A Study of First-Line Ambrisentan and Tadalafil Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

PHASE3CompletedINTERVENTIONAL
Enrollment

610

Participants

Timeline

Start Date

October 1, 2010

Primary Completion Date

July 31, 2014

Study Completion Date

July 31, 2014

Conditions
Hypertension, Pulmonary
Interventions
DRUG

ambrisentan

ambrisentan (target dose: 10mg)

DRUG

tadalafil

tadalafil (target dose: 40mg)

Trial Locations (143)

1070

GSK Investigational Site, Brussels

1090

GSK Investigational Site, Vienna

2010

GSK Investigational Site, Darlinghurst

2050

GSK Investigational Site, Camperdown

3000

GSK Investigational Site, Leuven

3004

GSK Investigational Site, Melbourne

4032

GSK Investigational Site, Chermside

6000

GSK Investigational Site, Perth

7000

GSK Investigational Site, Hobart

10003

GSK Investigational Site, New York

10019

GSK Investigational Site, New York

10021

GSK Investigational Site, New York

10032

GSK Investigational Site, New York

11040

GSK Investigational Site, New Hyde Park

12559

GSK Investigational Site, Berlin

13915

GSK Investigational Site, Marseille

14004

GSK Investigational Site, Córdoba

14623

GSK Investigational Site, Rochester

15212

GSK Investigational Site, Pittsburgh

15213

GSK Investigational Site, Pittsburgh

15706

GSK Investigational Site, Santiago de Compostela

17475

GSK Investigational Site, Greifswald

19104

GSK Investigational Site, Philadelphia

19140

GSK Investigational Site, Philadelphia

20246

GSK Investigational Site, Hamburg

21201

GSK Investigational Site, Baltimore

22908

GSK Investigational Site, Charlottesville

23298

GSK Investigational Site, Richmond

23507

GSK Investigational Site, Norfolk

27599

GSK Investigational Site, Chapel Hill

28034

GSK Investigational Site, Madrid

28041

GSK Investigational Site, Madrid

28222

GSK Investigational Site, Majadahonda (Madrid)

28803

GSK Investigational Site, Asheville

29010

GSK Investigational Site, Málaga

29200

GSK Investigational Site, Brest

30030

GSK Investigational Site, Decatur

30322

GSK Investigational Site, Atlanta

30625

GSK Investigational Site, Hanover

31059

GSK Investigational Site, Toulouse

32209

GSK Investigational Site, Jacksonville

32610

GSK Investigational Site, Gainesville

32803

GSK Investigational Site, Orlando

33331

GSK Investigational Site, Weston

33604

GSK Investigational Site, Pessac

34295

GSK Investigational Site, Montpellier

34741

GSK Investigational Site, Kissimmee

35294

GSK Investigational Site, Birmingham

35392

GSK Investigational Site, Giessen

36617

GSK Investigational Site, Mobile

37232

GSK Investigational Site, Nashville

38700

GSK Investigational Site, La Tronche

39008

GSK Investigational Site, Santander

40138

GSK Investigational Site, Bologna

41013

GSK Investigational Site, Seville

43221

GSK Investigational Site, Columbus

44195

GSK Investigational Site, Cleveland

45004

GSK Investigational Site, Toledo

45219

GSK Investigational Site, Cincinnati

45267

GSK Investigational Site, Cincinnati

46026

GSK Investigational Site, Valencia

46032

GSK Investigational Site, Carmel

48085

GSK Investigational Site, Troy

48109

GSK Investigational Site, Ann Arbor

48201

GSK Investigational Site, Detroit

50937

GSK Investigational Site, Cologne

52242

GSK Investigational Site, Iowa City

53127

GSK Investigational Site, Bonn

53215

GSK Investigational Site, Milwaukee

54511

GSK Investigational Site, Vandœuvre-lès-Nancy

54636

GSK Investigational Site, Thessaloniki

56124

GSK Investigational Site, Pisa

59037

GSK Investigational Site, Lille

60181

GSK Investigational Site, Oakbrook Terrace

63110

GSK Investigational Site, St Louis

66160

GSK Investigational Site, Kansas City

66421

GSK Investigational Site, Homburg

68100

GSK Investigational Site, Alexandroupoli

68131

GSK Investigational Site, Omaha

69126

GSK Investigational Site, Heidelberg

69677

GSK Investigational Site, Bron

70112

GSK Investigational Site, New Orleans

74245

GSK Investigational Site, Löwenstein

75390

GSK Investigational Site, Dallas

76508

GSK Investigational Site, Temple

77030

GSK Investigational Site, Houston

79106

GSK Investigational Site, Freiburg im Breisgau

80045

GSK Investigational Site, Aurora

81377

GSK Investigational Site, Munich

84157

GSK Investigational Site, Murray

85012

GSK Investigational Site, Phoenix

85724

GSK Investigational Site, Tucson

90073

GSK Investigational Site, Los Angeles

90502

GSK Investigational Site, Torrance

92093

GSK Investigational Site, La Jolla

93053

GSK Investigational Site, Regensburg

94275

GSK Investigational Site, Le Kremlin-Bicêtre

95100

GSK Investigational Site, Catania

95817

GSK Investigational Site, Sacramento

97074

GSK Investigational Site, Würzburg

97220

GSK Investigational Site, Portland

97448

GSK Investigational Site, Saint-Pierre

04102

GSK Investigational Site, Portland

02111

GSK Investigational Site, Boston

02115

GSK Investigational Site, Boston

02118

GSK Investigational Site, Boston

01199

GSK Investigational Site, Springfield

07962

GSK Investigational Site, Morristown

07112

GSK Investigational Site, Newark

02903

GSK Investigational Site, Providence

A-6020

GSK Investigational Site, Innsbruck

T1Y 6J4

GSK Investigational Site, Calgary

V5Z 1M9

GSK Investigational Site, Vancouver

R3A 1R8

GSK Investigational Site, Winnipeg

M5G 2N2

GSK Investigational Site, Toronto

G1V 4G5

GSK Investigational Site, Québec

01307

GSK Investigational Site, Dresden

04103

GSK Investigational Site, Leipzig

124 62

GSK Investigational Site, Athens

176 74

GSK Investigational Site, Athens

00161

GSK Investigational Site, Rome

09134

GSK Investigational Site, Cagliari

812-8582

GSK Investigational Site, Fukuoka

060-8648

GSK Investigational Site, Hokkaido

431-3192

GSK Investigational Site, Shizuoka

113-8655

GSK Investigational Site, Tokyo

1081 HV

GSK Investigational Site, Amsterdam

6229 HX

GSK Investigational Site, Maastricht

3015 CE

GSK Investigational Site, Rotterdam

08035

GSK Investigational Site, Barcelona

08036

GSK Investigational Site, Barcelona

08907

GSK Investigational Site, L'Hospitalet de Llobregat

07010

GSK Investigational Site, Palma de Mallorca

SE-413 45

GSK Investigational Site, Gothenburg

SE-581 85

GSK Investigational Site, Linköping

SE-221 85

GSK Investigational Site, Lund

SE-901 85

GSK Investigational Site, Umeå

SE-751 85

GSK Investigational Site, Uppsala

CB3 8RE

GSK Investigational Site, Cambridge

G81 4DY

GSK Investigational Site, Clydebank

NW3 2QH

GSK Investigational Site, London

SW3 6NP

GSK Investigational Site, London

S10 2JF

GSK Investigational Site, Sheffield

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Gilead Sciences

INDUSTRY

lead

GlaxoSmithKline

INDUSTRY