Amino-acid PET Versus MRI Guided Re-irradiation in Patients With Recurrent Glioblastoma Multiforme

PHASE2UnknownINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

July 31, 2011

Primary Completion Date

July 31, 2013

Study Completion Date

July 31, 2014

Conditions
Recurrent Glioma (Glioblastoma Multiforme)
Interventions
RADIATION

Radiation Therapy

Experimental intervention (Arm A): High-precision re-irradiation (stereotactic fractionated radiation therapy (SFRT) and/or image guided radiation therapy, (IGRT), total dose 39 Gy, 3 Gy/d, 5x/ week. Target volume delineation based on AA-PET: GTV = AA uptake on PET, clinical target volume (CTV) = GTV+3mm, PTV = CTV+2mm

RADIATION

Radiation Therapy

Control intervention (Arm B): High-precision re-irradiation (SFRT and/or IGRT), total dose 39 Gy, 3 Gy/d, 5x/ week. Target volume delineation based on T1Gd-MRI: GTV = contrast enhancement on T1Gd-MRI, CTV = GTV+3mm, PTV = CTV+2mm

Trial Locations (1)

79106

Department of Radiotherapy, University Hospital Freiburg, Freiburg I. Br.

Sponsors
All Listed Sponsors
collaborator

Clinical Trials Center Freiburg

UNKNOWN

collaborator

University of Freiburg

OTHER

collaborator

AG-NUK-RT

UNKNOWN

lead

University Hospital Freiburg

OTHER