514
Participants
Start Date
December 31, 2006
Primary Completion Date
May 29, 2019
Study Completion Date
December 2, 2022
Diseased periodontal treatment
"Treatment includes scaling and root planing with systemic antibiotics, Amoxicillin 500 mg and Metronidazole 250 mg tid 7 days. At certain intervals after the scaling and root planing, your gums will be reevaluated. You will receive further surgical gum therapy only if your gums haven't shown improvement after first treatment on the reevaluation appointments. If surgery is needed, a bone substituting material may be necessary to fill the spaces where bone has been destroyed by the disease. Extraction of teeth might also be part of gum treatment if the disease is very severe. Re-treatment with antibiotics also may be necessary depending on the response after treatment. You are usually re-examined and receive additional cleanings every 3 to 6 months to ensure the disease does not come back."
Conventional periodontal treatment
Scaling and gum measurement will be taken to compare to the treated group.- If it is determined that you do not have this disease, a conventional cleaning is done, usually every 6 months. This is all part of normal clinical care.
Duval County Department of Health, Jacksonville
Leon County Health Department, Tallahassee
Gadsden County Health Department--Quincy Dental Clinic, Quincy
Dental Clinical Research Unit, University of Florida, Gainesville
Acorn Dental Clinic, Brooker
Azalea Dental Clinic, Gainesville
UF Hialeah Dental Clinic, Hialeah
Broward College, Fort Lauderdale
UF Naples Pediatric Dental Clinic, Naples
University of Kentucky, Lexington
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
University of Florida
OTHER