Predictors of Response to Augmentation With Ziprasidone (Geodon®) in Major Depressive Disorder

PHASE4CompletedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

February 28, 2010

Primary Completion Date

December 31, 2011

Study Completion Date

December 31, 2011

Conditions
DepressionBipolar Disorder
Interventions
DRUG

ziprasidone

Ziprasidone will be administered as a pill. The once-daily total daily dose will be 80-160 mg/d of ziprasidone. Dosing will begin at 20 mg BID with an escalation strategy based on target symptoms and tolerability, with a target dose range of 80-160 mg/d. Dose escalations will occur by increments of 20-40 mg weekly.

DRUG

Sugar pill

The once-daily total daily dose will be 80-160 mg/d of the sugar pill. Dosing will begin at 20 mg BID with an escalation strategy based on target symptoms and tolerability, with a target dose range of 80-160 mg/d. Dose escalations will occur by increments of 20-40 mg weekly.

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Duke University

OTHER

collaborator

University of South Carolina

OTHER

lead

Tufts Medical Center

OTHER