Carboplatin and Paclitaxel or Oxaliplatin and Capecitabine With or Without Bevacizumab as First-Line Therapy in Treating Patients With Newly Diagnosed Stage II-IV or Recurrent Stage I Epithelial Ovarian or Fallopian Tube Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

October 12, 2010

Primary Completion Date

February 25, 2015

Study Completion Date

March 12, 2026

Conditions
Borderline Ovarian Mucinous TumorOvarian Mucinous CystadenocarcinomaRecurrent Fallopian Tube CarcinomaRecurrent Ovarian CarcinomaStage IA Fallopian Tube Cancer AJCC v6 and v7Stage IA Ovarian Cancer AJCC v6 and v7Stage IB Fallopian Tube Cancer AJCC v6 and v7Stage IB Ovarian Cancer AJCC v6 and v7Stage IC Fallopian Tube Cancer AJCC v6 and v7Stage IC Ovarian Cancer AJCC v6 and v7Stage IIA Fallopian Tube Cancer AJCC v6 and v7Stage IIA Ovarian Cancer AJCC V6 and v7Stage IIB Fallopian Tube Cancer AJCC v6 and v7Stage IIB Ovarian Cancer AJCC v6 and v7Stage IIC Fallopian Tube Cancer AJCC v6 and v7Stage IIC Ovarian Cancer AJCC v6 and v7Stage IIIA Fallopian Tube Cancer AJCC v7Stage IIIA Ovarian Cancer AJCC v6 and v7Stage IIIB Fallopian Tube Cancer AJCC v7Stage IIIB Ovarian Cancer AJCC v6 and v7Stage IIIC Fallopian Tube Cancer AJCC v7Stage IIIC Ovarian Cancer AJCC v6 and v7Stage IV Fallopian Tube Cancer AJCC v6 and v7Stage IV Ovarian Cancer AJCC v6 and v7
Interventions
BIOLOGICAL

Bevacizumab

Given IV

DRUG

Capecitabine

Given PO

DRUG

Carboplatin

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Oxaliplatin

Given IV

DRUG

Paclitaxel

Given IV

OTHER

Quality-of-Life Assessment

Ancillary studies

Trial Locations (248)

11794

Stony Brook University Medical Center, Stony Brook

13210

State University of New York Upstate Medical University, Syracuse

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

16801

Geisinger Medical Group, State College

17822

Geisinger Medical Center, Danville

18015

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19001

Jefferson Abington Hospital, Abington

19718

Christiana Care Health System-Christiana Hospital, Newark

19958

Beebe Medical Center, Lewes

21204

Greater Baltimore Medical Center, Baltimore

21921

Christiana Care - Union Hospital, Elkton

22408

Hematology Oncology Associates of Fredericksburg Inc, Fredericksburg

24501

Centra Alan B Pearson Regional Cancer Center, Lynchburg

24541

Danville Regional Medical Center, Danville

27104

Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem

27157

Wake Forest University Health Sciences, Winston-Salem

27534

Wayne Memorial Hospital, Goldsboro

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

Duke University Medical Center, Durham

28792

AdventHealth Hendersonville, Hendersonville

29303

Spartanburg Medical Center, Spartanburg

29601

Saint Francis Hospital, Greenville

29621

AnMed Health Cancer Center, Anderson

AnMed Health Hospital, Anderson

30501

Northeast Georgia Medical Center-Gainesville, Gainesville

30912

Augusta University Medical Center, Augusta

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

31904

John B Amos Cancer Center, Columbus

32610

University of Florida Health Science Center - Gainesville, Gainesville

32803

AdventHealth Orlando, Orlando

35233

University of Alabama at Birmingham Cancer Center, Birmingham

36688

University of South Alabama Mitchell Cancer Institute, Mobile

37920

University of Tennessee - Knoxville, Knoxville

39216

University of Mississippi Medical Center, Jackson

40536

University of Kentucky/Markey Cancer Center, Lexington

41017

Saint Elizabeth Healthcare Edgewood, Edgewood

41501

Pikeville Medical Center, Pikeville

43015

Grady Memorial Hospital, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43210

Ohio State University Comprehensive Cancer Center, Columbus

43213

Mount Carmel East Hospital, Columbus

43214

Riverside Methodist Hospital, Columbus

43215

Columbus NCI Community Oncology Research Program, Columbus

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43311

Mary Rutan Hospital, Bellefontaine

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44195

Cleveland Clinic Foundation, Cleveland

44304

Summa Health System - Akron Campus, Akron

44710

Aultman Health Foundation, Canton

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45429

Kettering Medical Center, Kettering

45504

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45750

Marietta Memorial Hospital, Marietta

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

46260

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

46350

IU Health La Porte Hospital, La Porte

46391

Michiana Hematology Oncology PC-Westville, Westville

46514

Michiana Hematology Oncology PC-Elkhart, Elkhart

46515

Elkhart General Hospital, Elkhart

46545

Cancer Care Partners LLC, Mishawaka

Michiana Hematology Oncology PC-Mishawaka, Mishawaka

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka

46563

Michiana Hematology Oncology PC-Plymouth, Plymouth

46601

Memorial Hospital of South Bend, South Bend

46617

South Bend Clinic, South Bend

46628

Northern Indiana Cancer Research Consortium, South Bend

46904

Community Howard Regional Health, Kokomo

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49048

Beacon Kalamazoo, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49829

OSF Saint Francis Hospital and Medical Group, Escanaba

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Iowa-Wide Oncology Research Coalition NCORP, Des Moines

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

51101

Siouxland Regional Cancer Center, Sioux City

51102

Mercy Medical Center-Sioux City, Sioux City

51104

Saint Luke's Regional Medical Center, Sioux City

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

54143

Bay Area Medical Center, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54221

Holy Family Memorial Hospital, Manitowoc

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54601

Gundersen Lutheran Medical Center, La Crosse

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58501

Mid Dakota Clinic, Bismarck

Saint Alexius Medical Center, Bismarck

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

Saint Vincent Healthcare, Billings

59102

Montana Cancer Consortium NCORP, Billings

Saint Vincent Frontier Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59501

Northern Montana Hospital, Havre

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59715

Bozeman Health Deaconess Hospital, Bozeman

59802

Montana Cancer Specialists, Missoula

Saint Patrick Hospital - Community Hospital, Missoula

59901

Glacier Oncology PLLC, Kalispell

Kalispell Medical Oncology, Kalispell

Logan Health Medical Center, Kalispell

60521

Sudarshan K Sharma MD Limited-Gynecologic Oncology, Hinsdale

60637

University of Chicago Comprehensive Cancer Center, Chicago

61104

Swedish American Hospital, Rockford

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

Ottawa Regional Hospital and Healthcare Center, Ottawa

61354

Illinois CancerCare-Peru, Peru

Illinois Valley Hospital, Peru

61356

Illinois CancerCare-Princeton, Princeton

Perry Memorial Hospital, Princeton

61362

Illinois CancerCare-Spring Valley, Spring Valley

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

Mcdonough District Hospital, Macomb

61462

Holy Family Medical Center, Monmouth

Illinois CancerCare-Monmouth, Monmouth

61520

Graham Hospital Association, Canton

Illinois CancerCare-Canton, Canton

61530

Eureka Hospital, Eureka

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin, Pekin

61614

Proctor Hospital, Peoria

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

OSF Saint Joseph Medical Center, Bloomington

61704

Illinois CancerCare-Bloomington, Bloomington

61761

Carle BroMenn Medical Center, Normal

Carle Cancer Institute Normal, Normal

Illinois CancerCare-Community Cancer Center, Normal

62321

Illinois CancerCare-Carthage, Carthage

Memorial Hospital, Carthage

62526

Heartland Cancer Research NCORP, Decatur

62644

Illinois CancerCare-Havana, Havana

Mason District Hospital, Havana

63110

Washington University School of Medicine, St Louis

63131

Missouri Baptist Medical Center, St Louis

63703

Mercy Cancer Center - Cape Girardeau, Cape Girardeau

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

68114

Nebraska Methodist Hospital, Omaha

70121

Ochsner Medical Center Jefferson, New Orleans

70503

Cancer Center of Acadiana, Lafayette

72401

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75235

Parkland Memorial Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

Houston Methodist Hospital, Houston

M D Anderson Cancer Center, Houston

Memorial Hermann Texas Medical Center, Houston

80012

The Medical Center of Aurora, Aurora

80045

UCHealth University of Colorado Hospital, Aurora

80113

Swedish Medical Center, Englewood

80122

AdventHealth Littleton, Littleton

80124

Sky Ridge Medical Center, Lone Tree

80138

AdventHealth Parker, Parker

80210

AdventHealth Porter, Denver

80218

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Saint Joseph Hospital - Cancer Centers of Colorado, Denver

80220

Rose Medical Center, Denver

80222

Western States Cancer Research NCORP, Denver

80228

Saint Anthony Hospital, Lakewood

80229

North Suburban Medical Center, Thornton

80303

Boulder Community Foothills Hospital, Boulder

80401

Intermountain Health Lutheran Hospital, Wheat Ridge

80501

Longmont United Hospital, Longmont

80524

Poudre Valley Hospital, Fort Collins

80539

Banner McKee Medical Center, Loveland

80631

Banner North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81501

Saint Mary's Hospital and Regional Medical Center, Grand Junction

82609

Rocky Mountain Oncology, Casper

82801

Welch Cancer Center, Sheridan

85013

Saint Joseph's Hospital and Medical Center, Phoenix

87106

Southwest Gynecologic Oncology Associates Inc, Albuquerque

University of New Mexico Cancer Center, Albuquerque

89106

Women's Cancer Center of Nevada, Las Vegas

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

91342

Olive View-University of California Los Angeles Medical Center, Sylmar

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94040

El Camino Hospital, Mountain View

94538

Valley Medical Oncology Consultants-Fremont, Fremont

94546

East Bay Radiation Oncology Center, Castro Valley

Valley Medical Oncology Consultants-Castro Valley, Castro Valley

94602

Wilma Chan Highland Hospital, Oakland

94608

Bay Area Breast Surgeons Inc, Emeryville

Epic Care Partners in Cancer Care, Emeryville

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

Bay Area Tumor Institute, Oakland

Hematology and Oncology Associates-Oakland, Oakland

Tom K Lee Inc, Oakland

94806

Doctors Medical Center- JC Robinson Regional Cancer Center, San Pablo

96813

Queen's Medical Center, Honolulu

University of Hawaii Cancer Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

94553-3156

Contra Costa Regional Medical Center, Martinez

06102

Hartford Hospital, Hartford

06050

The Hospital of Central Connecticut, New Britain

06904

Stamford Hospital/Bennett Cancer Center, Stamford

46514-2098

Elkhart Clinic, Elkhart

50266-7700

Methodist West Hospital, West Des Moines

20889-5600

Walter Reed National Military Medical Center, Bethesda

01199

Baystate Medical Center, Springfield

08103

Cooper Hospital University Medical Center, Camden

08060

Virtua Memorial, Mount Holly

08043

Virtua Voorhees, Voorhees Township

02905

Women and Infants Hospital, Providence

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

77555-0565

University of Texas Medical Branch, Galveston

54301-3526

Green Bay Oncology at Saint Vincent Hospital, Green Bay

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH