Efficacy and Safety Study of Abatacept Subcutaneous Plus Methotrexate in Inducing Remission in Adults With Very Early Rheumatoid Arthritis

PHASE3CompletedINTERVENTIONAL
Enrollment

511

Participants

Timeline

Start Date

December 31, 2010

Primary Completion Date

September 30, 2013

Study Completion Date

October 31, 2014

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Abatacept

Injection, subcutaneous, 125 mg by syringe, once weekly, 12 months

DRUG

Methotrexate

Tablets, oral, 2.5 mg, once weekly, 12 months

DRUG

Abatacept placebo

Injection, subcutaneous, to match 125 mg by syringe, once weekly, 12 months

DRUG

Methotrexate placebo

Tablets, oral, to match 2.5-mg tablet, once weekly, 12 months

Trial Locations (73)

1200

Local Institution, Brussels

1619

Local Institution, Kempton Park

2170

Local Institution, Merksem

3084

Local Institution, Heidelberg

3144

Local Institution, Malvern

4001

Local Institution, Durban

4558

Local Institution, Maroochydore

4870

Local Institution, Cairns

5011

Local Institution, Woodville

6100

Local Institution, Victoria Park

7500

Local Institution, Panorama

8500

Local Institution, Kortrijk

9800

Local Institution, Hjørring

10117

Local Institution, Berlin

14059

Local Institution, Berlin

16635

Alan J. Kivitz, Md, Cpi, Duncansville

21224

Johns Hopkins University Division Of Rheumatology, Baltimore

28401

Carolina Arthritis Associates, Wilmington

28602

Piedmont Rheumatology, Pa, Hickory

29118

Mitchell C. Feinman, Md, Orangeburg

31000

Local Institution, Chihuahua City

31134

Local Institution, Hildesheim

33521

Local Institution, Tampere

34239

Sarasota Arthritis Research Center, Sarasota

34295

Local Institution, Montpellier

35801

Rheumatology Associates Of North Alabama, P.C., Huntsville

37170

Local Institution, Chambray-lès-Tours

39202

Arthritis Associates Of Mississippi, Jackson

44109

Metrohealth Medical Center, Cleveland

44130

Isam A. Diab, Md, Middleburg

44500

Local Institution, Guadalajara

44690

Local Institution, Guadalajara

52140

Local Institution, Metepec

53100

Local Institution, Siena

53217

Kurt Oelke, Md, Glendale

60055

Local Institution, Ancona

64020

Local Institution, Monterrey

68516

Physician Research Collaboration, Llc, Lincoln

71913

St. Joseph'S Mercy Clinic, Hot Springs

75679

Local Institution, Paris

76178

Local Institution, Querétaro

78240

Local Institution, San Luis Potosí City

80336

Local Institution, München

80639

Local Institution, München

81541

Local Institution, München

83814

Coeur D'Alene Arthrit Clin, Coeur d'Alene

86021

Local Institution, Poitiers

87100

Local Institution, Torun

97000

Local Institution, Mérida

117049

Local Institution, Moscow

129327

Local Institution, Moscow

170036

Local Institution, Tver'

01605

Clinical Pharmacology Study Group, Worcester

T2N 4N1

Local Institution, Calgary

H7T 2P5

Local Institution, Laval

00290

Local Institution, Helsinki

20-954

Local Institution, Lublin

60-218

Local Institution, Poznan

01-157

Local Institution, Warsaw

01-868

Local Institution, Warsaw

50-088

Local Institution, Wroc#aw

0083

Local Institution, Pretoria

0084

Local Institution, Pretoria

0181

Local Institution, Pretoria

705-718

Local Institution, Daegu

302-799

Local Institution, Daejeon

133-791

Local Institution, Seoul

137-701

Local Institution, Seoul

413 45

Local Institution, Gothenburg

581 85

Local Institution, Linköping

205 02

Local Institution, Malmo

171 76

Local Institution, Stockholm

751 85

Local Institution, Uppsala

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY