3
Participants
Start Date
January 31, 2012
Primary Completion Date
October 31, 2013
Study Completion Date
October 31, 2014
Sirolimus
Sirolimus will be administered as a 6-mg oral loading dose beginning on day -1, followed by 3 mg per day orally in a single morning dose with a target trough level of 5-12 ng/mL. Trough levels will be measured once a week. Sirolimus will be gradually tapered beginning at day +100, and eliminated by day +180, unless the patient required continued treatment for GVHD or experienced toxicity related to drugs.
Tacrolimus
Tacrolimus will be administered beginning on day -1 at 0.05 mg/kg intravenously by continuous infusion every 24 hours, with a target serum level of 5 to 10 ng/mL. Tacrolimus dosing is converted to oral capsules prior to discharge. Trough levels will be measured once a week. Tacrolimus will be gradually tapered beginning at day +100, and eliminated by day +180, unless the patient required continued treatment for GVHD or experienced toxicity related to drugs.
Soonchunhyang University Bucheon Hospital, Bucheon-si
Collaborators (1)
Asan Medical Center
OTHER
Chonbuk National University Hospital
OTHER
Chonnam National University Hospital
OTHER
Chung-Ang University Hosptial, Chung-Ang University College of Medicine
OTHER
Daegu Catholic University Medical Center
OTHER
Ewha Womans University Mokdong Hospital
OTHER
Gachon University Gil Medical Center
OTHER
Inha University Hospital
OTHER
Inje University
OTHER
Keimyung University Dongsan Medical Center
OTHER
Korea University Anam Hospital
OTHER
Pusan National University Hospital
OTHER
Samsung Medical Center
OTHER
Severance Hospital
OTHER
Seoul St. Mary's Hospital
OTHER
Seoul National University Hospital
OTHER
Soonchunhyang University Hospital
OTHER
The Korean Society of Blood and Marrow Transplantation
OTHER