Number 840152, Toms River

97239-3098

Investigational Site Number 840084, Portland

53209-0996

Investigational Site Number 840018, Milwaukee

L0R 1B0

Investigational Site Number 124024, Beamsville

L7M 4Y1

Investigational Site Number 124025, Burlington

T2H 2G4

Investigational Site Number 124023, Calgary

T2N 4L7

Investigational Site Number 124020, Calgary

N7L 1C1

Investigational Site Number 124019, Chatham

V3K 3P4

Investigational Site Number 124018, Coquitlam

L8L 5G8

Investigational Site Number 124021, Hamilton

L8N 3Z5

Investigational Site Number 124014, Hamilton

H7T 2P5

Investigational Site Number 124006, Laval

N6A 4V2

Investigational Site Number 124009, London

L5M 2V8

Investigational Site Number 124008, Mississauga

H2W 1R7

Investigational Site Number 124015, Montreal

H2W 1T8

Investigational Site Number 124004, Montreal

L1H 7K4

Investigational Site Number 124005, Oshawa

G1V 4G5

Investigational Site Number 124026, Québec

T4N 6V7

Investigational Site Number 124002, Red Deer

H4T 1Z9

Investigational Site Number 124017, Saint-Laurent

L4J 8L7

Investigational Site Number 124007, Thornhill

M4G 3E8

Investigational Site Number 124001, Toronto

M5C 2T2

Investigational Site Number 124011, Toronto

V8V 4A1

Investigational Site Number 124010, Victoria

R3E 3P4

Investigational Site Number 124022, Winnipeg

690 02

Investigational Site Number 203001, Břeclav

00260

Investigational Site Number 246001, Helsinki

01587

Investigational Site Number 276002, Riesa

Unknown

Investigational Site Number 348002, Budapest

LV-5201

Investigational Site Number 428006, Jēkabpils

LV-5001

Investigational Site Number 428005, Ogre

LV-1002

Investigational Site Number 428002, Riga

LV-1038

Investigational Site Number 428001, Riga

LV-1050

Investigational Site Number 428004, Riga

LV-2150

Investigational Site Number 428003, Sigulda

7609 PP

Investigational Site Number 528009, Almelo

5631 BM

Investigational Site Number 528004, Eindhoven

9728 NT

Investigational Site Number 528007, Groningen

7909 AA

Investigational Site Number 528005, Hoogeveen

1064NP

Investigational Site Number 528001, Hoorn

8934 AD

Investigational Site Number 528008, Leeuwarden

3563 AZ

Investigational Site Number 528006, Utrecht

5912 BL

Investigational Site Number 528002, Venlo

020475

Investigational Site Number 642005, Bucharest

0167

Investigational Site Number 710008, Pretoria

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Sanofi

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