Phase 1 Dose Escalation Study of ARQ 092 in Adult Subjects With Advanced Solid Tumors and Recurrent Malignant Lymphoma

PHASE1CompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

November 30, 2011

Primary Completion Date

July 6, 2017

Study Completion Date

August 7, 2017

Conditions
Solid TumorMalignant LymphomaTumor
Interventions
DRUG

ARQ 092

Subjects in this study will receive ARQ 092 orally at dose levels specified for their respective dose cohorts. Dosing will begin at 10 mg every other day (QOD) and will escalate until the MTD or RP2D is determined. Cycles will be repeated in four-week (28 day) intervals until progression of disease, unacceptable toxicity, or another discontinuation criterion is met. In the case of toxicity, dose adjustment will be permitted.

Trial Locations (7)

30322

Atlanta

30341

Atlanta

33136

Miami

35294

Birmingham

47905

Lafayette

78229

San Antonio

85258

Scottsdale

All Listed Sponsors
lead

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

INDUSTRY

NCT01473095 - Phase 1 Dose Escalation Study of ARQ 092 in Adult Subjects With Advanced Solid Tumors and Recurrent Malignant Lymphoma | Biotech Hunter | Biotech Hunter