NCT01478074 - ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia | Biotech Hunter

Timeline

Start Date

November 30, 2011

Primary Completion Date

October 31, 2013

Study Completion Date

November 30, 2013

Conditions

Acute Myeloid Leukemia

Interventions

DRUG

G-CSF

5 mcg/kg daily from day -7 until post-nadir ANC \> 1000

DRUG

Cytarabine

2 g/m2 daily from day -6 through -2

DRUG

Fludarabine

30 mg/m2 daily from day -6 through -2

BIOLOGICAL

Donor Natural Killer (NK) cells

Infused once on day 0. Four cohorts of escalating doses receiving 0, 1, 10, or 20 x 10\^6 cells/Kg

BIOLOGICAL

ALT-801

0.04 mg/kg IV thrice weekly for 8 doses beginning day +2

Trial Locations (1)

MD Anderson Cancer Center, Houston