Rituximab+mVPDL for CD20(+) Adult Acute Lymphoblastic Leukemia

"1. Induction:~ * Dauno 90 mg/m2/d by civ (d1-3)~ * Vinc 2 mg iv (d1, 8)~ * Pred 60 mg/m2/d po (d1-14)~ * for Ph(-): L-asp 4,000 units/m2/day im/sc (d17-28) for Ph(+): Imatinib 600mg/d po qd (d8-continue till the end of maintenance or just before alloHCT)~ * Rituximab 375mg/m2/d (d8)~2. Consolidation A (cycle1)~ * D 45 mg/m2/day by continuous iv (d1, 2)~ * V 2 mg iv (d1, 8)~ * P 60 mg/m2/day po (d1-14)~ * for Ph(-): L-asp (d1-14) for Ph(+): Imatinib~ * Rituximab 375mg/m2/d (d8)~3. Consolidation B (cycles2\&4)~ * Cyt 2,000 mg/m2/d iv over 2 hr (d1-4)~ * Eto 150 mg/m2/d iv over 3 hr (d1-4)~ * Rituximab 375mg/m2/d d8~4. Consolidation C (cycles 3\&5)~ * Methotrexate 220 mg/m2 iv bolus, then 60mg/m2/h for 36 hr (d1-2, 15-16)~ * Leucovorin 50 mg/m2 iv every 6hr for 3 doses,~ * Rituximab 375mg/m2/d (d8\&22)~5. Maintenance (for 2 years)~ \- for Ph(-): 6- Mercaptopurine 60 mg/m2 po qd Methotrexate 20 mg/m2 po qw for Ph(+): imatinib 600mg/d po qd~6. Consider alloHCT"