Effects of Sildenafil on CFTR-dependent Ion Transport Activity

PHASE2CompletedINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

October 31, 2015

Primary Completion Date

May 31, 2017

Study Completion Date

May 31, 2017

Conditions
Cystic Fibrosis
Interventions
DRUG

Sildenafil

During the course of the study, patients will receive 4 weeks of therapy: 28 days of placebo orally t.i.d. or 28 days of days of sildenafil orally t.i.d. Dosing of sildenafil will be escalated after the first week (20 mg orally t.i.d for the first week, then subjects will take 40 mg orally t.i.d. for 3 weeks). Patients not tolerating dose escalation will be discontinued from the study.

DRUG

Placebo

Patients receiving placebo will have sham dose escalation to maintain blinding.

Trial Locations (1)

80206

National Jewish Health, Denver

All Listed Sponsors
lead

National Jewish Health

OTHER

NCT01132482 - Effects of Sildenafil on CFTR-dependent Ion Transport Activity | Biotech Hunter | Biotech Hunter