223
Participants
Start Date
April 18, 2011
Primary Completion Date
August 29, 2014
Study Completion Date
April 19, 2017
AMG386 plus PLD
AMG 386 is a first in class investigational anti angiogenic drug that provides potent and selective inhibition of angiopoietins. AMG 386 is designed to inhibit angiogenesis by sequestering Ang1 and Ang2, thereby preventing their interaction with the Tie2 receptor. Pegylated Liposomal Doxorubicin (Doxil/Caelyx) is a preparation of doxorubicin in a liposome that contains surface-grafted segments of the hydrophilic polymer methoxypolyethylene glycol associated with prolonged pharmacokinetics of the free drug. PLD 50 mg/m2 IV every 4 weeks (Q4W) and blinded AMG 386 15 mg/kg IV weekly (QW)
Placebo plus PLD
"Pegylated Liposomal Doxorubicin (Doxil/Caelyx) is a preparation of doxorubicin in a liposome that contains surface-grafted segments of the hydrophilic polymer methoxypolyethylene glycol associated with prolonged pharmacokinetics of the free drug.~PLD 50 mg/m2 IV every 4 weeks (Q4W) and blinded AMG 386 placebo IV weekly (QW)"
Research Site, Grafton, Auckland
Research Site, Budapest
Research Site, Budapest
Research Site, Vienna
Research Site, Vienna
Research Site, Geneva
Research Site, Wahroonga
Research Site, Copenhagen
Research Site, New Lambton Heights
Research Site, Edegem
Research Site, Herlev
Research Site, Leuven
Research Site, Footscray
Research Site, Parkville
Research Site, Tauranga
Research Site, Malvern
Research Site, East Bentleigh
Research Site, Miskolc
Research Site, Liège
Research Site, Linz
Research Site, Debrecen
Research Site, Auchenflower
Research Site, Greenslopes
Research Site, Namur
Research Site, Aarau
Research Site, Charleroi
Research Site, Innsbruck
Research Site, Szeged
Research Site, Libramont
Research Site, Chur
Research Site, Graz
Research Site, Graz
Research Site, Zurich
Research Site, Ieper
Research Site, Zalaegerszeg - Pozva
Research Site, Ghent
Research Site, New York
Research Site, Taipei
Research Site, Taipei
Research Site, Berlin
Research Site, Genova
Research Site, Rostock
Research Site, Abington
Research Site, Milan
Research Site, Milan
Research Site, Annandale
Research Site, Winston-Salem
Research Site, Durham
Research Site, Asheville
Research Site, Hanover
Research Site, Orlando
Research Site, Tampa
Research Site, Marburg
Research Site, Düsseldorf
Research Site, Essen
Research Site, Bonn
Research Site, Milwaukee
Research Site, West Allis
Research Site, Green Bay
Research Site, Saint Louis Park
Research Site, Sioux Falls
Research Site, Bismarck
Research Site, Evanston
Research Site, Frankfurt am Main
Research Site, Lyon
Research Site, Tainan City
Research Site, Tübingen
Research Site, San Antonio
Research Site, Fort Sam Houston
Research Site, Freiburg im Breisgau
Research Site, Amiens
Research Site, Napoli
Research Site, München
Research Site, München
Research Site, Avignon
Research Site, Poitiers
Research Site, Campobasso
Research Site, Los Angeles
Research Site, Erlangen
Research Site, Saint-Cloud
Research Site, San Francisco
Research Site, Singapore
Research Site, Singapore
Research Site, Norwalk
Research Site, Stamford
Research Site, London
Research Site, Toronto
Research Site, Toronto
Research Site, Hong Kong
Research Site, New Territories
Research Site, Roma
Research Site, Roma
Research Site, Roma
Research Site, Bialystok
Research Site, Gdansk
Research Site, Bratislava
Research Site, Bratislava
Research Site, Košice
Research Site, Prešov
Research Site, London
Research Site, London
Research Site, London
Research Site, Manchester
Research Site, Northwood
Research Site, Nottingham
Research Site, Poole
Lead Sponsor
Amgen
INDUSTRY