Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

November 30, 2008

Primary Completion Date

June 30, 2011

Study Completion Date

June 30, 2011

Conditions
Cardiovascular DiseaseAgingEndothelial DysfunctionPhysical Activity
Interventions
DRUG

Alt-711

Alt-711, also known as Alagebrium, an AGE-crosslink breaker, will be given twice daily 100mg

BEHAVIORAL

Physical exercise training

Exercise training will be given three times a week for 45 minutes per training session. The heart rate reserve will be slowly increased from 70% to 85%.

Trial Locations (1)

6525EZ

Radboud University Nijmegen Medical Centre, Nijmegen

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Dutch Heart Foundation

OTHER

collaborator

Synvista Therapeutics, Inc

INDUSTRY

lead

Radboud University Medical Center

OTHER