91
Participants
Start Date
September 30, 2011
Primary Completion Date
March 19, 2020
Study Completion Date
May 20, 2022
Rituximab
One 28-day cycle = 500 mg/m\^2 intravenously on day 1 and day 5.
Cytarabine
One 28-day cycle = 3 g/m\^2 intravenously on day 1 and day 2.
Methotrexate
One 28-day cycle = 3.5 g/m\^2 intravenously (standard hydration/leucovorin support) on day 2.
Procarbazine
One 28-day cycle = 100 mg/m\^2 orally on days 2-8.
Vincristine
One 28-day cycle = 1.4 mg/m\^2 intravenously, dose capped at 2.4mg, on day 2 and day 16.
low-dose whole-brain radiation therapy
Total dose of 2340 cGy administered as 13 daily fractions of 180 cGy over 3 weeks. Participants with progressive disease on magnetic resonance imaging (MRI) do not receive WBRT.
Columbia University Medical Center, New York
Memorial Sloan-Kettering Cancer Center, New York
Memorial Sloan Kettering Cancer Center Commack, Commack
University of Rochester, Rochester
Geisinger Medical Center, Danville
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre
American College of Radiology Imaging Network, Philadelphia
Thomas Jefferson University Hospital, Philadelphia
University of Maryland/Greenebaum Cancer Center, Baltimore
Moffitt Cancer Center, Tampa
University of Alabama at Birmingham Cancer Center, Birmingham
The Kirklin Clinic at Acton Road, Birmingham
Case Western Reserve University, Cleveland
Cleveland Clinic Foundation, Cleveland
University Pointe, West Chester
University of Cincinnati, Cincinnati
West Michigan Cancer Center, Kalamazoo
Community Memorial Hospital, Menomonee Falls
Waukesha Memorial Hospital, Waukesha
Froedtert and the Medical College of Wisconsin, Milwaukee
Loyola University Medical Center, Maywood
Cadence Cancer Center in Warrenville, Warrenville
Northwestern University, Chicago
Rush University Medical Center, Chicago
Tel Aviv Sourasky Medical Center, Tel Aviv
M D Anderson Cancer Center CCOP Research Base, Houston
M D Anderson Cancer Center, Houston
Penrose-Saint Francis Healthcare, Colorado Springs
Saint Alphonsus Cancer Care Center-Boise, Boise
Saint Joseph's Hospital and Medical Center, Phoenix
Arizona Oncology-Deer Valley Center, Phoenix
Arizona Oncology Services Foundation, Scottsdale
Nevada Cancer Research Foundation CCOP, Las Vegas
Fresno Cancer Center, Fresno
Kaiser Permanente Cancer Treatment Center, South San Francisco
Rohnert Park Cancer Center, Rohnert Park
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova
The Permanente Medical Group-Roseville Radiation Oncology, Roseville
South Sacramento Cancer Center, Sacramento
Maine Medical Center-Bramhall Campus, Portland
Maine Medical Center- Scarborough Campus, Scarborough
Saint Joseph Mercy Hospital, Ann Arbor
Dartmouth Hitchcock Medical Center, Lebanon
Memorial Sloan Kettering Cancer Center at Basking Ridge, Basking Ridge
Collaborators (1)
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK