1,095
Participants
Start Date
July 31, 2010
Primary Completion Date
September 30, 2014
Study Completion Date
September 16, 2016
docetaxel
75 mg/m2 or 100 mg/m2 intravenously every 3 weeks for a minimum of 6 cycles.
paclitaxel
80 mg/m2 intravenously weekly for a minimum of 18 weeks
pertuzumab
840 mg intravenously on day 1 of cycle 1 followed by 420 mg intravenously every 3 weeks in subsequent cycles
pertuzumab-placebo
840 mg intravenously on day 1 of cycle 1 followed by 420 mg intravenously every 3 weeks in subsequent cycles
trastuzumab [Herceptin]
trastuzumab \[Herceptin\] doses when administered with docetaxel: 8 mg/kg intravenously on cycle 1 followed by 6 mg/kg every 3 weeks in subsequent cycles or trastuzumab (Herceptin) doses when administered with paclitaxel: 4 mg/kg intravenously on day 1 of cycle 1 followed by 2 mg/kg weekly starting on day 8 of cycle 1.
trastuzumab emtansine
3.6 mg/kg intravenously every 3 weeks
Hospital Nacional Edgardo Rebagliati Martins; Oncologia, Lima
National Taiwan Uni Hospital; Dept of Oncology, Taipei
Tri-Service General Hospital; Hematology and Oncology, Taipei
Changhua Christian Hospital; Hematology-Oncology, Changhua
Kaohsiung Medical Uni Chung-Ho Hospital; Dept of Surgery, Kaohsiung City
Private Health Organization Acibadem Sistina Hospital, Skopje
Auckland city hospital; Auckland Regional Cancer Centre and Blood Service, Auckland
Fundación Investigar, Buenos Aires
Szent Margit Hospital; Dept. of Oncology, Budapest
Semmelweis Egyetem Onkologiai Központ, Budapest
Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie, Vienna
Semmelweis Egyetem Aok; Iii.Sz. Belgyogyaszati Klinika, Budapest
Cliniques Universitaires St-Luc, Brussels
Cardinal Santos Medical Center, San Juan City
Mater Misericordiae Hospital; Chemotherapy Cottage, Sydney
Calvary Mater Newcastle; Medical Oncology, Waratah
Sint Augustinus Wilrijk, Wilrijk
Peter Maccallum Cancer Institute; Medical Oncology, Melbourne
Universitaetsspital Basel; Onkologie, Basel
Wesley Medical Centre; Clinic For Haematology and Oncology, Auchenflower
Royal Adelaide Hospital; Oncology, Adelaide
Clinique Ste-Elisabeth, Namur
Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt., Salzburg
Kantonsspital Baden; Medizinische Klinik, Onkologie, Baden
Cebu Cancer Institute; Perpetual Succour Hospital, Cebu City
Kantonsspital Graubünden Medizin Onkologie; Onkologie und Hämatologie, Chur
Vejle Sygehus; Onkologisk Afdeling, Vejle
Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet, Pécs
Icahn School of Medicine at Mount Sinai, New York
Weill Medical College of Cornell Uni, New York
National Cancer Inst., Bangkok
Rajavithi Hospital; Division of Medical Oncology, Bangkok
Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc, Bangkok
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology, Bangkok
Clinica del Country, Bogotá
Arena Oncology Associates, Lake Success
Queens Medical Associates, Fresh Meadows
Queens Hospital Center, Jamaica
Institut Paoli Calmettes; Oncologie Medicale, Marseille
Complejo Hospitalario Universitario A Coruña (CHUAC, Materno Infantil), Oncología, A Coruña
Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia, Santiago de Compostela
Penn State Milton S. Hershey Medical Center, Hershey
Unidad de Investigacion Oncologia Clinica ? Piura; Unidad de Oncología Clínica, Piura
IRCCS Istituto Clinico Humanitas; Oncologia, Rozzano (MI)
Istituto Europeo Di Oncologia, Milan
Centenario Hospital Miguel Hidalgo, Aguascalientes
Facharztzentrum Eppendorf, Studien GbR, Hamburg
Anne Arundel Health System Research Instit-Annapolis Oncology Ctr, Annapolis
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia, Jaén
HOPITAL JEAN MINJOZ; Oncologie, Besançon
Fondazione Salvatore Maugeri, Pavia
Marion L. Shepard Cancer Center, Washington
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid
Hospital Universitario La Paz; Servicio de Oncologia, Madrid
Carolinas Hem-Oncology Assoc, Charlotte
Carolina Oncology Specialists, PA - Hickory, Hickory
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Málaga
South Carolina Oncology Associates - SCRI, Columbia
Charleston Oncology, P .A, Charleston
Medical University of SC (MUSC), Charleston
MVZ Onko Medical GmbH Hannover, Ralf Lohse (Geschäftsführer), Hanover
University Cancer & Blood Center, LLC; Research, Athens
Mayo Clinic-Jacksonville, Jacksonville
Mühlenkreiskliniken; Johannes Wesling Klinikum Minden; Klinik für Frauenheilkunde und Geburtshilfe, Minden
Azienda Ospedaliero-Universitaria Dipartimento Interaziendale Di Oncologia, Udine
Uni of Miami School of Medicine; Sylvester Comprehensive Cancer Center, Miami
Innovative Medical Research of South Florida, Aventura
Florida Cancer Specialists; SCRI, Fort Myers
Institut régional du Cancer Montpellier, Montpellier
Ege Uni Medical Faculty Hospital; Oncology Dept, Izmir
Tennessee Onc., PLLC - SCRI, Nashville
Vanderbilt-Ingram Cancer Ctr, Nashville
SCRI Tennessee Oncology Chattanooga, Chattanooga
West Clinic, Germantown
Universitätsklinikum Magdeburg; Frauenheilkunde & Geburtshilfe, Magdeburg
Centro de Investigacion; Clinica Del Pacifico, Acapulco de Juárez
James Graham Brown Cancer Center, University of Louisville, Louisville
A.O. Universitaria Policlinico Di Modena; Ematologia, Modena
Arcispedale Santa Maria Nuova; Oncologia, Reggio Emilia
Institut de Cancerologie de La Loire; Radiotherapie, Saint-Priest-en-Jarez
Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum, Essen
Oncology Hematology Care - SCRI, Cincinnati
Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia
Beacon International Specialist Centre, Petaling Jaya, Selangor
Sunway Medical Centre, Kuala Selangor
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola
Ospedale Degli Infermi; Divisione Di Oncologia, Rimini
Horizon Oncology Research, Inc., Lafayette
Spectrum Health Grand Rapids, Grand Rapids
Centro Oncológico Estatal; ISSSEMYM Oncología, Toluca
Maharaj Nakorn Hospital; Internal Medicine, Chiang Mai
Centre D'Oncologie de Gentilly; Oncology, Nancy
Klinikum Mutterhaus der Borromaeerinnen gGmbH; Haematologie/Onkologie, Trier
Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde, Mainz
University of Minnesota., Minneapolis
Mayo Clinic Rochester, Rochester
Avera Cancer Institute, Sioux Falls
Sanford Roger Maris Cancer Center, Fargo
Centre Oscar Lambret; Senologie, Lille
Ospedale Misericordia E Dolce; Oncologia Medica, Prato
Pantai Hospital Kuala Lumpur; Dept of Oncology & Radiotherapy, Kuala Lumpur
Loyola University Med Center, Maywood
Ingalls Memorial Hospital, Harvey
Uni of Chicago, Chicago
Illinois Cancer Care, Peoria
Decatur Memorial Hospital, Decatur
Centre Jean Perrin; Hopital De Jour, Clermont-Ferrand
St. John'S Mercy Medical Center; David C. Pratt Cancer Center, St Louis
Centro Universitario Contra El Cancer, Monterrey
Mercy Clinic Cancer & Hematology, Springfield
Oaxaca Site Management Organization, Oaxaca City
Nationales Centrum für Tumorerkrankungen (NCT) ; Gyn. Onk. Frauenklinik; Uniklinikum Heidelberg, Heidelberg
Clinic of Oncology, University Clinical Center Sarajevo, Sarajevo
Uni of Arkansas For Medical Sciences; Arkansas Cancer Research Center, Little Rock
Institut Curie; Oncologie Medicale, Paris
Hopital Saint Louis; Service Onco Thoracique, Paris
HOPITAL TENON; Cancerologie Medicale, Paris
Uni of Texas - Md Anderson Cancer Center; Dept of Breast Medical Oncology, Houston
University Clinical Centre of the Republic of Srpska, Banja Luka
The Don & Sybil Harrington Cancer Center; Department of Clinical Research, Amarillo
Rotkreuzklinikum München; Frauenklinik, München
Mountain States Tumor Inst., Boise
Northern Utah Associates, Ogden
Hospital Privado San Jose; Oncologia, Obregón
Chu La Miletrie; Radiotherapie, Poitiers
San Juan Oncology Associates, Farmington
Campus Universitario S.Venuta; Centro Oncologico T.Campanella, Catanzaro
Songklanagarind Hospital; Department of Oncology, Songkhla
Clnc L Trials & Rsch Assoc-Inc, Montebello
Scripps Cancer Center, La Jolla
University of California; Moores Cancer Center, La Jolla
Southern California Kaiser Permanente, San Diego
Centre Rene Huguenin; ONCOLOGIE GENETIQUE, Saint-Cloud
Breastlink Medical Group Inc, Santa Ana
Kaiser Permanente; Oncology Clinical Trials, Vallejo
Centro Catanese Di Oncologia; Oncologia Medica, Catania
Cancer Research Center of Hawaii; Clinical Sciences, Honolulu
Ospedale Papardo- Piemonte;Oncologia Medica, Messina
University of Washington, Seattle
The Providence Regional Medical Center Everett, Everett
Northwest Medical Specialties, Tacoma
Blokhin Cancer Research Center; Combined Treatment, Moskva
Moscow city oncology hospital; #62 of Moscow Healthcare Department, Moscow
Ivanovo Regional Oncology Dispensary, Ivanovo
Tula Regional Oncology Dispensary, Tula
SBI of Healthcare of Stavropol region Stavropol Regional Clinical Oncology Dispensary, Stavropol
State Budget Institution of Healthcare of Stavropol region Pyatigorsk Oncology Dispensary, Pyatigorsk
Ryazan State Medical University Named after I.P.Pavlov, Ryazan
Cluj Clinical County Hospital; Oncology Dept, Cluj-Napoca
Prof. Dr. I. Chiricuta Institute of Oncology, Cluj-Napoca
Clinical Oncology Dispensary of Ministry of Health of Tatarstan, Kazan'
SBI of Healthcare Samara Regional Clinical Oncology Dispensary, Samara
GUZ Vladimir Regional Clinical Oncological Dispensary, Vladimir
Liga Norte Riograndense Contra O Câncer, Natal
Smilow Cancer Hospital at Yale New Haven, New Haven
Northwest Oncology/ Hematology Assoc., Coral Springs
New England Cancer Specialists, Scarborough
Boston Medical Center, Boston
Dartmouth Hitchcock Med Center, Lebanon
Hackensack Uni Medical Center; Northern Nj Cancer Center, Hackensack
Cancer Inst. of New Jersey, New Brunswick
Uni of Texas Southwestern Medical Center, Dallas
Centro Medico San Roque, San Miguel de Tucumán
*X*Instituto Nacional do Cancer - INCA, Rio de Janeiro
Hospital Nossa Senhora da Conceicao, Porto Alegre
Clinica de Oncologia de Porto Alegre - CliniOnco, Porto Alegre
Hospital Sao Lucas - PUCRS, Porto Alegre
Clinica de Neoplasias Litoral, Itajaí
Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo
Hospital Perola Byington, São Paulo
Cross Cancer Institute; Clinical Trials, Edmonton
North York General Hospital, Toronto
Cuse - Centre Universitaire De Sante; Site Fleurimont, Sherbrooke
CHU de Québec ? Hôpital du Saint-Sacrement / ONCOLOGY, Québec
Instituto Colombiano Para El Avance De La Medicina: Icamedic, Bucaramanga
Instituto Cancerologico de Nariño, Pasto
Centro Medico Imbanaco, Santiago de Cali
University Hospital of Larissa; Oncology, Larissa
Waikato Hospital; Regional Cancer Center, Hamilton
Coltea Hospital; Oncology, Bucharest
Masarykuv onkologicky ustav, Brno
Fakultni nemocnice Olomouc; Onkologicka klinika, Olomouc
Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika, Prague
Fakultni Nemocnice Na Bulovce; Ustav Radiacni Onkologie, Prague
Universitätsklinikum Halle (Saale); Universitätsklinik Und Poliklinik Für Gynäkologie, Halle
Alexandras General Hospital of Athens; Oncology Department, Athens
Univ General Hosp Heraklion; Medical Oncology, Heraklion
Centro Oncológico Sixtino / Centro Oncológico SA, Guatemala City
Grupo Angeles, Guatemala City
Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia; Oncologia Medica, Perugia
Aichi Cancer Center Hospital, Breast Oncology, Aichi
Natl Hosp Org Shikoku; Cancer Ctr, Surgery, Ehime
National Hospital Organization Kyushu Cancer Center;Breast Oncology, Fukuoka
Gifu University Hospital; Digestive Surgery, Gifu
Hiroshima University Hospital; Breast Surgery, Hiroshima
National Hospital Organization Hokkaido Cancer Center; Breast Surgery, Hokkaido
Hyogo College Of Medicine; Breast And Endocrine Surgery, Hyōgo
Hyogo Cancer Center; Breast Surgery, Hyōgo
Kanazawa University Hospital; Breast Oncology, Ishikawa
Sagara Hospital; Breast Surgery, Kagoshima
Tokai University Hospital, Breast Surgery, Kanagawa
Kumamoto University Hospital; Breast and Endocrine Surgery, Kumamoto
Kumamoto City Hospital, Breast and Endocrine Surgery, Kumamoto
Kyoto University Hospital; Breast Surgery, Kyoto
Tohoku University Hospital; General Surgery, Miyagi
Niigata Cancer Ctr Hospital; Breast Surgery, Niigata
Iwate Med Univ School of Med; Surgery, Numakunai
Kawasaki Medical School Hospital; Breast and Thyroid Surgery, Okayama
National Hospital Organization Osaka National Hospital; Breast Surgery, Osaka
Osaka University Hospital; Breast and Endocrine Surgery, Osaka
Saitama Medical University International Medical Center; Medical Oncology, Saitama
Saitama Cancer Center, Breast Oncology, Saitama
Shizuoka Cancer Center; Breast Surgery, Shizuoka
Shizuoka General Hospital; Breast Surgery, Shizuoka
National Cancer Center Hospital; Medical Oncology, Tokyo
Toranomon Hospital; Breast and Endocrine Surgery, Tokyo
The Cancer Inst. Hosp. of JFCR; Breast Oncology Center, Tokyo
Tokyo Medical Uni. Hospital; Breast Oncology, Tokyo
The Panama Clinic, Panama City
Hospital Nacional Carlos Alberto Seguin Escobedo-Essalud; Oncology & Haemathology, Arequipa
Centrum Onkologii;Im. Franciszka Lukaszczyka;Onkologii, Bydgoszcz
Medical University of Gdansk, Gdansk
Centrum Onkologii, Instytut, Klinika Chemioterapii; Oddzial Chemoterapii, Krakow
COZL Oddzial Onkologii Klinicznej z pododdzialem Chemioterapii Dziennej, Lublin
Cent.Onkologii-Instytut im. M. S-Curie, Klinika Now. Piersi i Chirurgii Rekon, Warsaw
IPO do Porto; Servico de Oncologia Medica, Porto
Seoul National University Bundang Hospital; Hematology Medical Oncology, Gyeonggi-do
Seoul National Uni Hospital; Dept. of Internal Medicine/Hematology/Oncology, Seoul
Samsung Medical Centre; Division of Hematology/Oncology, Seoul
Asan Medical Center, Uni Ulsan Collegemedicine; Dept.Internal Medicine / Divisionhematology/Oncology, Seoul
Korea University Guro Hospital; Oncology, Seoul
Hospital General Universitario de Elche; Servicio de Oncologia, Elche
Hospital Univ Vall d'Hebron; Servicio de Oncologia, Sant Andreu de la Barca
Hospital del Mar; Servicio de Oncologia, Barcelona
Skånes Universitetssjukhus; Kliniska Forskningsenheten Onkologimottagning medicinsk behandling, Malmo
Oncology Consultants Limited, Nassau
Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology, Adana
Cukurova Uni Faculty of Medicine; Medical Oncology, Adana
Gazi Uni Medical Faculty Hospital; Oncology Dept, Ankara
Bristol Haematology and Oncology centre, Bristol
Cambridge University Hospitals NHS Foundation Trust, Cambridge
Royal Cornwall Hospital; Dept of Clinical Oncology, Cornwall
The Beatson West of Scotland Cancer Centre; Cancer Clinical Trials Unit, Glasgow
Leicester Royal Infirmary; Dept. of Medical Oncology, Leicester
Royal Free Hospital; Dept of Oncology, London
Guys Hospital; Management Offices, London
Royal Marsden Hospital; Dept of Med-Onc, London
Christie Hospital; Breast Cancer Research Office, Manchester
Nottingham City Hospital; Oncology, Nottingham
Peterborough City Hospital; Oncology Ward, Peterborough
Queen Alexandra Hospital, Portsmouth, Portsmouth
Weston Park Hospital; Cancer Clinical Trials Centre, Sheffield
Southampton General Hospital; Somers Cancer Research Building, Southampton
Uni Hospital of North Staffordshire; Staffordshire Oncology Centre, Stoke-on-Trent
Royal Marsden Hospital; Dept of Medical Oncology, Sutton
Collaborators (1)
Genentech, Inc.
INDUSTRY
Hoffmann-La Roche
INDUSTRY