Plasmonic Nanophotothermal Therapy of Atherosclerosis

NACompletedINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

April 1, 2007

Primary Completion Date

April 1, 2009

Study Completion Date

August 1, 2016

Conditions
Stable AnginaHeart FailureAtherosclerosisMultivessel Coronary Artery Disease
Interventions
PROCEDURE

Transplantation of nanoparticles

60 patients into nanogroup with the use of 60/15-70/40 nm silica-gold nanoparticles (NPs) transplanted by endoscopic cardiac surgery in the composition of bioengineered on-artery patch grown on the basis of biopolymeric scaffold and host circulating CD45-CD34-CD73+CD105+ progenitor cells

PROCEDURE

Transplantation of iron-bearing nanoparticles

60 - into ferro-magnetic group with 60/15-70/40 nm silica-gold iron-bearing NPs with delivery in hand of magnetic navigation system

DEVICE

Stenting

60 - in sirolimus-eluting stenting control

Trial Locations (4)

620000

Ural Center of Modern Nanotechnologies, Institute of Natural Sciences, Ural Federal University, Yekaterinburg

620078

Transfiguration Clinic, Yekaterinburg

620144

Ural Institute of Cardiology, Yekaterinburg

1069CD

De Haar Research Task Force, Amsterdam

All Listed Sponsors
collaborator

Ural Institute of Cardiology

OTHER

collaborator

De Haar Research Task Force

INDUSTRY

collaborator

Ural Federal University

OTHER

collaborator

Transfiguration Clinic

UNKNOWN

lead

Ural State Medical University

OTHER

NCT01270139 - Plasmonic Nanophotothermal Therapy of Atherosclerosis | Biotech Hunter | Biotech Hunter