Intensity-Modulated Radiation Therapy and Paclitaxel With or Without Pazopanib Hydrochloride in Treating Patients With Anaplastic Thyroid Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

123

Participants

Timeline

Start Date

October 28, 2010

Primary Completion Date

March 9, 2020

Study Completion Date

May 20, 2022

Conditions
Thyroid Gland Anaplastic Carcinoma
Interventions
RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

DRUG

Paclitaxel

Given IV

DRUG

Pazopanib Hydrochloride

Given PO

OTHER

Placebo Administration

Given PO

Trial Locations (130)

10065

Memorial Sloan Kettering Cancer Center, New York

10591

Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow

10604

Memorial Sloan Kettering Westchester, Harrison

11215

New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

15009

UPMC-Heritage Valley Health System Beaver, Beaver

15065

UPMC Cancer Center-Natrona Heights, Natrona Heights

15108

UPMC-Coraopolis/Heritage Valley Radiation Oncology, Moon Township

15132

UPMC Cancer Center at UPMC McKeesport, McKeesport

15213

UPMC-Presbyterian Hospital, Pittsburgh

15215

UPMC-Saint Margaret, Pittsburgh

15232

UPMC-Shadyside Hospital, Pittsburgh

15236

UPMC Jefferson Regional Radiation Oncology, Pittsburgh

15237

UPMC-Passavant Hospital, Pittsburgh

15243

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh

15301

UPMC Washington Hospital Radiation Oncology, Washington

15401

UPMC Uniontown Hospital Radiation Oncology, Uniontown

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

15901

UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown

16105

UPMC Jameson, New Castle

16346

UPMC Cancer Center at UPMC Northwest, Seneca

19107

Thomas Jefferson University Hospital, Philadelphia

19713

Christiana Gynecologic Oncology LLC, Newark

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19971

Beebe Health Campus, Rehoboth Beach

21204

Greater Baltimore Medical Center, Baltimore

21215

Sinai Hospital of Baltimore, Baltimore

23454

Sentara Virginia Beach General Hospital, Virginia Beach

23507

Sentara Norfolk General Hospital, Norfolk

23666

Sentara Cancer Institute at Sentara CarePlex Hospital, Hampton

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29605

Prisma Health Cancer Institute - Faris, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

33612

Moffitt Cancer Center, Tampa

35233

University of Alabama at Birmingham Cancer Center, Birmingham

35243

The Kirklin Clinic at Acton Road, Birmingham

39216

University of Mississippi Medical Center, Jackson

40202

The James Graham Brown Cancer Center at University of Louisville, Louisville

43210

Ohio State University Comprehensive Cancer Center, Columbus

44035

Mercy Cancer Center-Elyria, Elyria

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44129

University Hospitals Parma Medical Center, Parma

44130

UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights

44195

Cleveland Clinic Foundation, Cleveland

44203

Summa Health System - Barberton Campus, Barberton

44256

Summa Health Medina Medical Center, Medina

44304

Summa Health System - Akron Campus, Akron

44870

UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

46804

Radiation Oncology Associates PC, Fort Wayne

46805

Parkview Hospital Randallia, Fort Wayne

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48126

Henry Ford Medical Center-Fairlane, Dearborn

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48202

Henry Ford Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48377

Henry Ford Medical Center-Columbus, Novi

49007

West Michigan Cancer Center, Kalamazoo

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center, Madison

54143

Bay Area Medical Center, Marinette

54221

Holy Family Memorial Hospital, Manitowoc

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

55337

Fairview Ridges Hospital, Burnsville

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro Minnesota Community Oncology Research Consortium, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55905

Mayo Clinic in Rochester, Rochester

56201

Rice Memorial Hospital, Willmar

59101

Billings Clinic Cancer Center, Billings

66160

University of Kansas Cancer Center, Kansas City

70115

Touro Infirmary, New Orleans

70809

Mary Bird Perkins Cancer Center, Baton Rouge

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75235

Parkland Memorial Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

M D Anderson Cancer Center, Houston

84003

American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84143

LDS Hospital, Salt Lake City

84321

Logan Regional Hospital, Logan

84403

McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center, Provo

84720

Sandra L Maxwell Cancer Center, Cedar City

84770

Saint George Regional Medical Center, St. George

85004

Cancer Center at Saint Joseph's, Phoenix

85013

Saint Joseph's Hospital and Medical Center, Phoenix

85027

Arizona Oncology-Deer Valley Center, Phoenix

85260

Arizona Oncology Services Foundation, Scottsdale

94010

Mills-Peninsula Medical Center, Burlingame

94115

California Pacific Medical Center-Pacific Campus, San Francisco

UCSF Medical Center-Mount Zion, San Francisco

94143

UCSF Medical Center-Parnassus, San Francisco

94546

Eden Hospital Medical Center, Castro Valley

94589

Sutter Solano Medical Center/Cancer Center, Vallejo

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95603

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn

95661

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

95682

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park

95687

Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville

95816

Sutter Medical Center Sacramento, Sacramento

32224-9980

Mayo Clinic in Florida, Jacksonville

02118

Boston Medical Center, Boston

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

54301-3526

Green Bay Oncology at Saint Vincent Hospital, Green Bay

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH