Study Comparing Carfilzomib, Lenalidomide, and Dexamethasone (CRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects With Relapsed Multiple Myeloma

PHASE3CompletedINTERVENTIONAL
Enrollment

792

Participants

Timeline

Start Date

July 14, 2010

Primary Completion Date

June 16, 2014

Study Completion Date

December 5, 2017

Conditions
Relapsed Multiple Myeloma
Interventions
DRUG

Dexamethasone

40 mg orally or IV on days 1, 8, 15, 22

DRUG

Lenalidomide

25 mg orally on days 1-21

DRUG

Carfilzomib

20 mg/m², 27 mg/m² intravenously

Trial Locations (127)

1000

Institut Jules Bordet, Brussels

1090

Medizinische Universitat Wien, Vienna

UZ Brussel, Brussels

1171

Wilhelminspital der Stadt Wien, Zentrum fur Onkologie und Hamatologie, Vienna

1200

Cliniques Universitaires Saint-Luc, Brussels

1606

Military Medical Academy Multiprofile Hospital for Active Treatment, Sofia

1756

Specialized Hospital for Active Treatment of Hematological Diseases, Sofia

2060

Ziekenhuisnetwerk Antwerpen - AZ Stuivenberg, Antwerp

3000

UZ Leuven, Leuven

4002

"University Multiprofile Hospital for Active Treatment Sveti Georgi", Plovdiv

5800

"University Multiprofile Hospital for Active Treatment, Dr. Georgi Stranski", Pleven

8000

AZ Sint-Jan AV, Bruges

9010

"Multiprofile Hospital for Active Treatment Sveta Marina", Varna

10016

NYU Clinical Cancer Center, New York

10021

Weill Cornell Medical College, New York

10126

Azienda Ospedaliera Citta della Salute e della Scienza di Torino, Torino

11000

Clinical Center of Serbia, Clinic of Hematology, Belgrade

Clinical Hospital Center Bezanijska Kosa, Belgrade

Military Medical Academy, Clinic of Hematology, Belgrade

11528

Alexandra Hospital, Athens

20014

Hospital Donostia, Donostia / San Sebastian

20162

Azienda Ospedallera Niguarda Ca Granda, Milan

20246

University of Hamburg-Eppendorf, Hamburg

22100

Western Gailee Hospital - Nahariya, Nahariya

26500

University General Hospital of Patras, Pátrai

28100

Azienda Ospedllero Maggiore della Carita, Novara

31096

Rambam Medical Center, Haifa

31100

Cancer Institut Universitaire de Toulouse-Oncopole (iUCT), Toulouse

34461

Cancer and Blood Disease Center, Lecanto

37007

Hospital Universitario de Salamanca, Salamanca

37404

Associates in Oncology and Hematology, Chattanooga

40225

University of Dusseldorf, Düsseldorf

44093

CHU Nantes Hotel Dieu, Nantes

46026

Hospital Universitario y Politeecnico La Fe, Valencia

46202

Indiana University Health Melvin and Bren Simon Cancer Center, Indianapolis

48109

The University of Michigan - Comprehensive Cancer Center, Ann Arbor

48129

Universitatsklinikum Munster, Münster

49100

Rabin Medical Center, Petah Tikva

50009

Hospital Universitario Miguel Servet, Zaragoza

52621

The Chaim Sheba Medical Center, Ramat Gan

53226

Froedtert & Medical College of Wisconsin, Milwaukee

54511

Hopitaux de Brabois, Vandœuvre-lès-Nancy

55905

Mayo Clinic, Rochester

56068

Stiftungsklinikum Mittelrhein, Koblenz

56216

Azienda Ospedaliera Pisana Ospendale Santa Chiara - Main, Pisa

59037

Hopital Claude Huriez, Lille

60488

Krankenhaus Nordwest, Frankfurt am Main

60612

Rush University Medical Center, Chicago

66160

University of Kansas Cancer Center, Kansas City

68070

CH de Mulhouse, Hopital Emile Muller, Mulhouse

69120

Universitat Heidelberg, Heidelberg

72000

Clinique Victor Hugo - Centre Jean Bernard, Le Mans

75012

Hopital Saint-Antoine, Paris

75015

Groupe Hospitalier Necker - Enfants Malades, Paris

75246

Baylor Sammons Cancer Center, Dallas

76100

Kaplan Medical Center, Rehovot

76508

Scott and White Memorial Hospital, Temple

77030

The University of Texas, MD Anderson Cancer Center, Houston

79106

The Don & Sybil Harrington Cancer Center, Amarillo

80218

Colorado Blood Cancer Institute, Denver

81377

LMU Klinikum der Universitat, München

85259

Mayo Clinic, Scottsdale

91120

Hadassah Medical Center, Ein Kerem, Jerusalem

91505

Providence St. Joseph Medical Center, Burbank

92140

Hospital Antoine Beclere, Clamart

94305

Stanford University, Stanford

94503

St. Jude Hospital Yorba Linda dba; St. Joseph Heritage Healthcare, Santa Rosa

97080

Universitatsklinikum Wurzburg, Würzburg

98109

Fred Hutchinson Cancer Research Center, Seattle

115478

Federal State Budgetary Scientific Institution: N.N. Blokhin Russian Cancer Research Center, Moscow

125101

Moscow State Medical Institution Municipal City Clinical Hospital n.a. S.P. Botkin, Moscow

125167

Federal State Budget Institution: Hematology Research Center under MoH, Moscow

167904

State Medical Institution Komi Republican Oncological Center, Syktyvkar

191024

FSBI: Russian Research Institute of Hematology and Blood Transfusion under the Ferderal Agency for M&B, Saint Petersburg

197022

State Higher Educational Institution: St Petersburg State Medical University n.a.I.P Pavlov, Saint Petersburg

197101

SHEI: First St. Petersburg State Medical University N.a.I.P Pavlov under MoH, Clinic of Bone Marrow Transplant, Saint Petersburg

197341

Federal State Budget Institute: Federal Almalov Medical Research Centre under Ministry of Healthcare, Saint Petersburg

426039

First Republican Clinical Hospital under the Ministry of Healthcare of the Republic of Udmurtia, Izhevsk

700483

Regional Institute of Iasi, Iași

07601

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

75390-8565

UT Southwestern Medical Center at Dallas, Dallas

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 1Z2

University of Alberta, Cross Cancer Institute, Edmonton

V5Z 1M9

Vancouver General Hospital, Vancouver

R3E 0V9

Cancer Care Manitoba, Winnipeg

A1B 3V6

General Hospital, Health Sciences Centre, St. John's

M5G 2M9

Princess Margaret Hospital, Toronto

H3A 1A1

McGill University Health Center, Royal Victoria Hospital, Montreal

H3T 1E2

Sir Mortimer B. Davis - Jewish General Hospital, Montreal

625 00

University Hospital Brno, Department of Internal Medicine - Hematooncology, Brno

500 05

University Hospital Hradec Kralove, Hradec Králové

775 20

University Hospital Olomouc, Olomouc

100 34

University Hospital Kralovske Vinohrady - Prague, Prague

128 08

General University Hospital Prague, Prague

H-1097

St. Istvan and St. Laszlo Hospital of Budapest, Budapest

H-4032

University of Debrecen, Medical and Health Science Center, Debrecen

H-9032

Petz Aladar County Teaching Hospital, Győr

H-5700

Bekes County Pandy Kalman Hospital, Gyula

H-7400

Kaposi Mor County Teaching Hospital, Kaposvár

H-7624

University of Pecs, Pécs

H-6720

University of Szeged, Albert Szent-Gyorgi Clinical Center, Szeged

00144

Ospedale S. Eugenio, Roma

3015 CE

Erasmus MC, Department of Haematology, Rotterdam

80-952

University Clinical Centre, Department of Hematologii Transplantologii, Gdansk

66-400

Samodzielny Publ. Szp. Wojewodzki w Gorzow Wlkp., Gorzów Wielkopolski

40-027

Independent Public Teaching Hospital of Medical University of Silesia in Katowice, Katowice

93-510

Nicolaus Copernicus Memorial Provincial Specialist Hospital in Lodz, Lodz

16-400

Szpital Wojewwodzki im. dr Ludwika Rydygiera w Suwalkach, Suwałki

87-100

Nicolaus Copernicus Municipal Specialist Hospital, Torun

02-781

Maria Sklodowska-Curie Institute of Oncology, Warsaw

22-400

Zamojski Non-Public Hospital, Zamość

022328

"Fundeni Clinical Institute, Stefan Berceanu Center for Hematology and Bone Marrow Transplantation", Bucharest

030-171

Coltea Clinical Hospital, Bucharest

050098

Bucharest University Emergency Hospital, Bucharest

18 000

Clinical Center Nis, Clinic of Hematology, Niš

21 000

Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad

08916

Hospital Universitario Germans Trias i Pujol, Badalona

08036

Hospital Clinic I Provincial, Barcelona

SE-41345

Sahlgrenska Universitetssjukhuset, Gothenburg

SE-14186

Karolinska Universitetsjukhuset i Huddinge, Stockholm

SE-17176

Karolinska Universitetssjukhuset Solna, Hematologiskt Centrum, Stockholm

EC1A 7BE

St. Bartholomew's Hospital, London

NW3 2QG

Royal Free Hampstead, London

SW17 0QT

St. Georges Hospital, London

NG5 1PB

Nottingham University Hospitals (City Campus), Nottingham

SM2 5PT

Royal Marsden Hospital, Sutton

WV10 OQP

The Royal Wolverhampton Hospital NHS Trust, Wolverhampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY