Temozolomide and Radiation Therapy With or Without Cediranib Maleate in Treating Patients With Newly Diagnosed Glioblastoma

PHASE2CompletedINTERVENTIONAL
Enrollment

261

Participants

Timeline

Start Date

February 26, 2010

Primary Completion Date

December 6, 2015

Study Completion Date

May 20, 2022

Conditions
Adult GlioblastomaAdult Gliosarcoma
Interventions
RADIATION

3-Dimensional Conformal Radiation Therapy

Undergo 3-dimensional conformal radiotherapy

DRUG

Cediranib Maleate

Given PO

RADIATION

Intensity-Modulated Radiation Therapy

Undergo intensity-modulated radiation therapy

OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Placebo Administration

Given PO

DRUG

Temozolomide

Given PO

Trial Locations (105)

14642

University of Rochester, Rochester

15212

Allegheny General Hospital, Pittsburgh

15301

UPMC Washington Hospital Radiation Oncology, Washington

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

18015

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

18512

Northeast Radiation Oncology Center, Dunmore

19001

Jefferson Abington Hospital, Abington

19010

Bryn Mawr Hospital, Bryn Mawr

19096

Lankenau Medical Center, Wynnewood

19107

Thomas Jefferson University Hospital, Philadelphia

19301

Paoli Memorial Hospital, Paoli

19611

Reading Hospital, West Reading

19718

Christiana Care Health System-Christiana Hospital, Newark

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

22042

Inova Fairfax Hospital, Falls Church

26003

Wheeling Hospital/Schiffler Cancer Center, Wheeling

27103

Novant Health Forsyth Medical Center, Winston-Salem

27157

Wake Forest University Health Sciences, Winston-Salem

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

29303

Spartanburg Medical Center, Spartanburg

29425

Medical University of South Carolina, Charleston

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

32401

Bay Medical Center, Panama City

32803

AdventHealth Orlando, Orlando

35233

University of Alabama at Birmingham Cancer Center, Birmingham

35243

The Kirklin Clinic at Acton Road, Birmingham

40503

Baptist Health Lexington, Lexington

40536

University of Kentucky/Markey Cancer Center, Lexington

43210

Ohio State University Comprehensive Cancer Center, Columbus

44203

Summa Health System - Barberton Campus, Barberton

44266

University Hospitals Portage Medical Center, Ravenna

44304

Summa Health System - Akron Campus, Akron

44307

Cleveland Clinic Akron General, Akron

44460

UH Seidman Cancer Center at Salem Regional Medical Center, Salem

44691

Cancer Treatment Center, Wooster

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

46202

IU Health Methodist Hospital, Indianapolis

46804

Radiation Oncology Associates PC, Fort Wayne

46805

Parkview Hospital Randallia, Fort Wayne

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48060

Lake Huron Medical Center, Port Huron

48093

Saint John Macomb-Oakland Hospital, Warren

48106

Saint Joseph Mercy Hospital, Ann Arbor

48202

Henry Ford Hospital, Detroit

48236

Ascension Saint John Hospital, Detroit

48341

Saint Joseph Mercy Oakland, Pontiac

48532

Genesys Regional Medical Center-West Flint Campus, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48912

Sparrow Hospital, Lansing

49007

West Michigan Cancer Center, Kalamazoo

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center, Madison

54401

Aspirus Regional Cancer Center, Wausau

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

55433

Mercy Hospital, Coon Rapids

57701

Rapid City Regional Hospital, Rapid City

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

61637

OSF Saint Francis Medical Center, Peoria

61801

Carle Cancer Center, Urbana

63110

Washington University School of Medicine, St Louis

64111

Saint Luke's Hospital of Kansas City, Kansas City

66160

University of Kansas Cancer Center, Kansas City

66208

Kansas City NCI Community Oncology Research Program, Prairie Village

68114

Nebraska Methodist Hospital, Omaha

74136

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

78229

University of Texas Health Science Center at San Antonio, San Antonio

80524

Poudre Valley Hospital, Fort Collins

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84143

LDS Hospital, Salt Lake City

84403

McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center, Provo

84770

Saint George Regional Medical Center, St. George

85260

Arizona Oncology Services Foundation, Scottsdale

85719

Banner University Medical Center - Tucson, Tucson

91010

City of Hope Comprehensive Cancer Center, Duarte

92868

Saint Joseph Hospital - Orange, Orange

96813

Queen's Medical Center, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

The Cancer Center of Hawaii-Liliha, Honolulu

97015

Clackamas Radiation Oncology Center, Clackamas

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

98101

Virginia Mason Medical Center, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

98684

Compass Oncology Vancouver, Vancouver

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06050

The Hospital of Central Connecticut, New Britain

06520

Yale University, New Haven

04074

Maine Medical Center- Scarborough Campus, Scarborough

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Brigham and Women's Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

07871

Sparta Cancer Treatment Center, Sparta

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

77555-0565

University of Texas Medical Branch, Galveston

98122-4307

Swedish Medical Center-First Hill, Seattle

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

collaborator

Radiation Therapy Oncology Group

NETWORK

lead

National Cancer Institute (NCI)

NIH