A Safety and Efficacy Study of Farletuzumab in Participants With Adenocarcinoma of the Lung

PHASE2CompletedINTERVENTIONAL
Enrollment

130

Participants

Timeline

Start Date

June 27, 2011

Primary Completion Date

December 15, 2012

Study Completion Date

November 1, 2013

Conditions
Adenocarcinoma of the Lung
Interventions
BIOLOGICAL

Farletuzumab

"Combination Therapy: Farletuzumab 7.5 mg/kg will be administered intravenously on Cycle 1, Week 1 and Cycle 1, Week 2 (loading dose). Beginning on Cycle 2, Week 1, farletuzumab (7.5 mg/kg) will be administered intravenously on Week 1 of all additional cycles.~Monotherapy: Farletuzumab 7.5 mg/kg will be administered intravenously on Week 1 of every 3-week cycle until disease progression."

OTHER

Placebo

"Combination Therapy: Placebo will be administered intravenously on Cycle 1, Week 1 and Cycle 1, Week 2 (loading dose). Beginning on Cycle 2, Week 1, placebo will be administered IV on Week 1 of all additional cycles.~Monotherapy: Placebo will be administered intravenously on Week 1 of every 3-week cycle until disease progression."

DRUG

Carboplatin

Carboplatin will be administered intravenously to achieve area under the serum concentration-time curve of 5 to 6 mg/mL\^min \[AUC5-6\].

DRUG

Paclitaxel

Paclitaxel 200 mg/m\^2 will be administered intravenously.

DRUG

Pemetrexed

Pemetrexed 500 mg/m\^2 will be administered intravenously.

DRUG

Cisplatin

Cisplatin 75 mg/m\^2 will be administered intravenously.

Trial Locations (93)

2485

The Tweed Hospital, Tweed Heads

2500

Southern Medical Day Oncology Care Centre, Wollongong

3002

Epworth Healthcare, Richmond

3128

Box Hill Hospital, Box Hill

3199

Frankston Hospital, Oncology Day Unit, Frankston

4029

Royal Brisbane and Women's Hospital, Dept. of Medical Oncology, Brisbane

4102

Princess Alexandra Hospital, Woolloongabba

5000

Royal Adelaide Hospital, Cancer Centre, Adelaide

5011

The Queen Elizabeth Hospital, Woodville South

5042

Flinders Medical Centre, Dept. of Oncology, Bedford Park

5112

Lyell McEwin Hospital, Elizabeth Vale

6160

Fremantle Hospital, Fremantle

10043

"Azienda Ospedaliero-Univesitaria San Luigi Gonzaga", Orbassano

11432

Queens Hospital Center, Jamaica

13210

Syracuse Veterns Affairs Medical Center, Syracuse

14165

HELIOS Klinikum Emil von Behring, Berlin

16132

Istituto Nazionale per la Ricerca sul Cancro, Genova

17325

Gettysburg Cancer Center, Gettysburg

18015

St. Luke's Cancer Center Associates, Bethlehem

20892

National Cancer Institute, Bethesda

21044

Maryland Oncology Hematology, P.A., Columbia

21075

Asklepios Klinik Harburg, Hamburg

22031

Virginia Cancer Specialists, PC, Fairfax

23704

Delta Hematology Oncology Associates, PC, Portsmouth

28040

Fundación Jiménez Díaz, Madrid

29010

Hospital Regional Carlos Haya, Málaga

32024

Cancer Care of North Florida, Lake City

32429

Johannes-Wesling-Klinikum Minden, Minden

32806

MD Anderson Cancer Center-Orlando, Orlando

33316

Broward General Medical Center, Fort Lauderdale

33441

Medical Specialists of the Palm Beaches, Deerfield Beach

33486

Center for Hematology-Oncology, Boca Raton

34474

Ocala Oncology Center, PL, Ocala

34655

Florida Cancer Institute-New Hope, New Port Richey

37203

Tennessee Oncology, PLLC, Nashville

40503

Baptist Health System, Inc., Lexington

41701

Kentucky Cancer Center, Hazard

46321

The Community Hospital, Munster

47713

Deaconess Clinic Downtown, Evansville

48336

Detroit Clinical Research Center, Farmington Hills

54313

Cancer Team Bellin Health, Green Bay

55043

Ospedale Unico Versilia, Lido di Camaiore

60488

Krankenhaus Nordwest GmbH, Frankfurt am Main

60637

University of Chicago Medical Center, Chicago

62801

University Hematology Oncology, Inc., Centralia

69126

Universitätsklinikum Heidelberg, Heidelberg

70006

Hematology and Oncology Specialists, LLC, Metairie

71301

Christus Saint Frances, Cabrini Hospital, Cabrini Cancer Center, Alexandria

74245

Klinik Löwenstein gGmbH, Löwenstein

76022

Texas Oncology - Bedford, Bedford

76712

Texas Oncology - Waco, Waco

77055

Houston Cancer Institute, Houston

77479

Northwest Cancer Center, Sugar Land

77555

University of Texas Medical Branch, Galveston

80131

A.O. Seconda Università degli Studi di Napoli, Napoli

82131

Asklepios Fachkliniken München-Gauting, Gauting

85224

Ironwood Cancer and Research Center, Chandler

90025

Glendale Adventist Medical Center, Los Angeles

90640

Clinical Trials and Research Associates, Inc., Montebello

91750

Wilshire Medical Oncology Group, La Verne

92056

North Country Oncology-Hematology, Oceanside

92093

Moores University of California San Diego Cancer Center, La Jolla

93454

Central Coast Medical Oncology, Santa Maria

93720

Cancer Care Associates of Fresno Medical Group, Inc., Fresno

94115

Pacific Hematology Oncology Associates, San Francisco

94904

California Cancer Care, Inc., Greenbrae

95020

Medical Oncology Hematology, Gilroy

97401

Willamette Valley Cancer Institute and Research Center, Eugene

98101

Virginia Mason Medical Center, Seattle

99204

Rockwood Cancer Treatment Center, Spokane

99208

Medical Oncology Associates, PS, Spokane

115478

Cancer Research Center n.a. N.N. Blokhin, Moscow

143423

City Oncology Hospital # 62, Moscow

420029

Republican Clinical Oncologic Dispensary of Ministry of health of Republic Tatarstan, Kazan'

85306-4666

Arizona Center for Hematology Oncology, Glendale

90210-5501

Providence Health System, Beverly Hills

80218-1237

Rocky Mountain Cancer Centers, LLP, Denver

06902-3628

Hematology Oncology Associates, P.C., Stamford

01201

Berkshire Hematology Oncology, PC, Pittsfield

07631

Englewood Hospital and Medical Center, Englewood

75075-7787

Texas Oncology - Plano East, Plano

75702-8363

Texas Oncology - Tyler, Tyler

L4M 6M2

Royal Victoria Hospital, Barrie

N2G 1G3

Grand River Regional Cancer Centre, Kitchener

MSG 2L7

Princess Margaret Hospital, Toronto

H3T 1E2

Jewish General Hospital, Montreal

06120

Städtisches Krankenhaus Martha-Maria Halle Dölau gGmbH, Halle

87-100

Wojewódzki Szpital Zespolony im. L. Rydygiera w Toruniu Szpital Dzieciecy, Torun

02-781

Centrum Onkologii - Instytut im. M. Sklodowskiej-Curie w Warszawie, Warsaw

70-891

Specjalistyczny Szpital im. Alfreda Sokolowskiego, Szczecin

08035

Hospital General Vall d'Hebron, Barcelona, Barcelona

08036

Hospital Clinic i Provincial de Barcelona, Barcelona

08916

Hospital Germans Trías i Pujol, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Morphotek

INDUSTRY