Safety and Efficacy of AVP-923 in the Treatment of Central Neuropathic Pain in Multiple Sclerosis

PHASE2CompletedINTERVENTIONAL
Enrollment

209

Participants

Timeline

Start Date

September 8, 2011

Primary Completion Date

September 26, 2013

Study Completion Date

September 26, 2013

Conditions
Central Neuropathic PainMultiple Sclerosis
Interventions
DRUG

AVP-923-45

AVP-923-45 (dextromethorphan 45 mg/quinidine 10 mg) capsules administered once daily for first 7 days followed by twice daily for 11 weeks of the study to complete 12 weeks of treatment.

DRUG

AVP-923-30

AVP-923-30 (dextromethorphan 30 mg/quinidine 10 mg) capsules administered once daily for first 7 days followed by twice daily for 11 weeks of the study to complete 12 weeks of treatment.

DRUG

AVP-923-20

AVP-923-20 (dextromethorphan 20 mg/quinidine 10 mg) capsules administered once daily for first 7 days followed by twice daily for 11 weeks of the study to complete 12 weeks of treatment.

DRUG

Placebo

Matching placebo capsules administered once daily for first 7 days followed by twice daily for 11 weeks of the study to complete 12 weeks of treatment.

Trial Locations (72)

10003

NYU-Hospital for Joint Diseases, New York

11794

SUNY at Stony Brook, Stony Brook

12208

Albany Medical Center Hospital, Albany

14642

University of Rochester, Rochester

17007

Hospital Universitari de Girona Dr. Josep Trueta, Girona

18711

Geisinger Health System, Wilkes-Barre

19107

Drexel University College of Medicine, Philadelphia

21287

Johns Hopkins University School of Medicine, Baltimore

22182

MS Center of Greater Washington, Vienna

23226

Neurological Associates, Henrico

28207

Carolinas Medical Center, Charlotte

30120

Hospital Universitario Virgen de la Arrixaca, El Palmar

30309

Shepard Center, Atlanta

32174

Neurology Associates of Ormond Beach, Ormond Beach

32751

Neurology Associates, PA, Maitland

32960

Geodyssey Research, LLC, Vero Beach

33060

Neurological Associates, Pompano Beach

33408

Laszlo J. Mate, MD, North Palm Beach

33612

University of South Florida, Tampa

33713

Suncoast Neuroscience Associates, Inc., St. Petersburg

34102

Collier Neurologic Specialists, Naples

35058

North Central Neurology Associates PC, Cullman

37064

Advanced Neurosciences Institute, Franklin

38010

Hospital Univ. Nuestra Sra. De La Candelaria, Santa Cruz de Tenerife

41009

Hospital Universitario Vírgen Macarena, Seville

44195

Cleveland Clinic Foundation, Cleveland

46256

Josephson Wallack Munshower Neurology, P.C., Indianapolis

48035

Michigan Neurology Associates, P.C., Clinton Township

48201

Wayne State University, Detroit

48202

Henry Ford Health System, Detroit

59405

Advanced Neurology Specialists, Great Falls

60062

Consultants in Neurology, Northbrook

60612

Rush-Presbyterian St. Luke's Medical Center, Chicago

66214

MidAmerica Neuroscience Institute, Lenexa

68506

Neurology Associates PC, Lincoln

73104

Oklahoma Medical Research Foundation, Oklahoma City

77030

Baylor College of Medicine, Houston

80045

University of Colorado, Aurora

84103

Rocky Mountain MS Clinic, Salt Lake City

85013

St. Joseph's Hospital Medical Center, Phoenix

92103

Coordinated Clinical Research, San Diego

92868

University of California, Irvine, Orange

94158

University of California, San Francisco, San Francisco

94705

Alta Bates Summit Medical Center, Berkeley

98122

Swedish Medical Center, Seattle

98405

MultiCare Health System, Tacoma

32082-4040

Neurologique Foundation, Ponte Vedra Beach

02215

Beth Israel Deaconess Medical Center, Boston

C1126AAB

Instituto de Neurologia Cognitiva, Ciudad Autonoma de Buenos Aires

C1280AEB

Hospital Britanico de Buenos Aires, Ciudad Autonoma de Buenos Aires

C1181ACH

Hospital Italiano, Ciudad Autónoma de Buenos Aires

C1015ABR

Instituto Argentino de Investigacion Neurologica, Ciudad de Buenos Aires

C1437JCH

Hospital Churruca-Visca, Buenos Aires

CP1117ABD

Fundación Argentina Contra las Enfermedades Neurológicas del Envejecimiento - FACENE, Buenos Aires

Unknown

Medeos - Centro de Medicina Integral e Investigación Clínica, Buenos Aires

Instituto de Neurología y Neurorrehabilitación del Litoral, Santa Fe

Fakultni nemocnice u sv. Anny v Brne, Brno

Niepubliczny Zaklad Opieki Zdrowotnej PROFILAKTYKA, Katowice

500 0

Fakultni nemocnice Hradec Kralove, Hradec Králové

586 33

Nemocnice Jihlava, prispevkova organizace, Jihlava

708 52

Fakultni Nemocnice Ostrava, Ostrava

128 21

Vseobecna fakultni nemocnice v Praze, Prague

41-250

Szpital Powiatowy w Czeladzi, Czeladź

80-803

Pomorskie Centrum Traumatologii im. M. Kopernika w Gdansku, Gdansk

26-200

Zespol Opieki Zdrowotnej w Konskich, Gmina Końskie

40-594

Diagnomed Clinical Research Sp. z.o.o., Katowice

40-752

Niepubliczny Zaklad Opieki Zdrowotnej NEURO-MEDIC, Katowice

62-064

Specjalistyczny Gabinet Neurologiczny, Plewiska

61-289

Niepubliczny Zaklad Opieki Zdrowotnej NEURO-KARD Ilkowski i Partnerzy Spolka Partnerska Lekarzy, Poznan

70-215

Osrodek Badan Klinicznych Indywidualnej Specjalistycznej Praktyki Lekarskiej, Szczecin

08003

Hospital del Mar, Barcelona

08035

Hospital Vall D´Hebron, Barcelona

Sponsors
All Listed Sponsors
lead

Avanir Pharmaceuticals

INDUSTRY