Veliparib With or Without Radiation Therapy, Carboplatin, and Paclitaxel in Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

53

Participants

Timeline

Start Date

June 20, 2011

Primary Completion Date

May 26, 2019

Study Completion Date

December 31, 2025

Conditions
Lung AdenocarcinomaLung Adenocarcinoma, Mixed SubtypeLung Large Cell CarcinomaLung Squamous Cell CarcinomaMinimally Invasive Lung AdenocarcinomaStage III Lung Non-Small Cell Cancer AJCC v7Stage IIIA Lung Non-Small Cell Cancer AJCC v7Stage IIIB Lung Non-Small Cell Cancer AJCC v7
Interventions
RADIATION

3-Dimensional Conformal Radiation Therapy

Undergo 3D-conformal RT

DRUG

Carboplatin

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Paclitaxel

Given IV

OTHER

Placebo Administration

Given PO

DRUG

Veliparib

Given PO

Trial Locations (234)

19605

Penn State Health Saint Joseph Medical Center, Reading

28374

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst

28501

ECU Health Oncology Kinston, Kinston

28791

Margaret R Pardee Memorial Hospital, Hendersonville

38017

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville

38120

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38671

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

44708

Cleveland Clinic Mercy Hospital, Canton

45005

Dayton Physicians LLC-Atrium, Franklin

45042

Dayton Physicians LLC-Signal Point, Middletown

45236

Oncology Hematology Care Inc-Kenwood, Cincinnati

45331

Dayton Physicians LLC-Wayne, Greenville

Wayne Hospital, Greenville

45365

Dayton Physicians LLC-Wilson, Sidney

45373

Dayton Physicians LLC - Troy, Troy

Upper Valley Medical Center, Troy

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

Greater Dayton Cancer Center, Kettering

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Dayton Physicians LLC-Miami Valley South, Centerville

Miami Valley Hospital South, Centerville

45504

Springfield Regional Cancer Center, Springfield

Springfield Regional Medical Center, Springfield

45840

Armes Family Cancer Center, Findlay

Blanchard Valley Hospital, Findlay

Orion Cancer Care, Findlay

46845

Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne

47374

Reid Health, Richmond

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

49007

West Michigan Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

Trinity Health Muskegon Hospital, Muskegon

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50010

McFarland Clinic - Ames, Ames

51101

Siouxland Regional Cancer Center, Sioux City

56601

Sanford Joe Lueken Cancer Center, Bemidji

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59802

Saint Patrick Hospital - Community Hospital, Missoula

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60153

Loyola University Medical Center, Maywood

60504

Rush-Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

60611

Northwestern University, Chicago

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

OSF Saint Joseph Medical Center, Bloomington

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62226

Southwest Illinois Health Services LLP, Swansea

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

62702

Central Illinois Hematology Oncology Center, Springfield

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

62864

SSM Health Good Samaritan, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin

63080

Missouri Baptist Sullivan Hospital, Sullivan

63090

Mercy Hospital Washington, Washington

63109

Mercy Infusion Center - Chippewa, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63628

Parkland Health Center-Bonne Terre, Bonne Terre

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Mercy Cancer Center - Cape Girardeau, Cape Girardeau

Saint Francis Medical Center, Cape Girardeau

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64108

University Health Truman Medical Center, Kansas City

64128

Kansas City Veterans Affairs Medical Center, Kansas City

64131

The University of Kansas Cancer Center-South, Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

65401

Phelps Health Delbert Day Cancer Institute, Rolla

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66061

The University of Kansas Cancer Center - Olathe, Olathe

66112

University of Kansas Cancer Center-West, Kansas City

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66502

Cancer Center of Kansas-Manhattan, Manhattan

66606

University of Kansas Health System Saint Francis Campus, Topeka

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

66762

Mercy Hospital Pittsburg, Pittsburg

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

Wesley Medical Center, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

Salina Regional Health Center, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67530

Central Care Cancer Center - Great Bend, Great Bend

67601

HaysMed, Hays

67801

Cancer Center of Kansas - Dodge City, Dodge City

67846

Saint Catherine Hospital, Garden City

67905

Cancer Center of Kansas-Liberal, Liberal

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

M D Anderson Cancer Center, Houston

78229

Audie L Murphy VA Hospital, San Antonio

Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio

University Hospital, San Antonio

University of Texas Health Science Center at San Antonio, San Antonio

80045

UCHealth University of Colorado Hospital, Aurora

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

90211

Tower Cancer Research Foundation, Beverly Hills

91010

City of Hope Comprehensive Cancer Center, Duarte

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92882

City of Hope Corona, Corona

95340

Mercy Cancer Center, Merced

95817

University of California Davis Comprehensive Cancer Center, Sacramento

96701

Pali Momi Medical Center, ‘Aiea

Queen's Cancer Center - Pearlridge, ‘Aiea

The Cancer Center of Hawaii-Pali Momi, ‘Aiea

96766

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Hawaii Cancer Care Inc-Liliha, Honolulu

Queen's Cancer Center - Kuakini, Honolulu

The Cancer Center of Hawaii-Liliha, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97045

Providence Willamette Falls Medical Center, Oregon City

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98112

Kaiser Permanente Washington, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

99204

MultiCare Deaconess Cancer and Blood Specialty Center - Downtown, Spokane

99216

MultiCare Deaconess Cancer and Blood Specialty Center - Valley, Spokane Valley

99218

MultiCare Deaconess Cancer and Blood Specialty Center - North, Spokane

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

06520

Yale University, New Haven

01805

Lahey Hospital and Medical Center, Burlington

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT01386385 - Veliparib With or Without Radiation Therapy, Carboplatin, and Paclitaxel in Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery | Biotech Hunter | Biotech Hunter