1,717
Participants
Start Date
September 16, 2010
Primary Completion Date
September 30, 2013
Study Completion Date
February 14, 2019
Enzalutamide
Participants received enzalutamide 160 mg, administered as four 40-mg capsules, once per day by mouth. Study drug treatment continued until disease progression (evidence of radiographic progression, a skeletal-related event, or clinical progression) and the initiation of a cytotoxic chemotherapy or an investigational agent, unacceptable toxicity, or withdrawal.
Placebo
Participants received placebo, administered as four capsules, once per day by mouth. Study drug treatment continued until disease progression (evidence of radiographic progression, a skeletal-related event, or clinical progression) and the initiation of a cytotoxic chemotherapy or an investigational agent, unacceptable toxicity, or withdrawal.
Medizinische Universitaet Wien, Vienna
Cliniques Universitaires Saint-Luc, Brussels
Frederiksberg Hospital, Frederiksberg
Prince of Wales Hospital, Randwick
Royal North Shore Hospital, Department of Medical Oncology, St Leonards
Sydney Adventist Hospital, Sydney
Australian Clinical Trials Pty Ltd, Wahroonga
SAN Pathology, Wahroonga
SAN Radiology, Wahroonga
Concord Repatriation General Hospital, Concord
Westmead Hospital, Westmead
Liverpool Hospital, Liverpool
Rigshospitalet, Copenhagen
St George Private Hospital, Kogarah
Calvary Mater Newcastle, Waratah
North Coast Cancer Institute, Port Macquarie
Lismore Base Hospital, Lismore Cancer Care and Haematology Unit, Lismore
Herlev Hospital, Herlev
Peter MacCallum Cancer Centre, Melbourne
UZ Leuven - University Hospital Gasthuisberg, Leuven
Peter MacCallum Cancer Centre, East Melbourne
Sunshine Hospital, St Albans
Austin Hospital, Heidelberg
Eastern Health, Box Hill
MIA Box Hill Radiology, Box Hill
Oncology Eastern Clinical Research Unit (ECRU), Box Hill
Pharmacy Department, Box Hill
Cabrini Hospital Malvern, Malvern
Cabrini Radiology, Malvern
MDI Chemer, Malvern
Monash Health Translation Precinct, Clayton
Cabrini Hospital Brighton, Brighton
Barwon Health, Geelong Hospital, Geelong
Jessaziekenhuis, Hasselt
Bendigo Health, Bendigo Hospital, Bendigo
Bendigo Health Medical Imaging, Bendigo
Centre Hospitalier Universitaire de Liege-Urologie, Liège
Roskilde Sygehus, Roskilde
University of Queensland Centre for Clinical Research (UQCCR), Herston
Krankenhaus der Barmherzigen Schwestern Linz, Linz
Nuclear Medicine and Imaging Department, Herston
Icon Cancer Care Chermside, Chermside
Heart Care Partners, Auchenflower
Icon Cancer Care Wesley, Auchenflower
River City Pharmacy, Auchenflower
Icon Cancer Care South Brisbane, South Brisbane
Icon Cancer Foundation, South Brisbane
Mater Private Cardiology, South Brisbane
Ordination Dr. Fink, Salzburg
Salzburger Universitatsklinikum, Salzburg
Adelaide Cancer Centre, Kurralta Park
APHS Pharmacy, Kurralta Park
Ashford Cancer Centre Research, Kurralta Park
Cancer Care SA Pty Ltd, Kurralta Park
Aarhus Universitetshospital, Aarhus N
AZ Groeninge, Campus KL, Kortrijk
AZ Sint-Lucas, Ghent
Aalborg Hospital Nord, Aalborg
The Mount Sinai Medical Center, New York
Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano
Memorial Sloan-Kettering Cancer Center, New York
National Cancer Center, Goyang-si
Charite-Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin
Seoul National University Bundang Hospital, Seongnam-si
Complejo Hospitalario Universitario A Coruna, A Coruña
UPMC Presbyterian, Pittsburgh
UPMC Hillman Cancer Center, Pittsburgh
Abramson Cancer Center of the University of Pennsylvania at Perelman Center for Advanced Medicine, Philadelphia
Martini-Klinik am UKE Gmbh, Hamburg
Urologikum Hamburg, Hamburg
Virginia Oncology Associates, Virginia Beach
Virginia Oncology Associates, Norfolk
Virginia Oncology Associates, Newport News
Virginia Oncology Associates, Hampton
Azienda Socio Sanitaria Territoriale di Cremona, Cremona
Cancer Centers of North Carolina, Cary
Cancer Centers of North Carolina, Raleigh
Duke University Medical Center, Durham
Investigational Chemotherapy Services, Durham
Hospital Universitario Ramon y Cajal, Madrid
Hospital Madrid Norte Sanchinarro, Madrid
Levine Cancer Institute, Charlotte
Levine Cancer Institute - Main, Charlotte
Levine Cancer Institute - Southpark, Charlotte
Levine Cancer Institute - University, Charlotte
Levine Cancer Institute - Ballantyne, Charlotte
Hematology / Oncology MUSC Hollings Cancer Center, Charleston
Medical University of South Carolina - Urology Services, Charleston
MUSC Department of Radiology, Charleston
MUSC Urology Ambulatory Care, Charleston
MUSC Hematology / Oncology Medical Specialty Associates, East Cooper Medical Arts Center 3rd Floor, Mt. Pleasant
MUSC Urology Medical Specialty Associates, East Cooper Medical Arts Center 3rd Floor, Mt. Pleasant
Medizinische Hochschule Hannover, Hanover
Clínica Universidad de Navarra, Pamplona
Bnai Zion Medical Center, Haifa
Clinique Pasteur, Toulouse
Lynn Cancer Institute Center for Hematology Oncology, Boca Raton
Tampere University Hospital, Tampere
Centre Eugene Marquis-Service d'Oncologie Medicale, Rennes
University of Alabama at Birmingham, Birmingham
University of Alabama at Birmingham, Birmingham
Staedtisches Klinikum Braunschweig gGmbH, Braunschweig
Jewish Hospital & St. Mary's Healthcare, Inc., Louisville
Institut de Cancerologie Lucien Neuwirth, Saint-Priest-en-Jarez
Centre de Recherche Clinique, Saint-Herblain
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), Meldola
Ospedale G.B. Morgagni, Forlì
Universitaetsklinikum Muenster, Münster
Karmanos Cancer Institute, Detroit
Karmanos Cancer Institute Weisberg Cancer Treatment Center, Farmington Hills
ICO Paul Papin, Angers
Rabin Medical Center, Petah Tikva
Azienda USL8-Presidio Ospedaliero S.Donato, Arezzo
The Chaim Sheba Medical Center, Ramat Gan
University of Wisconsin Hospital and Clinics, Madison
Mayo Clinic, Rochester
Northwestern Medical Faculty Foundation, Chicago
Northwestern Memorial Hospital, Chicago
BJH Pharmacy, St Louis
Barnes-Jewish Hospital, St Louis
Washington University School of Medicine, St Louis
Barnes-Jewish West County Hospital, Creve Coeur
Barnes-Jewish St. Peters Hospital, City of Saint Peters
Universitaetsklinikum des Saarlandes, Homburg/Saar
Nebraska Methodist Hospital, Omaha
Universitaetsklinikum Mannheim, Klinik fuer Urologie, Mannheim
Universitaetsklinikum Heidelberg, Klinik Fuer Urologie, Heidelberg
Assaf Harofe Medical Center, Beer Yaakov
Centre Jean Bernard - Clinique Victor Hugo, Le Mans
Universitaetsklinikum Tuebingen, Universitaetsklinik fuer Urologie, Tübingen
Institut Curie, Paris
Groupe Hospitalier La Pitie Salpetriere, Paris
UT Southwestern Medical Center at Dallas, Dallas
Hopital Europeen Georges Pompidou, Paris
Anschutz Cancer Center Pavilion Pharmacy, Aurora
University of Colorado Hospital, Anschutz Cancer Pavilion, Aurora
Clinique Rhone Durance, Avignon
Soroka University Medical Center, Beersheba
The University of Arizona Cancer Center-North Campus, Tucson
The University of Arizona Cancer Certer-North Campus, Tucson
CHD Vendee, La Roche-sur-Yon
Universitaetsklinikum Ulm, Ulm
Keck Hospital of USC, Los Angeles
LAC&USC Medical Center, Los Angeles
USC/Norris Comprehensive Cancer Center / Investigational Drug Services, Los Angeles
USC/Norris Comprehensive Cancer Center, Los Angeles
Ronald Reagan UCLA Medical Center Drug Information Center Department of Pharmaceutical Services, Los Angeles
UCLA Clark Urology Clinic, Los Angeles
Oulu University Hospital, Oulu
Cancer Center Oncology Medical Group, La Mesa
North County Oncology Medical Clinic, Inc, Oceanside
Medical Oncology Associates-SD, San Diego
Sharp Memorial Hospital Investigational Pharmacy, San Diego
Sharp Rees-Stealy, San Diego
Klaipeda University Hospital, Klaipėda
Kliniken Nordoberpfalz AG, Klinikum Weiden, Weiden in Der Oberpfalz
Stanford University Medical Center, Stanford
Institut Gustave Roussy, Villejuif
UC Davis Medical Center, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
Portland VA Medical Center Laboratory, Portland
Seattle Cancer Care Alliance, Seattle
University of Washington Medical Center, Seattle
Russian Academy of Medical Sciences Institution, Moscow
Department of Urology, National University Hospital, Singapore
Singapore General Hospital, Singapore
North-Western State Medical University named after I.I.Mechnikov of the Ministry of Healthcare, Saint Petersburg
State Educational Institution of Higher Professional Education, Saint Petersburg
State healthcare institute, Saint Petersburg
Chonnam National University Hwasun Hospital, Hwasun-eup, Hwasun-gun
Jikei University Hospital, Tokyo
Nippon Medical School Hospital, Bunkyo-ku
Cancer Institute Hospital, Koutou-ku
Showa University Hospital, Shinagawa-ku
Keio University Hospital, Shinjyuku-ku
Nihon University Itabashi Hospital, Itabashi-ku
Yokohama City University Hospital, Yokohama
Chiba Cancer Center, Chiba
Osaka International Cancer Institute, Osaka
Osaka City University Hospital, Osaka
Osaka University Hospital, Suita-shi
Kindai University Hospital, Ōsaka-sayama
Kyoto University Hospital, Kyoto
Yamaguchi University Hospital, Ube-shi
Tokushima University Hospital, Tokushima
Kyushu University Hospital, Fukuoka
Nagasaki University Hospital, Nagasaki
Niigata University Medical and Dental Hospital, Niigata
Tohoku University Hospital, Sendai
Yamagata Prefectural Central Hospital, Yamagata
Brigham & Women's Hospital, Boston
Beth Israel Deaoness Medical Center, Boston
Dana Farber Cancer Institute, Boston
Alberta Health Services - Cancer Care, Tom Baker Cancer Centre, Calgary
Tom Baker Cancer Centre - Holy Cross Site, Calgary
Cross Cancer Institute, Edmonton
British Columbia Cancer Agency, Sindi Ahluwalia Hawkins, Centre for the Southern Interior, Kelowna
Vancouver Prostate Centre, Vancouver
Vancouver Island Health Authority-Royal Jubilee Hospital Medical Imaging, Victoria
British Columbia Cancer Agency - Vancouver Island Centre, Victoria
Manitoba Prostate Centre, Winnipeg
QEII Health Sciences Centre, Nova Scotia Cancer Centre., Halifax
QEII Health Sciences Centre, Halifax
QEII Health Sciences Centre, Halifax
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton
London RegCancer Program, London Health Sciences Centre, London
The Ottawa Hospital Cancer Centre, General Campus, Ottawa
The Ottawa Hospital Cancer Centre, Ottawa
Sunnybrook Health Sciences Centre, Toronto
Princess Margaret Cancer Centre, Toronto
Centre Hospitalier de l'Universite de Montreal, Montreal
CHU de Quebec - L'Hotel-Dieu de Quebec, Québec
Centre de recherche clinique el evaluative en oncologie (CRCEO), Québec
Docrates Clinic, Helsinki
Helsinki University Central Hospital, Helsinki
Hopital Civil, Strasbourg
Institut Bergonie, Bordeaux
Institut Bergonie, Bordeaux
Centre Leon Berard, Lyon
HIA Begin, Service de Medecine Interne et Oncologie, Saint-Mandé
Universitaetsklinikum Carl Gustav Carus Dresden an der, Dresden
Azienda Ospedaliera San. Camillo Forlanini, Rome
Kyorin University Hospital, Mitaka-shi
Division of Oncourology, National Cancer Institute, Vilnius
Vrije Universiteit Medical Center, Department of Medical Oncology, Amsterdam
Catharina Ziekenhuis, Eindhoven
University Medical Center Groningen, Department of Urology, Groningen
UMC St. Radboud, Nijmegen
Wielkopolskie Centrum Onkologii, Poznan
EMC Instytut Medyczny S.A., Wroclaw
Apteka Szpitalna, Gdansk
Uniwersyteckie Centrum Kliniczne, Gdansk
Niepubliczny Zaklad Opieki Zdrowotnej, Mysłowice
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Tramatologii im. M.Kopernika w Lodzi, Lodz
Fakultna nemocnica s poliklinikou F.D. Roosevelta B. bystrica, Banská Bystrica
CUIMED s.r.o., Bratislava
Univerzitna Nemocnica Martin, Martin
UROEXAM, spol. s r.o. urologicka ambulancia, Nitra
Poliklinika Sekcov, wesper, s.r.o., Prešov
UROCENTRUM MILAB s.r.o., Prešov
Samsung Medical Center, Gangnam-gu
Asan Medical Center, Songpa-gu
Severance Hospital, Yonsei University Health System, Seoul
Gangnam Severance Hospital, Yonsei University Health System, Seoul
Hospital Son Espases, Palma de Mallorca
Hospital Universitario German Trias i Pujol, Badalona
Althaia Xarxa Asistencial Manresa, Manresa
Hospital del Mar, Barcelona
Hospital Vall d'Hebron, Barcelona
Hospital Clinic i Provincial, Barcelona
Corporacio Sanitaria Parc Tauli, Sabadell(Barcelona)
Sahlgrenska University Hospital, Gothenburg
Skane University Hospital, Malmo
Orebro University Hospital, Örebro
Karolinska University Hospital Solna, Stockholm
Umea University Hospital, Umeå
Bishops Wood Hospital, Northwood
Mount Vernon Hospital, Northwood
Oxford University Hospitals NHS Trust, Oxford
Royal Marsden Hospital, Sutton
Northern Centre for Cancer Care, Newcastle upon Tyne
Velindre Cancer Centre, Cardiff
Clatterbridge Cancer Centre NHS Foundation Trust, Bebington
Clinical Investigations and Research Unit, Royal Sussex County Hospital, Brighton, East Sussex
University Hospitals Bristol NHS Foundation Trust, Bristol
Edinburgh Cancer Centre, Edinburgh
University College London Hospital NHS Trust, London
Guy's and St Thomas' NHS Foundation Trust, London
Imperial College Healthcare NHS Trust, London
Lead Sponsor
Collaborators (1)
Astellas Pharma Inc
INDUSTRY
Medivation LLC, a wholly owned subsidiary of Pfizer Inc.
INDUSTRY
Pfizer
INDUSTRY