1,000
Participants
Start Date
May 15, 2011
Primary Completion Date
December 21, 2015
Study Completion Date
March 8, 2016
Intravenous nicardipine hydrochloride
"IV nicardipine is initiated at a rate of 5 mg/hr, is continued, and is increased by 2.5 mg/hr increments every 15 min until the target SBP or maximum dose of 15 mg/hr is reached. If SBP is above the target SBP despite infusion of the maximum nicardipine dose for 30 minutes, a second agent may be used (Labetalol 5-20 mg IV bolus every 15 min; diltiazem/urapidil in countries without labetalol) for another hour. Nicardipine infusion is decreased incrementally or is stopped if SBP falls below the desired treatment range.~Fluid bolus for SBP still falling below 110 mmHG (millimeters of mercury) with nicardipine off is given to prevent organ hypoperfusion. Vasopressor agents are not used unless symptoms related to or possibly exacerbated by hypoperfusion are present."
National Taiwan University Hospital, Taipei
Shin-Kong Wu Ho-Su Memorial Hospital, Taipei
Tri-Service General Hospital, Taipei
China Medical University Hospital, Taichung
Taichung Veterans General Hopital, Taichung
Kaohsiung Medical University Hospital, Kaohsiung City
SUNY Downstate, New York
Columbia University, New York
Lincoln Medical and Mental Health Center, New York
North Shore University Hospital, Manhasset
New York City Health and Hospitals Corp. / Kings County Hospital, Brooklyn
Mamoides Medical Center, Brooklyn
Charité Universtity Medicine Berlin, Berlin
UHS Wilson Medical Center, Johnson City
Sister of Charity/Buffalo Mercy Hospital, Catholic Health System, Buffalo
Rochester General Hospital, Rochester
Strong Stroke Center, Rochester
UPMC Presbyterian Hospital, Pittsburgh
UPMC-Mercy Hospital, Pittsburgh
Penn State Univ/ Hershey Med Center, Hershey
Wellspan York Hospital, York
Geisinger Medical Center, Danville
Lehigh Valley Health Network, Allentown
Abington Memorial Hospital, Abington
Hahnemann University Hospital, Philadelphia
University of Pennsylvania, Philadelphia
Thomas Jefferson University, Philadelphia
Temple University, Philadelphia
Reading Hospital, West Reading
Christiana Hospital, Newark
West Virginia University - Ruby Memorial Hospital, Morgantown
Novant Clinical Research Institute/Forsyth Medical Center, Winston-Salem
Wake Forest Baptist Medical Center (Wake Forest School of Medicine), Winston-Salem
Guilford Neurologic Associates, Greenboro
Vidant Medical Center, Greenville
Palmetto Health, Columbia
Grady Memorial Hospital, Atlanta
Emory University Hospital Midtown, Atlanta
Emory University Hospital, Atlanta
Baptist Medical Center Jacksonville, Jacksonville
Mayo Clinic - Jacksonville, Jacksonville
University of Florida Gainesville, Gainesville
University of South Florida, Tampa General Hospital, Tampa
UAB Comprehensive Stroke Center, Birmingham
Vanderbilt Stroke Center, Nashville
University of Mississippi Medical Center, Jackson
University of Louisville, Louisville
Ohio State University - Wexner Medical Center, Columbus
University of Toledo Medical Center, Toledo
University Hospitals Case Medical Center, Cleveland
Akron General Hospital, Akron
Lutheran Hospital Indiana, Fort Wayne
Parkview Hospital, Fort Wayne
William Beaumont Hospital, Royal Oak
University Hospital Meunster, Münster
Wayne State University - Detroit Receiving Hospital, Detroit
Henry Ford Health System, Detroit
Sinai-Grace Hospital, Detroit
Allegiance Health, Jackson
University of Bonn, Bonn
Aurora St. Luke's Medical Center, Milwaukee
Medical College of Wisconsin, Milwakee
Regions Hospital, Saint Paul
Hennepin County Medical Center, Minneapolis
Fairview Southdale Hospital, Edina
Essentia Health St. Mary's Medical Center, Duluth
St. Cloud Hospital, Saint Cloud
Loyola University Medical Center, Maywood
Advocate Christ Medical Center, Oak Lawn
OSF Saint Francis Medical Center, Peoria
Saint Louis University, St Louis
Saint Luke's Neuroscience Institute, Kansas City
Research Medical Center, Kansas City
Clinic Frankfurt Hoechst, Frankfurt
Kansas University Medical Center, Kansas City
University Hospital Mannheim, Mannheim
University Hospital Heidelberg, Heidelberg
West Jefferson Medical Center, Marrero
Interim LSU Hospital, New Orleans
Tulane Medical Center, New Orleans
Ochsner Clinic Foundation, New Orleans
Louisiana State University Health Sciences Center, Shreveport, Shreveport
University of Tubingen, Tübingen
Oklahoma University Health Sciences Center (OUHSC), Oklahoma City
UT Southwestern - Parkland Hospital, Dallas
Memorial Herman - Texas Medical Center, Houston
Baylor College of Medicine - Ben Taub Community Hospital, Houston
Baylor College of Medicine - St. Luke's Episcopal Hospital, Houston
Methodist Hospital - The Neurological Institute, Houston
University of Texas Health Science Center at San Antonio, San Antonio
Valley Baptist Medical Center, Harlingen
Seton Medical Center Austin, Austin
St. David's Medical Center, Austin
University Medical Center Brackenridge, Austin
Texas Tech University Health Sciences Center, El Paso
Colorado Neurological Institute, Englewood
Eastern Idaho Medical Consultants, Idaho Falls
Intermountain Medical Center, Murray
Maricopa Medical Center, Phoenix
Mayo Clinic Pheonix, Scottsdale
Banner University Medical Center - South Campus, Tuscon
Banner University Medical Center - University Campus, Tuscon
University of New Mexico, Albuquerque
Long Beach Memorial Medical Center, Long Beach
University of California San Diego, La Jolla
Hoag Memorial Hospital Presbyterian, Newport Beach
Community Regional Medical Center of Fresno, Fresno
UCSF Medical Center, San Francisco
Stanford University, Palo Alto
Good Samaritan Hospital, San Jose
Santa Clara Valley Medical Center, Santa Clara
Sutter Roseville Medical Center, Roseville
UC Davis Medical Center, Sacramento
Providence Brain and Spine Institute, Portland
Beijing Tiantan Hospital, Beijing
Peking University Third Hospital, Beijing
Tianjin Fourth Central Hospital, Tianjin
The First People's Hospital of Taizhou, Taizhou
Wuhan Brain Hospital, Wuhan
Renmin Hospital of Wuhan University, Wuhan
People's Hopital of Zhengzhou, Zhengzhou
Ronald Regan UCLA Medical Center, Los Angeles
Yale - New Haven Hospital, New Haven
Southern Illinois University Memorial Medical Center, Springfield
University of Kentucky, Lexington
Maine Medical Center, South Portland
Massachusetts General Hospital, Boston
Brigham & Women's Hospital, Boston
Boston Medical Center, Boston
Cooper University Hospital, Camden
St. Joseph's Regional Medical Center, Clifton
New Jersey Neuroscience Institute, JFK Medical Center, Edison
Hackensack University Medical Center, Hackensack
Mission Hospital, Asheville
Rhode Island Hospital, Providence
Virginia Commonwealth University Medical Center, Richmond
University of Alberta, Edmonton
Montreal Neurological Institute and Hospital, Montreal
The Second Hospital of Hebei Medical University, Shijiazhuang
The Second Hospital of Shanxi Medical University, Taiyuan
The First Hospital of Shanxi Medical University, Taiyuan
Baotou Central Hospital, Baotou
Datong Third People's Hospital, Datong
Kobe City Medical Center General Hospital, Kobe
Kohnan Hospital, Sendai
Kyorin University, Tokyo
Seoul National University Bundang Hospital, Seongnam-si
Changhua Christian Hospital, Changhua
Kaohsiung Veterans General Hospital, Kaohsiung City
National Cheng Kung University Hospital, Tainan City
Taipei Veteran's Hospital, Taipei
University Hospital Dresden, Dresden
University Hospital Halle, Halle
University Hospital Leipzig, Leipzig
Nagoya Medical Center, Nagoya
Nakamura Memorial Hospital, Sapporo
Saiseikai Yokohamashi Tobu Hospital, Kanagawa
Saiseikai Kumamoto Hospital, Kumamoto
Kyushu Medical Center, Fukuoka
Gifu University Hospital, Gifu
St. Marianna - Toyoko, Kawasaki
St. Marianna University Hospital, Kawasaki
Kawasaki Medical School, Okayama
National Cerebral and Cardiovascular Center, Osaka
Toranomon Hospital, Tokyo
Saiseikai Central Hospital - Tokyo, Tokyo
Keio University Hospital, Tokyo
Chonnam National University Hospital, Gwangju
Seoul National University Hospital, Seoul
Kyung Hee University Hospital, Seoul
Seoul National University Boramae Hospital, Seoul
Collaborators (1)
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Medical University of South Carolina
OTHER
Johns Hopkins University
OTHER
University of Michigan
OTHER
Neurocritical Care Research Network
UNKNOWN
National Cerebral and Cardiovascular Center, Japan
OTHER
Japan Cardiovascular Research Foundation
OTHER
Beijing Tiantan Hospital
OTHER
China Medical University Hospital
OTHER
University Hospital Heidelberg
OTHER
Seoul National University Hospital
OTHER
University of Minnesota
OTHER