Axitinib For The Treatment Of Advanced Hepatocellular Carcinoma

PHASE2CompletedINTERVENTIONAL
Enrollment

224

Participants

Timeline

Start Date

December 6, 2010

Primary Completion Date

March 3, 2014

Study Completion Date

December 20, 2016

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Axitinib (AG-013736)

Axitinib \[tablet, 1 mg, 5 mg\] will be given twice daily \[BID\] with continuous dosing; duration is approximately 3-6 months; starting dose is 5 mg BID

OTHER

Best Supportive Care

BSC may include medications and supportive measures deemed necessary to palliate disease related symptoms and improve quality of life.

DRUG

Placebo

Placebo \[tablet, 1 mg, 5 mg\] will be given twice daily \[BID\] with continuous dosing; duration is approximately 3-6 months; starting dose is 5 mg BID

OTHER

Best Supportive Care

BSC may include medications and supportive measures deemed necessary to palliate disease related symptoms and improve quality of life.

Trial Locations (77)

100

National Taiwan University Hospital, Taipei

333

Chang Gung Medical Foundation Linkou Branch, Taoyuan District

500

Changhua Christian Hospital, Changhua

704

National Cheng Kung University Hospital, Tainan City

736

Chi-Mei Medical Center LiouYing, Tainan City

833

Chang Gung Medical Foundation - Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

1083

Semmelweis Egyetem I.sz. Belgyógyászati Klinika, Budapest

4000

CHC Clinique Saint-Joseph, Liège

6720

Szegedi Tudományegyetem Onkoterápiás Klinika, Szeged

9000

Universitair Ziekenhuis Gent, Ghent

13005

UPCET-CIC Timone, Marseille

13353

Medizinische Klinik mit Schwerpunkt, Berlin

14033

CHU Cote de Nacre, Caen

19104

Hospital of the University of Pennsylvania, Philadelphia

Penn Presbyterian Medical Center, Philadelphia

27100

Unita Operativa Oncologia Medica IRCCS Fondazione Salvatore Maugeri, Pavia

31059

CHRU de Purpan., Toulouse

32804

Florida Hospital Transplant Center, Liver Unit, Orlando

33075

Hopital Saint André, Bordeaux

33612

Moffitt Cancer Center & Research Institute, Tampa

34295

CHRU Montpellier-Hopital Saint Eloi - Departement Oncologie Medicale, Montpellier

35042

Centre Eugène Marquis, Rennes

40138

Istituto di Ematologia ed Oncologia Medica, Lorenzo ed Ariosto Seragnoli,, Bologna

"Policlinico S.Orsola-Malpighi Dipartimento di Ematologia e Scienze Oncologiche L. E A. Seragnoli", Bologna

40705

Taichung Veterans General Hospital, Taichung

47014

Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori IRST, Meldola (FC)

48109

University of Michigan, Ann Arbor

53100

Azienda Ospedaliera Universitaria Senese Policlinico Santa Maria aile Scotte, Siena

53105

Universitätsklinikum Bonn, Bonn

55043

Ospedale Versilia,Oncologia Medica, Lido Di Camaiore (LU)

68114

Nebraska Methodist Hospital, Omaha

69317

Hopital De La Croix-Rousse, Lyon

75012

Hôpital Saint Antoine, Paris

80054

Centre Hospitalier Universitaire d'Amiens, Amiens

81377

Klinikum der Ludwig-Maximilians-Universitaet , Campus Grosshadern, München

86169

Comprehensive Cancer Centers of Nevada, Las Vegas

89119

Comprehensive Cancer Centers of Nevada, Las Vegas

92037

UCSD Medical Center- La Jolla, La Jolla

92093

Moores UCSD Cancer Center, La Jolla

92103

UCSD Medical Center- Hillcrest, San Diego

92118

Bichat-Beaujon Service Inter Hospitalier De Cancerologie, Clichy

92868

University of California Irvine Medical Center, Orange

94704

Alta Bates Summit Comprehensive Cancer Center, Berkeley

100071

The PLA 307 Hospital, Beijing

200032

Zhongshan Hospital Fudan University, Shanghai

210002

Nanjing Bayi Hospital, Nanjing

210009

Jiang Su Cancer Hospital, Nanjing

230022

The First Affiliated Hospital of Anhui Medical University, Hefei

310016

Sir Run Run Shaw Hospital of College of Medicine of Zhejiang University, Hangzhou

510080

Guangdong General Hospital, Guangzhou

1010062

Sasaki Foundation Kyoundo Hospital, Chiyoda-Ku

5008513

Gifu Municipal Hospital, Gifu

06200

Hôpital L'Archet Ii, Nice

Unknown

Prince of Wales Hospital, Shatin, N.T.

Queen Mary Hospital, Hong Kong

00168

Policlinico Universitario Agostino Gemelli, Roma

Unità Operativa Oncologica Medica, Roma

464-8681

Aichi Cancer Center Central Hospital, Diagnostic and Interventional Radiology, Nagoya

260-0858

Chiba University Hospital, Chiba

920-8641

Kanazawa University Hospital, Kanazawa

589-8511

Kinki University Hospital, Ōsaka-sayama

411-8777

Shizuoka Cancer Center, Suntou-gun

173-8610

Nihon University Itabashi Hospital, Itabashi-Ku

400-8506

Yamanashi Prefectural Central Hospital, Kofu

975 17

Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica, Banská Bystrica

833 10

Narodny onkologicky ustav, Bratislava

058 01

POKO Poprad s.r.o., Poprad

058 45

Nemocnica Poprad, a.s., Poprad

410-769

National Cancer Center/ Center for Liver Cancer, Goyang-si

135-710

Samsung Medical Center, Division of Hematology-Oncology, Department of Medicine, Seoul

138-736

Asan Medical Center, Division of Oncology, Department of Internal Medicine, Seoul

M20 9BX

The Christie NHS Foundation Trust, Withington

L6 7BA

Clatterbridge Centre for Oncology NHS Foundation Trust, Liverpool

L69 3GA

Royal Liverpool and Broadgreen University Hospital, Liverpool

NW3 2QG

Royal Free Hospital, London

SE5 9RS

King's College Hospital NHS Foundation Trust, London

W12 OHS

Hammersmith Hospital, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY