Antihypertensive Treatment of Acute Cerebral Hemorrhage-II

PHASE3TerminatedINTERVENTIONAL
Enrollment

1,000

Participants

Timeline

Start Date

May 15, 2011

Primary Completion Date

December 21, 2015

Study Completion Date

March 8, 2016

Conditions
Intracerebral Hemorrhage
Interventions
DRUG

Intravenous nicardipine hydrochloride

"IV nicardipine is initiated at a rate of 5 mg/hr, is continued, and is increased by 2.5 mg/hr increments every 15 min until the target SBP or maximum dose of 15 mg/hr is reached. If SBP is above the target SBP despite infusion of the maximum nicardipine dose for 30 minutes, a second agent may be used (Labetalol 5-20 mg IV bolus every 15 min; diltiazem/urapidil in countries without labetalol) for another hour. Nicardipine infusion is decreased incrementally or is stopped if SBP falls below the desired treatment range.~Fluid bolus for SBP still falling below 110 mmHG (millimeters of mercury) with nicardipine off is given to prevent organ hypoperfusion. Vasopressor agents are not used unless symptoms related to or possibly exacerbated by hypoperfusion are present."

Trial Locations (171)

100

National Taiwan University Hospital, Taipei

111

Shin-Kong Wu Ho-Su Memorial Hospital, Taipei

114

Tri-Service General Hospital, Taipei

404

China Medical University Hospital, Taichung

407

Taichung Veterans General Hopital, Taichung

807

Kaohsiung Medical University Hospital, Kaohsiung City

10029

SUNY Downstate, New York

10032

Columbia University, New York

10451

Lincoln Medical and Mental Health Center, New York

11030

North Shore University Hospital, Manhasset

11203

New York City Health and Hospitals Corp. / Kings County Hospital, Brooklyn

11219

Mamoides Medical Center, Brooklyn

12203

Charité Universtity Medicine Berlin, Berlin

13790

UHS Wilson Medical Center, Johnson City

14214

Sister of Charity/Buffalo Mercy Hospital, Catholic Health System, Buffalo

14621

Rochester General Hospital, Rochester

14642

Strong Stroke Center, Rochester

15213

UPMC Presbyterian Hospital, Pittsburgh

15219

UPMC-Mercy Hospital, Pittsburgh

17033

Penn State Univ/ Hershey Med Center, Hershey

17403

Wellspan York Hospital, York

17822

Geisinger Medical Center, Danville

18103

Lehigh Valley Health Network, Allentown

19001

Abington Memorial Hospital, Abington

19102

Hahnemann University Hospital, Philadelphia

19104

University of Pennsylvania, Philadelphia

19107

Thomas Jefferson University, Philadelphia

19140

Temple University, Philadelphia

19611

Reading Hospital, West Reading

19718

Christiana Hospital, Newark

26506

West Virginia University - Ruby Memorial Hospital, Morgantown

27103

Novant Clinical Research Institute/Forsyth Medical Center, Winston-Salem

27157

Wake Forest Baptist Medical Center (Wake Forest School of Medicine), Winston-Salem

27405

Guilford Neurologic Associates, Greenboro

27834

Vidant Medical Center, Greenville

29203

Palmetto Health, Columbia

30303

Grady Memorial Hospital, Atlanta

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital, Atlanta

32207

Baptist Medical Center Jacksonville, Jacksonville

32224

Mayo Clinic - Jacksonville, Jacksonville

32611

University of Florida Gainesville, Gainesville

33612

University of South Florida, Tampa General Hospital, Tampa

35249

UAB Comprehensive Stroke Center, Birmingham

37232

Vanderbilt Stroke Center, Nashville

39216

University of Mississippi Medical Center, Jackson

40292

University of Louisville, Louisville

43210

Ohio State University - Wexner Medical Center, Columbus

43614

University of Toledo Medical Center, Toledo

44106

University Hospitals Case Medical Center, Cleveland

44307

Akron General Hospital, Akron

46804

Lutheran Hospital Indiana, Fort Wayne

46805

Parkview Hospital, Fort Wayne

48073

William Beaumont Hospital, Royal Oak

48129

University Hospital Meunster, Münster

48201

Wayne State University - Detroit Receiving Hospital, Detroit

48202

Henry Ford Health System, Detroit

48235

Sinai-Grace Hospital, Detroit

49201

Allegiance Health, Jackson

53105

University of Bonn, Bonn

53215

Aurora St. Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwakee

55101

Regions Hospital, Saint Paul

55404

Hennepin County Medical Center, Minneapolis

55435

Fairview Southdale Hospital, Edina

55805

Essentia Health St. Mary's Medical Center, Duluth

56303

St. Cloud Hospital, Saint Cloud

60153

Loyola University Medical Center, Maywood

60453

Advocate Christ Medical Center, Oak Lawn

61637

OSF Saint Francis Medical Center, Peoria

63104

Saint Louis University, St Louis

64111

Saint Luke's Neuroscience Institute, Kansas City

64132

Research Medical Center, Kansas City

65929

Clinic Frankfurt Hoechst, Frankfurt

66160

Kansas University Medical Center, Kansas City

68167

University Hospital Mannheim, Mannheim

69120

University Hospital Heidelberg, Heidelberg

70072

West Jefferson Medical Center, Marrero

70112

Interim LSU Hospital, New Orleans

Tulane Medical Center, New Orleans

70121

Ochsner Clinic Foundation, New Orleans

71103

Louisiana State University Health Sciences Center, Shreveport, Shreveport

72076

University of Tubingen, Tübingen

73104

Oklahoma University Health Sciences Center (OUHSC), Oklahoma City

75235

UT Southwestern - Parkland Hospital, Dallas

77024

Memorial Herman - Texas Medical Center, Houston

77030

Baylor College of Medicine - Ben Taub Community Hospital, Houston

Baylor College of Medicine - St. Luke's Episcopal Hospital, Houston

Methodist Hospital - The Neurological Institute, Houston

78229

University of Texas Health Science Center at San Antonio, San Antonio

78550

Valley Baptist Medical Center, Harlingen

78705

Seton Medical Center Austin, Austin

St. David's Medical Center, Austin

University Medical Center Brackenridge, Austin

79430

Texas Tech University Health Sciences Center, El Paso

80113

Colorado Neurological Institute, Englewood

83404

Eastern Idaho Medical Consultants, Idaho Falls

84107

Intermountain Medical Center, Murray

85008

Maricopa Medical Center, Phoenix

85259

Mayo Clinic Pheonix, Scottsdale

85713

Banner University Medical Center - South Campus, Tuscon

85724

Banner University Medical Center - University Campus, Tuscon

87131

University of New Mexico, Albuquerque

90806

Long Beach Memorial Medical Center, Long Beach

92093

University of California San Diego, La Jolla

92658

Hoag Memorial Hospital Presbyterian, Newport Beach

93721

Community Regional Medical Center of Fresno, Fresno

94143

UCSF Medical Center, San Francisco

94304

Stanford University, Palo Alto

95124

Good Samaritan Hospital, San Jose

95138

Santa Clara Valley Medical Center, Santa Clara

95661

Sutter Roseville Medical Center, Roseville

95817

UC Davis Medical Center, Sacramento

97225

Providence Brain and Spine Institute, Portland

100050

Beijing Tiantan Hospital, Beijing

100191

Peking University Third Hospital, Beijing

300140

Tianjin Fourth Central Hospital, Tianjin

318020

The First People's Hospital of Taizhou, Taizhou

430019

Wuhan Brain Hospital, Wuhan

430060

Renmin Hospital of Wuhan University, Wuhan

450003

People's Hopital of Zhengzhou, Zhengzhou

90095-9574

Ronald Regan UCLA Medical Center, Los Angeles

06510

Yale - New Haven Hospital, New Haven

62794-9643

Southern Illinois University Memorial Medical Center, Springfield

40536-0296

University of Kentucky, Lexington

04106

Maine Medical Center, South Portland

02114

Massachusetts General Hospital, Boston

02115

Brigham & Women's Hospital, Boston

02118

Boston Medical Center, Boston

08103

Cooper University Hospital, Camden

07012

St. Joseph's Regional Medical Center, Clifton

08818

New Jersey Neuroscience Institute, JFK Medical Center, Edison

07601

Hackensack University Medical Center, Hackensack

28801-4601

Mission Hospital, Asheville

02903

Rhode Island Hospital, Providence

23298-0631

Virginia Commonwealth University Medical Center, Richmond

2E3.27WMC

University of Alberta, Edmonton

H3A 2B4

Montreal Neurological Institute and Hospital, Montreal

050000

The Second Hospital of Hebei Medical University, Shijiazhuang

030001

The Second Hospital of Shanxi Medical University, Taiyuan

The First Hospital of Shanxi Medical University, Taiyuan

Unknown

Baotou Central Hospital, Baotou

Datong Third People's Hospital, Datong

Kobe City Medical Center General Hospital, Kobe

Kohnan Hospital, Sendai

Kyorin University, Tokyo

Seoul National University Bundang Hospital, Seongnam-si

Changhua Christian Hospital, Changhua

Kaohsiung Veterans General Hospital, Kaohsiung City

National Cheng Kung University Hospital, Tainan City

Taipei Veteran's Hospital, Taipei

01307

University Hospital Dresden, Dresden

06120

University Hospital Halle, Halle

04103

University Hospital Leipzig, Leipzig

460-0001

Nagoya Medical Center, Nagoya

060-8570

Nakamura Memorial Hospital, Sapporo

230-8765

Saiseikai Yokohamashi Tobu Hospital, Kanagawa

861-4193

Saiseikai Kumamoto Hospital, Kumamoto

810-8563

Kyushu Medical Center, Fukuoka

501-1194

Gifu University Hospital, Gifu

211-0063

St. Marianna - Toyoko, Kawasaki

216-8511

St. Marianna University Hospital, Kawasaki

701-0192

Kawasaki Medical School, Okayama

565-8565

National Cerebral and Cardiovascular Center, Osaka

105-8470

Toranomon Hospital, Tokyo

108-0073

Saiseikai Central Hospital - Tokyo, Tokyo

160-8582

Keio University Hospital, Tokyo

501-757

Chonnam National University Hospital, Gwangju

110-744

Seoul National University Hospital, Seoul

130-702

Kyung Hee University Hospital, Seoul

156-707

Seoul National University Boramae Hospital, Seoul

All Listed Sponsors
collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

collaborator

Medical University of South Carolina

OTHER

collaborator

Johns Hopkins University

OTHER

collaborator

University of Michigan

OTHER

collaborator

Neurocritical Care Research Network

UNKNOWN

collaborator

National Cerebral and Cardiovascular Center, Japan

OTHER

collaborator

Japan Cardiovascular Research Foundation

OTHER

collaborator

Beijing Tiantan Hospital

OTHER

collaborator

China Medical University Hospital

OTHER

collaborator

University Hospital Heidelberg

OTHER

collaborator

Seoul National University Hospital

OTHER

lead

University of Minnesota

OTHER