416
Participants
Start Date
August 31, 2010
Primary Completion Date
August 31, 2012
Study Completion Date
December 31, 2012
exenatide injection
Patients in exenatide group will be treated with exenatide (Byetta®, Eli Lilly and Company) 5 µg BID for the first 4 weeks and then 10 µg BID thereafter.
Mixed Protamine Zinc Recombinant Human Insulin Lispro 25R
Patients in insulin group will be treated with premixed insulin analog (Humalog Mix 25, Eli Lilly and Company). The initial insulin doses are 0.4 IU/kg per day(50% before breakfast and 50% before dinner). Insulin doses are titrated following a forced schedule according to blood glucose before breakfast and dinner.
Pioglitazone
Patients in thiazolidinedione group will be treated with Pioglitazone 30mg daily as single dose. The dose will be increased to 45mg daily after 4 weeks.
China-Japan Friendship Hospital, Beijing
Peking University People's Hospital, Beijing
Beijing Hospital, Beijing
Chinese PLA General Hospital, Beijing
China Medical University, Shenyang
Second Xiangya Hospital of Central-south University, Changsha
The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou
The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou
Qingyuan People's hospital, Qingyuan
The first Affiliated Hospital of Shantou University Medical College, Shantou
Shenzhen Second People's Hospital, Shenzhen
Affiliated hospital of Guangdong medical college, Zhanjiang
The first affiliated hospital of Guangxi Medical College, Nanning
Peking University First Hospital, Beijing
The Military General Hospital of Beijing PLA, Beijing
The Affiliated Hospital of Guiyang Medical College, Guiyang
The 2nd Affiliated Hospital of Harbin Medical University, Harbin
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan
The Affiliated Hospital of Inner Mangolia Medical College, Hohhot
Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing
The First Affiliated Hospital of Nanjing Medical University, Nanjing
Zhongda Hospital of Southeast University, Nanjing
Xijing Hospital of The Fourth Military Medical University, Xi'an
The First Affiliated Hospital of Kunming Medical College, Kunming
The First Affiliated Hospital of Chongqing Medical University, Chongqing
Collaborators (1)
Eli Lilly and Company
INDUSTRY
Amylin Pharmaceuticals, LLC.
INDUSTRY
Ministry of Health, China
OTHER_GOV
Sun Yat-sen University
OTHER