NCT01238965View on ClinicalTrials.gov

Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Who Did Not Respond to Previous Fluorouracil-Based Chemotherapy

PHASE1TerminatedINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

October 31, 2010

Primary Completion Date

December 31, 2014

Study Completion Date

April 30, 2015

Conditions
Recurrent Colon CancerRecurrent Rectal CancerStage IV Colon CancerStage IV Rectal Cancer
Interventions
DRUG

panobinostat

Given orally

DRUG

fluorouracil

Given IV

DRUG

leucovorin calcium

Given IV

PROCEDURE

biopsy

Correlative studies

GENETIC

reverse transcriptase-polymerase chain reaction

Correlative studies

GENETIC

western blotting

Correlative studies

OTHER

laboratory biomarker analysis

Correlative studies

GENETIC

gene expression analysis

Correlative studies

GENETIC

RNA analysis

Correlative studies

GENETIC

polymorphism analysis

Correlative studies

Trial Locations (1)

90033

USC/Norris Comprehensive Cancer Center, Los Angeles

Sponsors

Collaborators (1)

Novartis
All Listed Sponsors
collaborator

Novartis

INDUSTRY

lead

University of Southern California

OTHER