Perioperative Vs. Preoperative Chemotherapy With Surgery in the Squamous Carcinoma of Esophagus

PHASE1CompletedINTERVENTIONAL
Enrollment

350

Participants

Timeline

Start Date

January 31, 1997

Primary Completion Date

December 31, 2008

Study Completion Date

January 31, 2010

Conditions
Squamous Carcinoma of EsophagusEsophagus Disorders
Interventions
DRUG

Paclitaxel; Cisplatin; 5-Fluorouracil

Two preoperative cycles with Paclitaxel 200 mg/m² d1, Cisplatin 60 mg/m² d1, 5-Fluorouracil 700 mg/m² d1-5 repeated every 3 weeks followed by resection

DRUG

Paclitaxel; Cisplatin; 5-Fluorouracil; Capecitabine

Two postoperative cycles with Paclitaxel 200 mg/m²/day d1, Cisplatin 60 mg/m²/day d1, 5-Fluorouracil 700 mg/m²/day d1-5 repeated every 3 weeks Among patients with no responses to preoperative chemotherapy, Capecitabine 625 mg/m² twice-daily dose as alternatives to infused 5-Fluorouracil in the postoperative chemotherapy regimen

Trial Locations (1)

710061

First Affiliated Hospital of College of Medicine of Xi'an Jiao Tong University, Xi'an

All Listed Sponsors
lead

Xi'an Jiaotong University

OTHER

NCT01225523 - Perioperative Vs. Preoperative Chemotherapy With Surgery in the Squamous Carcinoma of Esophagus | Biotech Hunter | Biotech Hunter