Effects of Tofacitinib (CP-690,550) on Magnetic Resonance Imaging (MRI)- Assessed Joint Structure In Early Rheumatoid Arthritis (RA)

PHASE2CompletedINTERVENTIONAL
Enrollment

109

Participants

Timeline

Start Date

October 31, 2010

Primary Completion Date

November 30, 2013

Study Completion Date

November 30, 2013

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Tasocitinib plus Methotrexate

Tofacitinib (CP 690,550) 10 mg BID, tablets + methotrexate (MTX) 10 mg/wk to 20 mg/wk, titrated over 2 months

DRUG

Tofacitinib plus placebo methotrexate

Tofacitinib (CP-90,550) 10 mg BID, tablets. Placebo to match methotrexate (MTX) capsules titrated as in Treatment Arm 1.

DRUG

Placebo tofacitinib plus Methotrexate

Methotrexate (MTX) 10 mg/wk to 20 mg/wk, capsules, titrated over 2 months. Placebo in tablets to match tofacitinib

Trial Locations (40)

1023

Orszagos Reumatologiai es Fizioterapias Intezet, Budapest

1036

Synexus Magyarorszag Kft., Budapest

4032

Debreceni Egyetem Orvos- es Egeszsegtudomanyi Centrum, Reumatologiai Tanszek, Debrecen

8230

Drug Research Center Kft., Balatonfüred

9027

Petz Aladar Megyei Oktato Korhaz/Reumatologiai es Mozgasszervi Rehabilitacios Centrum, Győr

10000

General Hospital Sveti Duh, Zagreb

11850

Centro de Investigacion y Tratamiento Reumatologico S.C., México

Hospital Angeles Mocel, México

Centro de Investigacion y Tratamiento Reumatologico SC, Mexico City

Hospital Angeles Mocel, Mexico City

Hospital Angeles Mocel, Chapultepec

21000

University Hospital Centre Split,Department for Internal Medicine, Division of Clinical Rheumatology, Split

31000

Investigacion y Biomedicina de Chihuahua S.C, Chihuahua City

32174

Millennium Research, Ormond Beach

33710

St. Petersburg Arthritis Center, St. Petersburg

33782

DMI Research, Inc., Pinellas Park

75013

Office of John P. Lavery, MD, PA, Allen

78200

Centro de Alta Especialidad en Reumatologia e Investigacion del Potosi S.C., San Luis Potosí City

85234

ArthroCare, Arthritis Care & Research, PC, Gilbert

91786

Inland Rheumatology Clinical Trials, Inc., Upland

92646

Talbert Medical Group, Huntington Beach

5090145

Hospital Base Valdivia, Valdivia

5311089

Consulta Privada Dr. Juan Ignacio Vargas, Osorno

73104 5005

Oklahoma Medical Research Foundation, Oklahoma City

C1015ABO

OMI - Organización Médica de Investigación, Buenos Aires

C1034ACO

Saint Dennis Medical Group S.A., Buenos Aires

C1428DZF

Consultorios Reumatologicos Pampa, Buenos Aires

253 01

ARTMEDI UPD s r.o., Hostivice

110 00

Nemocnice na Frantisku s poliklinikou, Prague

Nemocnice na Frantisku, Prague

128 50

Revmatologicky ustav, Prague

148 00

DC Mediscan, Praha 11 - Chodov

686 68

Uherskohradistska nemocnice, a.s., Uherské Hradiště

760 01

Nemocnice Atlas, a.s., Zlín

PV-Medical s.r.o., Zlín

15-879

Niepubliczny Zaklad Opieki Zdrowotnej Centrum Osteoporozy i Chorob Kostno-Stawowych J., Bialystok

61-397

Prywatna Praktyka Lekarska Prof. UM dr hab. med. Pawel Hrycaj, Poznan

87-100

"Nzoz Nasz Lekarz", Torun

00918

Mindful Medical Research, San Juan

San Juan Arthritis & Research Center, San Juan

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY