Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases

PHASE2CompletedINTERVENTIONAL
Enrollment

113

Participants

Timeline

Start Date

March 31, 2011

Primary Completion Date

May 31, 2013

Study Completion Date

December 31, 2016

Conditions
Cognitive/Functional EffectsMetastatic CancerUnspecified Adult Solid Tumor, Protocol Specific
Interventions
RADIATION

intensity-modulated radiation therapy

30 Gy in 10 fractions to the whole brain using intensity-modulated radiation therapy excluding the hippocampal avoidance area. Bilateral hippocampal contours manually generated on the fused planning MRI CT image set by the treating physician according to protocol-specified contouring instructions. Hippocampal avoidance regions generated by three-dimensionally expanding the hippocampal contours by 5 mm.

Trial Locations (63)

12206

New York Oncology Hematology, PC at Albany Regional Cancer Care, Albany

16505

Regional Cancer Center - Erie, Erie

17325

Adams Cancer Center, Gettysburg

17405

York Cancer Center at Apple Hill Medical Center, York

19001

Rosenfeld Cancer Center at Abington Memorial Hospital, Abington

19010

Bryn Mawr Hospital, Bryn Mawr

19096

Lankenau Cancer Center at Lankenau Hospital, Wynnewood

19713

CCOP - Christiana Care Health Services, Newark

21201

Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore

22908

University of Virginia Cancer Center, Charlottesville

30309

Piedmont Hospital, Atlanta

32177

Florida Cancer Center - Palatka, Palatka

32207

Baptist Cancer Institute - Jacksonville, Jacksonville

33136

University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami

33176

Baptist-South Miami Regional Cancer Program, Miami

35294

UAB Comprehensive Cancer Center, Birmingham

44130

Southwest General Health Center, Middleburg Heights

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

45601

Adena Regional Medical Center, Chillicothe

46202

Methodist Cancer Center at Methodist Hospital, Indianapolis

46526

Center for Cancer Care at Goshen General Hospital, Goshen

55905

Mayo Clinic Cancer Center, Rochester

57701

Rapid City Regional Hospital, Rapid City

60612

Rush University Medical Center, Chicago

61637

OSF St. Francis Medical Center, Peoria

63110

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis

68198

Nebraska Medical Center, Omaha

73104

Oklahoma University Cancer Institute, Oklahoma City

76022

Texas Oncology, PA at Harris Center HEB, Bedford

76104

Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital, Fort Worth

77024

Memorial Hermann Hospital - Memorial City, Houston

77479

Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land, Sugar Land

84112

Huntsman Cancer Institute at University of Utah, Salt Lake City

84157

Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray

84403

Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden

85381

Arizona Center for Cancer Care - Peoria, Peoria

85704

Arizona Oncology - Tucson, Tucson

90048

Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles

90822

Veterans Affairs Medical Center - Long Beach, Long Beach

95815

Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento

95817

University of California Davis Cancer Center, Sacramento

97401

Willamette Valley Cancer Center - Eugene, Eugene

98101

CCOP - Virginia Mason Research Center, Seattle

99202

Cancer Care Northwest - Spokane South, Spokane

85259-5499

Mayo Clinic Scottsdale, Scottsdale

85724-5024

Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson

46202-5289

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

01923

NSMC Cancer Center - Peabody, Danvers

48201-1379

Barbara Ann Karmanos Cancer Institute, Detroit

59107-7000

Billings Clinic - Downtown, Billings

07039

St. Barnabas Medical Center Cancer Center, Livingston

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

44309-2090

Summa Center for Cancer Care at Akron City Hospital, Akron

44106-5065

Case Comprehensive Cancer Center, Cleveland

43210-1240

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center, Columbus

97213-2967

Providence Cancer Center at Providence Portland Medical Center, Portland

17033-0850

Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center, Hershey

19107-5541

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia

77030-4009

M. D. Anderson Cancer Center at University of Texas, Houston

23298-0037

Virginia Commonwealth University Massey Cancer Center, Richmond

N6A 4L6

London Regional Cancer Program at London Health Sciences Centre, London

M5G 2M9

Princess Margaret Hospital, Toronto

S7N 4H4

Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

NRG Oncology

OTHER

lead

Radiation Therapy Oncology Group

NETWORK