Hypo-fractionated Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Prostate Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

192

Participants

Timeline

Start Date

January 31, 2012

Primary Completion Date

December 31, 2027

Conditions
Prostate Cancer
Interventions
RADIATION

Radiation

"Consists of:~1. Conformal Proton Radiation Dose: 2.5 Gy (RBE) five days a week in 28 treatments over 5.5-6.5 weeks (total dose: 70 Gy (RBE))~2. High Dose Radiation with IMRT alone: 1.8 Gy five days a week in 45 treatments over 9-10 weeks (total dose: 81 Gy)~3. Intraoperative LDR Brachytherapy and IMRT: 100Gy Pad103 implant and IMRT 1.8 Gy five days a week in 25 treatments over 5-6 weeks (total dose: 45 Gy)"

DRUG

Androgen Suppression Therapy

Androgen suppression will begin 8 - 10 weeks prior to the start of RT for a total of 6 (+/- 2) months. Luteinizing Hormone-Releasing Hormone (LHRH) agonist therapy will consist of analogs approved by the FDA (or by Health Canada for Canadian institutions)

Trial Locations (4)

23666

RECRUITING

Hampton University Proton Therapy Institute, Hampton

60555

RECRUITING

Northwestern Medicine Chicago Proton Center, Warrenville

73142

RECRUITING

Oklahoma Proton Center, Oklahoma City

85259-5499

RECRUITING

Mayo Clinic, Scottsdale

All Listed Sponsors
lead

Proton Collaborative Group

NETWORK