PF-04523655 Dose Escalation Study, and Evaluation of PF-04523655 With/Without Ranibizumab in Diabetic Macular Edema (DME)

PHASE2CompletedINTERVENTIONAL
Enrollment

258

Participants

Timeline

Start Date

February 29, 2012

Primary Completion Date

November 30, 2013

Study Completion Date

November 30, 2013

Conditions
Choroidal NeovascularizationDiabetic RetinopathyDiabetic Macular Edema
Interventions
DRUG

PF-04523655 (Stratum I)

PF-04523655 (a small interfering RNA) - a single IVT injection

DRUG

ranibizumab

6 monthly IVT injections of ranibizumab (Stratum II)

DRUG

PF-04523655 (Stratum II)

6 monthly IVT injections of PF-04523655 (a small interfering RNA)

Trial Locations (51)

1020

Brugmann Ziekenhuis, Laken

9000

University Hospital Ghent, Ghent

23235

Retinal Institute of Virginia, Richmond

28210

Southeast Clinical Research Associates, LLC, Charlotte

30909

Southeast Retina Center, Augusta

31048

Bnai Zion Medical Center, Haifa

33143

MedEye Associates, Miami

33880

Center for Retina and Macular Disease, Winter Haven

37203

Tennessee Retina, PC, Nashville

41902

Szpital Specjalistyczny Nr 1 w Bytomiu, Bytom

44281

Meir Medical Center, Kfar Saba

46290

Thomas A. Cuilla, MD, PC at Midwest Eye Institute, Indianapolis

48145

Augenklinik am St. Franziskus-Hospital Muenster, Münster

48683

Augenärzte Gemeinschaftspraxis Ahaus-Gronau-Lingen-Münster-Bad Bentheim, Ahaus

50005

Fakultní nemocnice Hradec Kralove, Kralove

52621

The Chaim Sheba Medical Center, Tel Litwinsky

57701

Black Hills Regioinal Eye Institute, Rapid City

62500

Fakultni nemocnice Brno, Brno

64297

Augenklinik Klinikum Darmstadt, Darmstadt

67063

Klinikum der Stadt Ludwigshafen, Ludwigshafen

70852

Fakultní nemocnice Ostrava, Ostrava

76001

GEMINI oční centrum, a.s, Zlín

77030

Retinal Consultants of Houston, Houston

78204

Retinal Consultants of San Antonio, San Antonio

78503

Valley Retina Institute, McAllen

78705

Retina Research Center, Austin

80809

Profesorskie Centrum Okulistyki, Hipermarket Tesco, Gdansk

81675

Klinik und Poliklinik für Augenheilkunde Klinikum rechts der Isar, München

84101

Soroka University Medical Center, Beersheba

85014

Retina Consultants of Arizona, Phoenix

85631

Oftalmika, Bydgoszcz

90211

Retina-Vitreous Associates, Beverly Hills

91007

Retina Institute of California, Arcadia

92705

Orange County Reina Medical Group, Santa Ana

95008

Retina Diagnostic Center, Campbell

95819

Retinal Consultants Medical Group, Inc., Sacramento

03801

Eyesight Ophthalmic Services, PA, Portsmouth

08755

Retina Vitreous Center, Toms River

Unknown

Hadassah Ein Kerem Medical Center, Jerusalem

Rabin Medical Center, Petah Tikva

Kaplan Medical Center, Rehovot

Tel Aviv Sourasky Medical Center, Tel Aviv

Assaf Harofe Medical Center, Ẕerifin

51-646

Spectrum OOK, Wroclaw

SO16 6YD

Southamptom Eye Unit, Southampton Hospital, Shirley

GU16 7UJ

Frimley Park Hospital NHS Foundation Trust, Frimley

BT12 6BA

Eye and Ear Clinicl, The Royal Victoria Hospital, Belfast

BS1 2LX

Bristol Eye Hospital, Bristol

LS9 7TF

St. James University Hospital, Leeds

EC1V 2PD

Moorfields Eye Hospital, London

S10 2JF

Royal Hallamshire Hospital, Eye Department, Sheffield

Sponsors
All Listed Sponsors
lead

Quark Pharmaceuticals

INDUSTRY