International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

NACompletedINTERVENTIONAL
Enrollment

5,179

Participants

Timeline

Start Date

July 31, 2012

Primary Completion Date

June 30, 2019

Study Completion Date

May 30, 2023

Conditions
Cardiovascular DiseasesCoronary DiseaseCoronary Artery DiseaseHeart DiseasesMyocardial Ischemia
Interventions
PROCEDURE

cardiac catheterization

Narrowed blood vessels can be opened without surgery using stents or can be bypassed with surgery. To determine which is the best approach for you the doctor needs to look at your blood vessels to see where the narrowings are and how much narrowing there is. This is done by a procedure known as a cardiac catheterization.

PROCEDURE

coronary artery bypass graft surgery

"Artery narrowing is bypassed during surgery with a healthy artery or vein from another part of the body. This is known as coronary artery bypass grafting, or CABG (said, cabbage). The surgery creates new routes around narrowed and blocked heart arteries. This allows more blood flow to the heart."

PROCEDURE

percutaneous coronary intervention

Percutaneous coronary intervention may be done as part of the cardiac catheterization procedure. With this procedure a small, hollow, mesh tube (stent) is inserted into the narrowed part of the artery. The stent pushes the plaque against the artery wall, and opens the vessel to allow better blood flow.

BEHAVIORAL

Lifestyle

diet, physical activity, smoking cessation

DRUG

Medication

antiplatelet, statin, other lipid lowering, antihypertensive, and anti-ischemic medical therapies

Trial Locations (320)

18

Instituto Neuro Cardiovascular De Las Americas, Miraflores

1000

University Clinic of Cardiology, Skopje

1090

Medical University of Vienna, Department of Cardiology, Vienna

1097

Eszszk- Szent Istvan Hospital, Budapest

1117

Military Hospital, Budapest, Budapest

1122

Heart and Vascular Center, Semmelweis University, Budapest

1142

Auckland City Hospital, Auckland

2305

John Hunter Hospital, New Lambton Heights

3000

University Hospital Leuven, Leuven

3100

Instituto Mexicano del Seguro Social, Benito Juárez

3240

Waikato Hospital, Hamilton

5000

Clinica Del Prado, Córdoba

Clinica Romagosa and Clinica De La Familia, Córdoba

Clínica Privada Vélez Sarsfield, Córdoba

5009

Instituto Medico DAMIC, Córdoba

5011

The Queen Elizabeth Hospital, Woodville South

5042

Flinders Medical Centre, Adelaide

6000

Royal Perth Hospital, Perth

6720

University of Szeged, Szeged

6900

Cardiocentro, Lugano

7945

Groote Schuur Hospital / University of Cape Town, Cape Town

8000

Hospital Italiano Regional del Sur Bahia Blanca, Bahía Blanca

8020

LKH Graz West Austria, Graz

10010

VA New York Harbor Health Care System, New York

10016

Beth Israel Medical Center, New York

NYU Langone Medical Center-Bellevue Hospital, New York

10022

NYU New York Medical Associates, New York

10025

Mount Sinai Saint Luke's Hospital, New York

10029

Icahn School of Medicine at Mount Sinai, New York

10032

Columbia University Medical Center, New York

10400

Ramathibodi Hospital, Bangkok

10449

Mackay Memorial Hospital, Taipei

10451

NYU-HHC Lincoln Medical and Mental Health Center, The Bronx

10461

Jacobi Medical Center, The Bronx

10567

NYP Medical Medical Group Hudson Valley Cardiology, Cortlandt Manor

11000

Clinical Center of Serbia, Belgrade

Faculty of Medicine, University of Belgrade; Cardiology Clinic, Clinical Center of Serbia, Belgrade

University Clinical Hospital Zvezdara, Belgrade

University Hospital Center Bezanijska Kosa, Belgrade

Clinical Center Kragujevac, Kragujevac

11030

Northwell Health - Manhasset, Manhasset

11100

Ospedale Regionale Umberto Parini, Aosta

11203

NYU-HHC Kings County Hospital Center, Brooklyn

11215

New York -Presbyterian/Brooklyn Methodist Hospital, Brooklyn

11229

NYU-HHC Woodhull Hospital, Brooklyn

11235

Coney Island Hospital, Brooklyn

11355

New York University - Langone Cardiovascular Associates, Flushing

11426

King AbdulAziz Cardiac Center, Riyadh

11501

NYU Winthrop, Mineola

11562

Cairo University, Cairo

12100

Azienda Ospedaliera S. Croce e Carle, Cuneo

12208

Albany Medical Center Hospital, Albany

Samuel Stratton VA Medical Center of Albany NY, Albany

12211

Capital Cardiology Associates, Albany

12309

Cardiology Associates of Schenectady P.C., Schenectady

12401

Mid Valley Cardiology, Kingston

14080

"Instituto Nacional de Cardiología Ignacio Chávez", Mexico City

14642

University of Rochester, Rochester

15008

Complexo Hospitalario Universitario A Coruña (CHUAC) Sergas, Department of Cardiology. INIBIC A Coruña. CIBER-CV. Universidad de A Coruña, Spain, A Coruña

15706

Hospital Clinico Universitario de Santiago, Santiago de Compostela

15905

Conemaugh Valley Memorial Hospital, Johnstown

17011

Holy Spirit Hospital Cardiovascular Institute, Camp Hill

18000

Clinic for Cardiovascular Diseases, Clinical Center Nis, Niš

18018

Saint Luke's Hospital and Health Network, Bethlehem

18901

Doylestown Health Cardiology, Doylestown

20089

Humanitas Research Hospital, Rozzano (MI), Rozzano

20814

NIH Heart Center at Suburban Hospital, Bethesda

20889

Walter Reed National Military Medical Center, Bethesda

20900

Policlinico di Monza, Monza MB, Monza

21100

Ospedale di Circolo e Fondazione Macchi, Varese

21201

University of Maryland Medical Center, Baltimore

21204

Institute of Cardiovascular Diseases Vojvodina, Sremska Kamenica, Serbia and Faculty of Medicine, University of Novi Sad, Kamenitz

22601

Winchester Cardiology and Vascular Medicine, PC, Winchester

23320

Cardiovascular Associates, Ltd., Chesapeake

24501

Stroobants Cardiovascular Center, Lynchburg

27710

Duke University Medical Center, Durham

28007

Hospital General Universitario Gregorio Maranon, Madrid

28018

C.H. Louis Pasteur, Châtres

28046

Hospital La Paz. IdiPaz, Madrid

28803

Asheville Cardiology Associates, Asheville

30033

Atlanta VA Medical Center, Decatur

30120

HUVA, Hospital Clínico Universitario Virgen De La Arrixaca, Murcia

30322

Emory University, Atlanta

31096

Rambam Medical Center, Haifa

32114

Daytona Heart Group, Daytona Beach

32224

Mayo Clinic Florida, Jacksonville

32608

Malcom Randall VAMC, Gainesville

33028

Azienda Servizi Sanitaria n.3 Alto Friuli-Collinare-Medio Friuli, Tolmezzo

33606

University of South Florida, Tampa

34239

Cardiovascular Center of Sarasota, Sarasota

Sarasota Memorial Hospital, Sarasota

35100

University of Padua- Cardiology Clinic, Padua

35294

UAB Vascular Biology and Hypertension Program, Birmingham

37232

Vanderbilt University Medical Center, Nashville

38700

Grenoble University Hospital, Grenoble

40292

University of Louisville, Louisville

40536

University of Kentucky, Lexington

42503

Lexington VA Medical Center, Lexington

43215

Ohio Health Grant Medical Center, Columbus

44106

Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland

45220

Cincinnati VA Medical Center, Cincinnati

46026

Hospital Universitario y Politecnico La Fe, Valencia

46202

Indiana University/Krannert Institute of Cardiology, Indianapolis

47100

"Ospedale G.B. Morgagni - L. Pierantoni Forli (AUSL della Romagna)", Forlì

48075

Providence - Providence Park Hospital, Southfield

48197

Michigan Heart, PC, Ypsilanti

48202

Henry Ford Health System, Detroit

49503

Spectrum Health, Grand Rapids

49933

Centre Hospitalier Universitaire d'Angers, Angers

50009

Hospital Universitario Miguel Servet, Zaragoza

50200

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai

50400

Institut Jantung Negara, Kuala Lumpur

52242

University of Iowa Hospitals and Clinics, Iowa City

52803

Midwest Cardiovascular Research Foundation, Davenport

53105

Universitatsklinikum Bonn, Bonn

54100

UO Cardiologia Ospedale SS Cosma e Damiano, Pescia

54601

Gundersen Lutheran Medical Center, La Crosse

55102

HealthEast Saint Joseph's Hospital, Saint Paul

55417

Minneapolis VAMC, Minneapolis

55455

University of Minnesota, Minneapolis

55905

Mayo Clinic, Rochester

58122

Sanford Health, Fargo

60020

Cardiology and CCU - Ospedali Riuniti Ancona, Ancona

60153

Loyola University Medical Center, Maywood

62208

Advanced Heart Care Group, Fairview Heights

64111

Saint Luke's Hospital, Kansas City

64128

Kansas City VA Medical Center, Kansas City

67891

Assuta Medical Centers, Tel Aviv

70376

Robert-Bosch-Krankenhaus, Stuttgart

70601

Cardiovascular Specialists of Southwest Louisiana, Lake Charles

71013

"IRCCS Casa Sollievo della Sofferenza", San Giovanni Rotondo

74133

Oklahoma Heart Institute, Tulsa

75018

Bichat Hospital, Paris

75024

Baylor Research Institute at Legacy Heart Center, Plano

75093

The Heart Hospital Baylor, Plano

75216

V.A. North Texas Health Care System, Dallas

76301

Wichita Falls Heart Clinic, Wichita Falls

77030

Baylor College of Medicine, Houston

Baylor St. Luke's Medical Center, Houston

77339

Houston Heart & Vascular Associates, Houston

77478

Medicus Alliance Clinical Research Org., Inc., Sugar Land

78229

Audie Murphy V.A., San Antonio

80120

South Denver Cardiology Associates, P.C., Littleton

80121

Clinica Mediterranea, Naples

80131

"AORN Dei Colli V. Monaldi UOC Cardiologia Università della Campania L.Vanvitelli", Napoli

80538

Medical Center of the Rockies, Loveland

84148

Salt Lake City VA Medical Center, Salt Lake City

85364

Yuma Regional Medical Center, Yuma

90095

Ronald Reagan UCLA Medical Center, Los Angeles

90211

Cedars Sinai Medical Center, Beverly Hills

90505

Torrance Memorial Medical Center, Torrance

91100

Centre Hospitalier Sud Francilien, Corbeil-Essonnes

92100

Ambroise Pare Hospital, Boulogne-Billancourt

92141

Antoine-Beclere Hospital, Clamart

92704

Coastal Heart Medical Group, Santa Ana

92868

University of California Irvine Medical Center, Orange

93721

UCSF - Fresno Community Regional Medical Center, Fresno

94087

Palo Alto Medical Foundation Research Institute, Palo Alto

94305

Stanford University School of Medicine, Stanford

94538

Kaiser Permanente San Jose, San Jose

94550

VA Palo Alto HealthCare System, Palo Alto

97201

Oregon Health & Science University, Portland

97225

Providence Heart and Vascular Institute, Portland

98004

University of Washington Medical Center, Bellevue

100020

Beijing Chao-yang Hospital, Capital Medical University, Beijing

100029

Beijing Anzhen Hospital, Beijing

100037

Chinese Academy of Medical Sciences, Fuwai Hospital, Beijing

100730

Peking Union Medical College Hospital, Beijing

102401

Liangxiang Hospital, Beijing Fangshan District, Beijing

110001

Dr Ram Manohar Lohia Hospital, New Delhi

110025

Fortis Escort Heart Institute, New Delhi

110029

All India Institute of Medical Sciences, New Delhi

110062

Batra Hospital and Medical Research Centre (BHMRC), New Delhi

110070

Fortis Healthcare Fl.t Lt. Rajan Dhall Hospital, New Delhi

116001

Affiliated Zhongshan Hospital of Dalian University, Dalian

119228

National University Heart Center Singapore, Singapore

121552

National Medical Research Center for Cardiovascuar Surgery, Moscow

141001

Hero DMC Heart Institute, Dayanand Medical College and Hospital, Ludhiana

169609

National Heart Centre Singapore, Singapore

197341

Federal Almazov North-West Medical Research Centre, Saint Petersburg

199106

North-Western State Medical University, Saint Petersburg

226003

King George's Medical University, Department of Cardiology, Lucknow

266071

Qingdao Fuwai Hospital, Qingdao

272000

Affiliated Hospital of Jining Medical University, Jining

300457

TEDA International Cardiovascular Hospital, Tianjing

308433

Tan Tock Seng Hospital, Singapore

310009

The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

373203

Saint Thomas Hospital, Nashville

411001

Ruby Hall Clinic,Grant Medical Foundation, Pune

411011

KEM Hospital Pune, Pune

430030

Tongji Medical College, Wuhan

450014

The Second Affiliated Hospital of Zhengzhou University, Zhengzhou

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

500001

CARE Nampally, Hyderabad

500020

Gurunanak CARE Hospital, Hyderabad

500034

CARE Hospital, Hyderabad

510100

Guangdong General Hospital, Guangzhou

560069

Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore

600081

Apollo Research and Innovation, Chennai

Apollo Research & Innovations, Hyderabad

605006

Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry

630055

E.Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, Novosibirsk

673008

Government Medical College, Calicut

682311

MOSC Medical College Hospital, Kolenchery, Kolenchery

695011

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum

710000

Shanxi Provincial People's Hospital, Xian

830054

First Affiliated Hospital of Xinjiang Medical University, Ürümqi

1418100

Hospital TotalCor, São Paulo

99010080

Hospital Sao Vicente de Paulo, Fundo

06111

VA Connecticut Healthcare System, West Haven

02115

Brigham & Women's Hospital, Harvard Medical School, Boston

02118

Boston Medical Center, Boston

02132

VA Boston Healthcare System, West Roxbury

01608

Saint Vincent Hospital at Worcester Medical Center, Worcester

01876

Covenant Medical Center, Inc., Saginaw

07631

Englewood Hospital and Medical Center, Englewood

08240

AtlantiCare Regional Medical Center, Pomona

07663

Hackensack University Medical Center, Saddle Brook

02906

Miriam Hospital, Providence

02886

Kent Hospital, Warwick

05009

VAMC-White River Junction, White River Junction

C1093AAS

Fundacion Favaloro, Ciudad Autonoma de Buenos Aires

A-1160

Wilhelminen Hospital Vienna, Vienna

41810-010

Fundacao Bahiana de Cardilogia, Salvador

30110-921

Hospital Lifecenter, Belo Horizonte

37701-045

Hospital Maternidade e Pronto Socorro Santa Lucia, Poços de Caldas

80045-170

Quanta Diagnostico & Terapia, Curitiba

80320-320

Hospital Cardiologico Costantini, Curitiba

22280-020

Hospital Pró-Cardíaco, Botafogo

90035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre

90610-000

Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sol, Porto Alegre

90620-001

Instituto de Cardiologia de Porto Alegre, Porto Alegre

04012-909

Instituto Dante Pazzanese de Cardiologia, Ibirapuera

14048-900

Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto

BA, 41820-011

Hospital da Bahia, Salvador

04025-011

Unifesp - Hospital Sao Paulo, São Paulo

05403-000

Heart Institute (InCor) University of São Paulo, São Paulo

13059-740

Hospital Celso Pierro, São Paulo

T2N 2T9

University of Calgary, Calgary

T6G 2B7

University of Alberta, Edmonton

V5Z 1M9

Vancouver General Hospital, Vancouver

L3M 1P3

West Lincoln Memorial Hospital, Grimsby

L8L 2X2

Hamilton General Hospital, Hamilton

N6A 5A5

London Health Sciences Centre, London

L4W 0C2

Dixie Medical Group, Mississauga

L1J 2K1

Dr. James Cha, Oshawa

M1E 5E9

Scarborough Cardiology Research, Scarborough Village

L2S0A9

Saint Catharines General Hospital, St. Catharines

M5B 1W8

St. Michael's Hospital, Toronto

M5G 1N8

Women's College Hospital, Toronto

M5G 2C4

University Health Network, Toronto

L4H0P6

Northwest GTA Cardiovascular and Heart Rhythm Program, Vaughan

H1T 1C8

Montreal Heart Institute, Montreal

H4J 1C5

Centre Intégré Universitaire de Santé et de Services Sociaux du Montréal, Montreal

J6V 2H2

CISSSL - Hopital Pierre-Le Gardeur, Terrebonne

G8Z 3R9

Centre Hospitalier de Regional Trois-Rivieres, Trois-Rivières

K1Y 4W7

University of Ottawa Heart Institute, Ottawa

063000

Tangshan Gongren Hospital, Tangshan

Unknown

Wuhan Asia Heart Hospital, Wuhan

Wuhan Union Hospital, Tongji Medical College, Huazhong Science and Tech University, Wuhan

030024

Shanxi Cardiovascular Hospital, Taiyuan

D-01099

Praxisklinik Herz Und Gefaesse, Dresden

07747

University Hospital Jena, Jena

H-1096

George Gottsegen National Institute of Cardiology, Budapest

565-8565

National Cerebral and Cardiovascular Center, Suita-shi

350-0495

Saitama Medical University, Hidaka

160-8582

Keio University Hospital, Shinjuku-Ku

LT-08661

Vilnius University Hospital Santariskes Clinic, Vilnius

1091 AC

Cardio Research Hartcentrum OLVG, Amsterdam

6500 HB

Radboudumc, Nijmegen

8025 AB

Isala Klinieken, Zwolle

54-090

T.Marciniak Hospital, Wroclaw

31-200

Department of Coronary Disease, John Paul II Hospital, Jagiellonian University Medical College, Krakow

02-005

Department of Internal Medicine and Cardiology, Infant Jesus Teaching Hospital, Medical University of Warsaw, Warsaw

04-628

Coronary and Structural Heart Diseases Department, Institute of Cardiology, Warsaw

Department of Interventional Cardiology & Angiology, Institute of Cardiology, Warsaw

Institute of Cardiology, Warsaw, Warsaw

PL-02-097

Medical University of Warsaw, Warsaw

15-276

University Hospital in Bialystok, Bialystok

41-800

Medical University of Silesia, School of Medicine with the Division of Dentistry, Department of Cardiology, Congenital Heart Diseases and Electrotherapy, Silesian Center for Heart Diseases, Zabrze

61-848

Szpital Kliniczny Przemienienia Pańskiego, Poznan

50-981

Military Hospital / Medical University, Wroclaw

91-425

Cardiology Clinic, Medical University in Lodz, Lodz

1150-291

Hospital de Santa Marta, Lisbon

1649-028

Santa Maria University Hospital, Cardiology Department, CHLN, Lisbon

4434-502

Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia

021967

Emergency County Hospital Baia Mare, Baia Mare

022328

Emergency Institute of Cardiovascular Diseases ''Prof. Dr. C. C. Iliescu'', Bucharest

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

08907

Hospital De Bellvitge, Barcelona

S-18288

Karolinska Institutet at Danderyd Hospital, Stockholm

SE-751 85

Uppsala University, Uppsala

BT12 6BA

Belfast Trust, Belfast

MK42 9DJ

Bedford Hospital NHS Trust, Bedford

LU4 0DZ

Luton and Dunstable University Hospital NHS FT, Luton

CB23 3RE

Papworth Hospital, Cambridge

PE3 9GZ

Peterborough City Hospital, Peterborough

TS4 3BW

The James Cook University Hospital, Middlesbrough, Middlesbrough

BH7 7DW

Royal Bournemouth Hospital, Bournemouth

DT1 2JY

Dorset County Hospital, Dorchester

HU16 5JQ

The University of Hull/Castle Hill Hospital, Cottingham

CM1 7ET

Broomfield Hospital, Chelmsford

SS0 0RY

Southend University Hospital, Westcliff-on-Sea

RG24 9NA

Hampshire Hospitals NHS Foundation Trust, Basingstoke

FY3 8NR

Blackpool Teaching Hospitals, Blackpool

OL1 2JH

The Pennine Acute Hospitals NHS Trust, Oldham

HA1 3UJ

Northwick Park Hospital Harrow/ Royal Brompton Hospital London, Harrow

BT16 1RH

South Eastern Health and Social Care, Belfast

BT63 5QQ

Cardiovascular Research Unit, Craigavon Area Hospital, Craigavon

NG5 1PB

Nottingham University Hospitals, Nottingham

EH4 2XU

Royal Infirmary of Edinburgh, Edinburgh

G81 4DY

University of Glasgow, Clydebank

DY1 2HQ

Russells Hall Hospital, Dudley

BD9 6RJ

Bradford Royal Infirmary, Bradford

WF1 4DG

Pinderfields Hospital, Wakefield

EC1A 7BE

University College London Hospitals NHS Foundation Trust/Barts Health NHS Trust, London

NW3 2QG

Royal Free London NHS Foundation Trust, London

SE13 6LH

King's College NHS Foundation Hospital, London

W12OHS

Imperial College Healthcare NHS Trust, London

M13 9WL

Central Manchester University Hospital, Manchester

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

New York University

OTHER

collaborator

Stanford University

OTHER

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Albany Stratton VA Medical Center

FED

collaborator

Cedars-Sinai Medical Center

OTHER

collaborator

Columbia University

OTHER

collaborator

Duke University

OTHER

collaborator

East Carolina University

OTHER

collaborator

Emory University

OTHER

collaborator

Harvard University

OTHER

collaborator

Massachusetts General Hospital

OTHER

collaborator

Montreal Heart Institute

OTHER

collaborator

University of British Columbia

OTHER

collaborator

University of Missouri, Kansas City

OTHER

collaborator

Vanderbilt University

OTHER

lead

NYU Langone Health

OTHER

NCT01471522 - International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) | Biotech Hunter | Biotech Hunter