Dose Escalation of Hypofractionated Radiation Therapy in Patients With Metastatic Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

63

Participants

Timeline

Start Date

January 31, 2005

Primary Completion Date

March 31, 2018

Study Completion Date

March 31, 2018

Conditions
TumorCancerMelanomaSarcomaCarcinoma
Interventions
RADIATION

Hypofractionated RT

"RT to site of metastatic disease for three fractions separated by 3 to 8 days. Doses of radiation will increase as follows in order to determine the MTD in Gy:~For all sites the dose levels are as follows:~1. 8 Gy/ fraction x 3 fractions = 24 Gy~2. 10 Gy/fraction x 3 fractions = 30 Gy~3. 12 Gy/fraction x 3 fractions = 36 Gy~4. 14 Gy/fraction x 3 fractions = 42 Gy~5. 16 Gy/fraction x 3 fractions = 48 Gy~6. 18 Gy/fraction x 3 fractions = 52 Gy~7. 20 Gy/fraction x 3 fractions = 60 Gy"

Trial Locations (1)

60637

University of Chicago, Chicago

All Listed Sponsors
lead

University of Chicago

OTHER

NCT01215500 - Dose Escalation of Hypofractionated Radiation Therapy in Patients With Metastatic Cancer | Biotech Hunter | Biotech Hunter