Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

94

Participants

Timeline

Start Date

September 21, 2010

Primary Completion Date

July 15, 2014

Study Completion Date

March 19, 2026

Conditions
Metastatic Esophageal AdenocarcinomaMetastatic Esophageal Squamous Cell CarcinomaMetastatic Gastroesophageal Junction AdenocarcinomaRecurrent Esophageal AdenocarcinomaRecurrent Esophageal CarcinomaRecurrent Esophageal Squamous Cell CarcinomaRecurrent Gastroesophageal Junction AdenocarcinomaStage IV Esophageal Cancer AJCC v7
Interventions
BIOLOGICAL

Cixutumumab

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Paclitaxel

Given IV

OTHER

Pharmacological Study

Correlative studies

Trial Locations (233)

12208

New York Oncology Hematology PC - Albany Medical Center, Albany

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

16001

Butler Memorial Hospital, Butler

16801

Geisinger Medical Group, State College

17822

Geisinger Medical Center, Danville

18015

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18508

Hematology and Oncology Associates of North East Pennsylvania, Scranton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19010

Bryn Mawr Hospital, Bryn Mawr

19096

Lankenau Medical Center, Wynnewood

Main Line Health NCORP, Wynnewood

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19301

Paoli Memorial Hospital, Paoli

19464

Pottstown Hospital, Pottstown

19611

Reading Hospital, West Reading

19718

Christiana Care Health System-Christiana Hospital, Newark

19958

Beebe Medical Center, Lewes

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

21921

Christiana Care - Union Hospital, Elkton

22401

Fredericksburg Oncology Inc, Fredericksburg

26003

Wheeling Hospital/Schiffler Cancer Center, Wheeling

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

38301

Jackson-Madison County General Hospital, Jackson

43402

Toledo Clinic Cancer Centers-Bowling Green, Bowling Green

43410

North Coast Cancer Care-Clyde, Clyde

43537

Saint Luke's Hospital, Maumee

Toledo Clinic Cancer Centers-Maumee, Maumee

43560

ProMedica Flower Hospital, Sylvania

43567

Fulton County Health Center, Wauseon

43606

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

43608

Mercy Health - Saint Vincent Hospital, Toledo

43614

University of Toledo, Toledo

43616

Saint Charles Hospital, Oregon

Toledo Clinic Cancer Centers-Oregon, Oregon

43617

Toledo Community Hospital Oncology Program CCOP, Toledo

43623

Mercy Health - Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

44035

Hematology Oncology Center Incorporated, Elyria

Mercy Cancer Center-Elyria, Elyria

44109

MetroHealth Medical Center, Cleveland

44304

Summa Health System - Akron Campus, Akron

44708

Cleveland Clinic Mercy Hospital, Canton

44857

Fisher-Titus Medical Center, Norwalk

44870

North Coast Cancer Care, Sandusky

44883

Mercy Hospital of Tiffin, Tiffin

45801

Saint Rita's Medical Center, Lima

45804

Lima Memorial Hospital, Lima

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis

Sidney and Lois Eskenazi Hospital, Indianapolis

46219

IU Health Central Indiana Cancer Centers-East, Indianapolis

46350

IU Health La Porte Hospital, La Porte

46360

Franciscan Saint Anthony Health-Michigan City, Michigan City

46515

Elkhart General Hospital, Elkhart

46545

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka

46601

Memorial Hospital of South Bend, South Bend

46628

Northern Indiana Cancer Research Consortium, South Bend

46904

Community Howard Regional Health, Kokomo

47303

IU Health Ball Memorial Hospital, Muncie

48060

Lake Huron Medical Center, Port Huron

48093

Henry Ford Health Warren Hospital, Warren

48106

Michigan Cancer Research Consortium NCORP, Ann Arbor

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48124

Corewell Health Dearborn Hospital, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48162

Mercy Memorial Hospital, Monroe

Toledo Clinic Cancer Centers-Monroe, Monroe

48236

Henry Ford Health Saint John Hospital, Detroit

48341

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

Hurley Medical Center, Flint

48532

Genesys Regional Medical Center-West Flint Campus, Flint

48601

MyMichigan Medical Center Saginaw, Saginaw

48912

University of Michigan Health - Sparrow Lansing, Lansing

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49048

Beacon Kalamazoo, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49201

Allegiance Health, Jackson

49221

Bixby Medical Center, Adrian

Hickman Cancer Center, Adrian

50010

McFarland Clinic - Ames, Ames

50309

Iowa Methodist Medical Center, Des Moines

Iowa-Wide Oncology Research Coalition NCORP, Des Moines

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50401

Mercy Medical Center - North Iowa, Mason City

51101

Siouxland Regional Cancer Center, Sioux City

51102

Mercy Medical Center-Sioux City, Sioux City

51104

Saint Luke's Regional Medical Center, Sioux City

52403

Mercy Hospital, Cedar Rapids

Oncology Associates at Mercy Medical Center, Cedar Rapids

53038

University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek

53081

HSHS Saint Nicholas Hospital, Sheboygan

53715

SSM Health Dean Medical Group - South Madison Campus, Madison

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54143

Bay Area Medical Center, Marinette

54221

Holy Family Memorial Hospital, Manitowoc

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

54494

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54601

Gundersen Lutheran Medical Center, La Crosse

55082

Lakeview Hospital, Stillwater

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro Minnesota Community Oncology Research Consortium, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55805

Essentia Health Cancer Center, Duluth

Essentia Health Saint Mary's Medical Center, Duluth

Miller-Dwan Hospital, Duluth

55905

Mayo Clinic in Rochester, Rochester

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

56401

Essentia Health Saint Joseph's Medical Center, Brainerd

58103

Essentia Health Cancer Center-South University Clinic, Fargo

60035

Hematology Oncology Associates of Illinois-Highland Park, Highland Park

60048

AMG Libertyville - Oncology, Libertyville

60076

Hematology Oncology Associates of Illinois - Skokie, Skokie

60305

West Suburban Medical Center, River Forest

60402

MacNeal Hospital and Cancer Center, Berwyn

60426

Ingalls Memorial Hospital, Harvey

60435

Duly Health and Care Joliet, Joliet

60504

Rush-Copley Medical Center, Aurora

60521

Hinsdale Hematology Oncology Associates Incorporated, Hinsdale

60563

DuPage Medical Group-Ogden, Naperville

60611

Hematology and Oncology Associates, Chicago

Northwestern University, Chicago

60714

Illinois Cancer Specialists-Niles, Niles

60901

Presence Saint Mary's Hospital, Kankakee

61104

Swedish American Hospital, Rockford

61265

Trinity Medical Center, Moline

61350

Ottawa Regional Hospital and Healthcare Center, Ottawa

61354

Illinois Valley Hospital, Peru

61356

Perry Memorial Hospital, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61455

Mcdonough District Hospital, Macomb

61520

Graham Hospital Association, Canton

61530

Eureka Hospital, Eureka

61554

OSF Saint Francis Radiation Oncology at Pekin, Pekin

61614

Proctor Hospital, Peoria

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

OSF Saint Joseph Medical Center, Bloomington

61761

Carle BroMenn Medical Center, Normal

Carle Cancer Institute Normal, Normal

61801

Carle Cancer Center, Urbana

62321

Memorial Hospital, Carthage

62526

Decatur Memorial Hospital, Decatur

Heartland Cancer Research NCORP, Decatur

62644

Mason District Hospital, Havana

62781

Springfield Memorial Hospital, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

Wichita NCI Community Oncology Research Program, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67801

Cancer Center of Kansas - Dodge City, Dodge City

67905

Cancer Center of Kansas-Liberal, Liberal

68106

Missouri Valley Cancer Consortium, Omaha

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68510

Nebraska Cancer Research Center, Lincoln

70112

Louisiana State University Health Science Center, New Orleans

University Medical Center New Orleans, New Orleans

70809

Mary Bird Perkins Cancer Center, Baton Rouge

80012

The Medical Center of Aurora, Aurora

80113

Swedish Medical Center, Englewood

80122

AdventHealth Littleton, Littleton

80124

Sky Ridge Medical Center, Lone Tree

80138

AdventHealth Parker, Parker

80210

AdventHealth Porter, Denver

80218

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Saint Joseph Hospital - Cancer Centers of Colorado, Denver

80220

Rose Medical Center, Denver

80222

Western States Cancer Research NCORP, Denver

80228

Saint Anthony Hospital, Lakewood

80229

North Suburban Medical Center, Thornton

80303

Boulder Community Foothills Hospital, Boulder

80401

Intermountain Health Lutheran Hospital, Wheat Ridge

80501

Longmont United Hospital, Longmont

80539

Banner McKee Medical Center, Loveland

80631

Banner North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81501

Saint Mary's Hospital and Regional Medical Center, Grand Junction

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

85259

Mayo Clinic in Arizona, Scottsdale

94304

Stanford Cancer Institute Palo Alto, Palo Alto

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

32224-9980

Mayo Clinic in Florida, Jacksonville

08103

Cooper Hospital University Medical Center, Camden

07018-1095

Veterans Adminstration New Jersey Health Care System, East Orange

07728

CentraState Medical Center, Freehold

08690

The Cancer Institute of New Jersey Hamilton, Hamilton

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

07101

Rutgers New Jersey Medical School, Newark

07112

Newark Beth Israel Medical Center, Newark

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH