A Study of Pharmacokinetic Drug Interaction Study of the Hedgehog Pathway Inhibitor GDC-0449 in Combination With Rosiglitazone or Combined Oral Contraceptive in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists

PHASE1CompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

November 30, 2010

Primary Completion Date

March 31, 2012

Study Completion Date

March 31, 2012

Conditions

Solid Cancers

Interventions

DRUG

Vismodegib

Vismodegib was supplied in hard gelatin capsules.

DRUG

Rosiglitazone

Rosiglitazone was supplied in tablets.

DRUG

Norethindrone/ethinyl estradiol

Norethindrone/ethinyl estradiol was supplied in tablets.

Trial Locations (3)

Detroit

Houston

Stanford