A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung

PHASE3CompletedINTERVENTIONAL
Enrollment

343

Participants

Timeline

Start Date

January 13, 2011

Primary Completion Date

November 30, 2013

Study Completion Date

November 30, 2016

Conditions
Non Squamous Lung Cancer
Interventions
DRUG

treatment

crizotinib 250mg orally continuous twice daily dosing

DRUG

treatment

pemetrexed 500mg/m2 IV day 1 plus cisplatin 75mg/m2 IV day 1 every 21 days OR pemetrexed 500mg/m2 IV day 1 plus carboplatin AUC 5 or 6 day 1 every 21 days investigator's choice

Trial Locations (249)

27

Clinica Anglo Americana/Centro de Investigacion Oncologia CAA, San Isidro

404

China Medical University Hospital, Taichung

833

Chang Gung Medical Foundation, Kaohsiung Branch, Kaohsiung City

1000

Institut Jules Bordet, Centre des Tumeurs de l'ULB, Brussels

1090

Universitair Ziekenhuis Brussel / Medische Oncologie, Brussels

1200

Cliniques Universitaires St Luc, Brussels

1210

Centre Hospitalier de Luxembourg, Luxembourg

2050

Chris O'Brien Lifehouse, Camperdown

2065

Royal North Shore Hospital, St Leonards

2193

University of Witwatersrand Oncology, Johannesburg

2560

Macarthur Cancer Therapy Centre, Campbelltown

2650

UZ Antwerpen-Pneumologie, Edegem

3002

Peter MacCallum Cancer Centre, Department of Haematology and Medical Oncology, East Melbourne

3199

Peninsula & South Eastern Haematology and Oncology Group, Frankston

4000

Centre Hospitalier Universitaire de Liege, Liège

4006

The Royal Brisbane & Womens Hospital, Herston

4032

The Prince Charles Hospital, Chermside

4600

Klinikum Wels-Grieskirchen, Wels

4812

Parkhaven Medical Center, Hyde Park

4814

The Townsville Hospital, Douglas

5000

Department of Medical Oncology, Adelaide

6000

Grand Hopital de Charleroi -Site Notre Dame, Charleroi

Luzerner Kantonsspital (LUKS), Lucerne

7700

Rondebosch Oncology Centre, Rondebosch Medical Centre, Cape Town

8800

Department of Pulmonary Diseases AZ Delta, Roeselare

9000

Universitair Ziekenhuis Gent (U.Z. Gent), Ghent

10043

Azienda Ospedaliera Universitaria San Luigi Gonzaga, Orbassano (TO)

S.C. Farmacia Ospedaliera , Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano (TO)

10117

Charite - Universitaetsmedizin Berlin, Campus Mitte, Berlin

11030

North Shore University Hospital, Manhasset

11040

Long Island Jewish Medical Center, New Hyde Park

11042

NSLIJ Health System/Monter Cancer Center, Lake Success

13210

SUNY Upstate Medical University, Syracuse

13915

APHM - Hopital Nord / Service d'Oncologie Multidisciplinaire et Innovations Thérapeutiques, Marseille

14033

CHU de Caen, Caen

14080

Instituto Nacional de Cancerologia, México

19111

Fox Chase Cancer Center, Philadelphia

20007

Georgetown University Hospital, Washington D.C.

Research Pharmacy, Georgetown University Medical Center, Washington D.C.

20133

Fondazione IRCCS Istituto Nazionale Tumori, Struttura Complessa di Medicina Oncologica 1, Milan

20141

Farmacia Istituto Europeo di Oncologia IRCCS, U.O. Farmacia, Milan

Istituto Europeo di Oncologia, Milan

20162

Ospedale Niguarda Ca'Granda, Divisione Oncologia Medica Falck, Milan

26121

Pius-Hospital Oldenburg, Oldenburg

28034

Hospital Ramon Y Cajal, Madrid

28041

Hospital Doce de Octubre, Madrid

28500

Satakunnan keskussairaala/Keuhkosairauksien osasto A4, Pori

29010

Hospital Universitario Virgen de La Victoria, Málaga

30033

Georgia Cancer Specialists, Decatur

30060

Georgia Cancer Specialists, Marietta

30341

Georgia Cancer Specialists, Atlanta

30342

Georgia Cancer Specialists, Sandy Springs

30606

Georgia Cancer Specialists, Athens

31217

Georgia Cancer Specialists, Macon

32803

Florida Hospital, Orlando

32804

Cancer Institute of Florida, Orlando

Investigational Drug Services, Orlando

33081

Struttura Operativa Complessa Oncologia Medica A Centro di Riferimento Oncologico, Aviano

Farmacia, Aviano (PN)

33305

Chang Gung Medical Foundation, LinKou Branch, Taoyuan District

33486

Lynn Cancer Institute Center for Hematology Oncology, Boca Raton

33520

Tampereen yliopistollinen sairaala, Tampere

34295

Hopital Arnaud de Villeneuve / CHU de Montpellier, Montpellier

35016

Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria

37055

Tennessee Oncology, PLLC, Dickson

37066

Tennessee Oncology, PLLC, Gallatin

37067

Tennessee Oncology, PLLC, Franklin

37076

Tennessee Oncology, PLLC, Hermitage

37087

Tennessee Oncology, PLLC, Lebanon

37130

Tennessee Oncology, PLLC, Murfreesboro

37167

Tennessee Oncology, PLLC, Smyrna

37203

Sarah Cannon Research Institute, Nashville

Tennessee Oncology, PLLC, Nashville

37205

Tennessee Oncology, PLLC, Nashville

37207

Tennessee Oncology, PLLC, Nashville

37211

Tennessee Oncology, PLLC, Nashville

38043

CHU Grenoble, Grenoble

40100

Unità Operativa di Oncologia Medica Azienda USL Città di Bologna, Bologna

40705

Taichung Veterans General Hospital, Comprehensive Cancer Center, Taichung

41009

Hospital Universitario Virgen Macarena, Seville

41063

Kliniken Maria Hilf GmbH, Mönchengladbach

42123

IRCCS -Arcispedale S. Maria Nuova Tecnologie Avanzate e Modelli Assistenziali in Oncologia, Reggio Emilia

43126

Oncologia Medica, Azienda Ospedaliero- Universitaria di Parma, Parma

46202

Indiana University Hospital, Indianapolis

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

Lois and Eskenazi Hospital, Indianapolis

46321

Monroe Medical Association, Munster

The Community Hospital, Munster

48025

Kresge Eye Institute, Bingham Farms

48201

Karmanos Cancer Institute, Detroit

Kresge Eye Institute, Detroit

48334

Karmanos Cancer Institute at Farmington Hills, Farmington Hills

49102

City Multiple-Discipline Clinical Hospital #4,, Dnipropetrovsk

City Multiple-Discipline Clinical Hospital #4, Dnipropetrovsk

"Department of Oncology and Medical Radiology, SI DMA of MOH, Ukraine", Dnipropetrovsk

50009

Hospital Clinico Universitario Lozano Blesa, Zaragoza

55131

UNIVERSITÄTSMEDIZIN der Johannes Gutenberg-Universität Mainz, Mainz

57124

Ospedale Civile Azienda USL Toscana Nord Ovest, Livorno

Unità Operativa Farmacia Ospedaliera PO di Livorno, Livorno

59020

Centre Oscar Lambret, Lille

60426

Al Fisher, Pharm D., Harvey

Ingalls Memorial Hospital, Harvey

Monroe Medical Associates, Harvey

60477

Monroe Medical Associates, Tinley Park

60637

University of Chicago, Chicago

63110

Washington University Center for Advanced Medicine Infusion Center Pharmacy, St Louis

63141

Siteman Cancer Center - West County, Creve Coeur

63376

Siteman Cancer Center, City of Saint Peters

65199

HSK Dr.- Horst-Schmidt-Kliniken GmbH,, Wiesbaden

67091

Nouvel Hopital Civil - HSU - Pôle de Pathologie Thoracique - Service de Pneumologie, Strasbourg

69126

Thoraxklinik am Universitaetsklinikum Heidelberg, Heidelberg

69373

Centre Leon Berard, Lyon

70121

Ochsner Clinic Foundation, New Orleans

70124

Istituto dei tumori Giovanni Paolo II, Bari

75390

UT Southwestern Medical Center, Dallas

UT Southwestern University Hospital - William P. Clements, Jr., Dallas

UT Southwestern University Hospital - Zale Lipshy, Dallas

75970

Hopital Tenon, Service de Pneumologie, Paris

76137

St.Vincentius-Kliniken Karlsruhe, Karlsruhe

77030

University of Texas MD Anderson Cancer Center, Houston

79031

Lviv State Oncologic Regional Treatment and Diagnostic Center, Lviv

80131

A.O.R.N. Ospedale Dei Colli - Monaldi, Napoli

Farmacia, Napoli

87106

University of New Mexico Cancer Center, Albuquerque

UNM Eye Clinic, Albuquerque

88011

Memorial Medical Center, Las Cruces

88100

"Azienda Ospedaliero-Universitaria Mater Domini", Catanzaro

Unità Operativa di Farmacia - Campus Salvatore venuta, Catanzaro

90027

CCTAP, Los Angeles

92108

Kaiser Permanente Southern California, San Diego

92120

CCTAP, San Diego

92335

CCTAP, Fontana

92350

Loma Linda University Cancer Center, Loma Linda

92354

Loma Linda University Cancer Center (LLUCC)-Schuman Pavilion, Loma Linda

Loma Linda University Medical Center, Loma Linda

93009

Hopital Avicenne, Bobigny

97006

OHSU Knight Cancer Institute, Beaverton

97030

OHSU Knight Cancer Institute, Gresham

97062

OHSU Knight Cancer Institute, Tualatin

97210

OHSU Knight Cancer Institute, Portland

97216

OHSU Knight Cancer Institute, Portland

97239

Oregon Health and Science University, Portland

98109

Seattle Cancer Care Alliance, Seattle

98195

University of Washington Medical Center, Seattle

99437

Zentralklinik Bad Berka GmbH, Bad Berka

100021

Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing

100071

307 Hospital of PLA, Beijing

115478

Russian Oncological Research Center N.N. Blokhin, Moscow

119074

National University Hospital, Singapore

169610

National Cancer Centre, Singapore

197022

City Clinical Oncology Dispensary, Saint Petersburg

First Saint-Petersburg State Medical University n.a. I.P. Pavlov, Saint Petersburg

197101

First Saint-Petersburg State Medical University n.a. I.P., Saint Petersburg

197758

Russian Scientific Center of Radiology and Surgical Technologies, Saint Petersburg

198255

City Clinical Oncology Dispensary, Saint Petersburg

200030

Shanghai Chest Hospital/Department of Pulmonary Medicine, Shanghai

Zhongshan Hospital Fudan University, Shanghai

200433

Shanghai Pulmonary Hospital/Dept. of Oncology, Shanghai

210002

No.81 Hospital of the PLA, Nanjing

228510

Parkway Cancer Centre, Singapore

258499

OncoCare Cancer Centre, Singapore

400012

Tata Memorial Centre, Tata Memorial Hospital,, Mumbai

430023

Union Hospital, Tongji Medical College of Huazhong University of Science & Technology/Cancer Center, Wuhan

443031

Samara Regional Clinical Oncology Dispensary, Samara

510080

Oncology Center, Guangdong General Hospital, Guangzhou

610041

Oncology Department, West China Hospital of Sichuan University, Chengdu

4810469

Instituto Clinico Oncologico del Sur, Temuco

8380455

Instituto Nacional del Cancer, Santiago

8380456

Hospital Clinico Universidad de Chile, Seccion de Oncologia, Independencia

90211-1850

Tower Cancer Research Foundation, Beverly Hills

Tower Hematology Oncology Medical Group, Beverly Hills

04005

Maine Center for Cancer Medicine, Biddeford

04011

Maine Center for Cancer Medicine, Brunswick

04073

Maine Center for Cancer Medicine, Sanford

04074

Maine Center for Cancer Medicine, Scarborough

63110-1094

Barnes-Jewish Hospital, St Louis

03756-0001

Dartmouth Hitchcock Medical Center, Lebanon

07962

Hematology-Oncology Associates of Northern New Jersey, Morristown

02914

Vincent Armenio, East Providence

02915

Pharma Resource, East Providence

37232-5536

Henry-Joyce Cancer Clinic, Nashville

37232-7610

Vanderbilt Oncology Pharmacy, Nashville

75390-9015

UT Southwestern Medical Center - Simmons Cancer Center Pharmacy, Dallas

53792-5666

University of Wisconsin Hospital and Clinics, Madison

20231 -050

Instituto Nacional de Cancer - INCA, Rio de Janeiro

98700-000

Associacao Hospital de Caridade de Ijui, Ijuí

90610-000

Hospital Sao Lucas da PUCRS, Porto Alegre

14784-400

Fundacao Pio XII Hospital de Cancer de Barretos, Barretos

01246-000

Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira - ICESP, São Paulo

T6G 1Z2

Cross Cancer Institute, Edmonton

B2H 2Y9

QEII Health Sciences Centre, Halifax

B3H 1V7

QEII Health Sciences Centre, Halifax

L1G 2B9

R.S. McLaughlin Durham Regional Cancer Centre, Oshawa

H3T 1E2

Jewish General Hospital, Montreal

H4A 3J1

McGill University Health Centre (MUHC), Glen Site, Cedars Cancer Centre, Montreal

G1V 4G5

Institut universitaire de cardiologie et de pneumologie de Quebec (IUCPQ), Ste-Foy

00290

Helsingin yliopistollinen keskussairaala, Meilahden kolmiosairaala,Keuhkosairauksien poliklinikka, Helsinki

Unknown

Prince of Wales Hospital, Shatin

Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon

380 016

The Gujarat Cancer & Research Institute (M.P Shah Cancer Hospital),, Ahmedabad

Dublin 8

Aseptic Compounding Unit, Dublin

Department of Medical Oncology, Dublin

06132

Farmacia Ospedaliera, Perugia

SC Oncologia Medica, Ospedale Santa Maria della Misericordia, Perugia

00144

Istituto Regina Elena, Struttura Complessa Oncologia Medica A, Roma

00152

Azienda Ospedaliera San Camillo Forlanini-Padiglione Flaiani, Roma

Farmacia Interna, Roma

00168

Unita Operativa, Oncologia Medica, Istituto di Medicina Interna e Geriatria, Roma

464-8681

Aichi cancer center central hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

003-0804

National Hospital Organization Hokkaido Cancer Center, Sapporo

673-8558

Hyogo Cancer Center, Akashi

236-0051

Kanagawa Cardiovascular and Respiratory Center, Yokohama

980-8574

Tohoku University Hospital, Sendai

700-8558

Okayama University Hospital, Okayama

589-8511

Kinki University Hospital, Osakasayama-shi

411-8777

Shizuoka Cancer Center, Sunto-gun

104-0045

National Cancer Center Hospital, Chuo-Ku

135-8550

The Cancer Institute Hospital of JFCR, Koto-ku

755-0241

National Hospital Organization Yamaguchi-Ube Medical Center, Ube-shi

811-1395

National Hospital organization Kyushu Cancer Center, Fukuoka

812-8582

Kyushu University Hospital Respiratory Medicine, Fukuoka

5223 GZ

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

1081 HV

VUMC, Amsterdam

6229 HX

Academisch Ziekenhuis Maastricht / afdeling longziekten en tuberculose, Maastricht

0424

Oslo universitetssykehus HF - Radiumhospitalet, Oslo

3041-801

Centro Hospitalar e Universitario de Coimbra - Hospital Geral, Coimbra

1099-023

Instituto Português de Oncologia de Lisboa, Prof. Francisco Gentil E.P.E., Lisbon

1769-001

Centro Hospitalar de Lisboa Norte - Hospital Pulido Valente, Lisbon

4434-502

Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E., Vila Nova de Gaia

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Sungkyunkwan Univ. School of Medicine, Seoul

03203

Hospital General Universitario de Elche, Elche

08036

Hospital Clinic I Provincial de Barcelona, Barcelona

08035

Hospital Universitari Vall D'Hebron, Barcelona

CH-4031

Universitaetsspital Basel, Basel

CH-8401

Kantonsspital Winterthur, Winterthur

03115

Kyiv City Clinical Oncologic Center/Department of Chemotherapy, Kyiv

CB2 0QQ

Addenbrooke's Hospital, Oncology Centre, Cambridge

SG1 4AB

Lister Hospital, Stevenage

AL7 4HQ

Queen Elizabeth II Hospital, Welwyn Garden City

M16 8AJ

Spire Manchester Hospital, Manchester

HA6 2RN

Mount Vernon Hospital, Mount Vernon Cancer Centre, Northwood

G12 0YN

NHS Greater Glasgow and Clyde Health Board, Beatson West of Scotland Cancer Centre,, Glasgow

G52 3NQ

Ross Hall Hospital, Glasgow

AB25 2ZN

Aberdeen Royal Infirmary, Aberdeen

M20 4BX

The Christie Hospital NHS Foundation Trust, Department of Medical Oncology, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY