1,675
Participants
Start Date
March 31, 2010
Primary Completion Date
October 31, 2013
Study Completion Date
October 31, 2013
Sarilumab
"Pharmaceutical form: solution for injection~Route of administration: subcutaneous"
Placebo (for sarilumab)
"Pharmaceutical form: solution for injection~Route of administration: subcutaneous"
Methotrexate
Same weekly dose as received prior to enrollment
Folic Acid
According to local standard
Investigational Site Number 356008, New Delhi
Investigational Site Number 158001, Taipei
Investigational Site Number 158002, Linkou District
Investigational Site Number 608001, Manila
Investigational Site Number 348006, Budapest
Investigational Site Number 348014, Budapest
Investigational Site Number 040002, Vienna
Investigational Site Number 710004, Kempton Park
Investigational Site Number 032010, Ramos Mejía
Investigational Site Number 032001, Rosario
Investigational Site Number 710001, Johannesburg
Investigational Site Number 036011, Sydney
Investigational Site Number 036003, Camperdown
Investigational Site Number 036006, St Leonards
Investigational Site Number 036010, Garran
Investigational Site Number 032009, Zárate
Investigational Site Number 554003, Tauranga
Investigational Site Number 036012, Fitzroy
Investigational Site Number 036004, Heidelberg West
Investigational Site Number 578006, Tønsberg
Investigational Site Number 036002, Malvern East
Investigational Site Number 036005, Clayton
Investigational Site Number 348011, Eger
Investigational Site Number 056003, Genk
Investigational Site Number 348005, Sátoraljaújhely
Investigational Site Number 032005, Buenos Aires
Investigational Site Number 032004, San Miguel de Tucumán
Investigational Site Number 056001, Liège
Investigational Site Number 710003, Durban
Investigational Site Number 036009, Herston
Investigational Site Number 348003, Debrecen
Investigational Site Number 348010, Debrecen
Investigational Site Number 710002, Durban
Investigational Site Number 036001, Maroochydore
Investigational Site Number 578004, Kristiansand
Investigational Site Number 036007, Woodville
Investigational Site Number 608003, Cebu City
Investigational Site Number 036014, Victoria Park
Investigational Site Number 484003, Mexico City
Investigational Site Number 710011, Cape Town
Investigational Site Number 710007, Cape Town
Investigational Site Number 710010, Stellenbosch
Investigational Site Number 710009, Cape Town
Investigational Site Number 554004, Christchurch
Investigational Site Number 040001, Graz
Investigational Site Number 348004, Veszprém
Investigational Site Number 348013, Gy?r
Investigational Site Number 840056, New York
Investigational Site Number 233001, Tallinn
Investigational Site Number 764001, Bangkok
Investigational Site Number 764003, Bangkok
Investigational Site Number 300001, Athens
Investigational Site Number 484001, Mexico City
Investigational Site Number 276007, Berlin
Investigational Site Number 276008, Berlin
Investigational Site Number 203001, Prague
Investigational Site Number 233002, Tallinn
Investigational Site Number 724009, A Coruña
Investigational Site Number 724012, Santiago de Compostela
Investigational Site Number 840009, Duncansville
Investigational Site Number 840010, Bethlehem
Investigational Site Number 840062, Reading
Investigational Site Number 840013, Wheaton
Investigational Site Number 840073, Cumberland
Investigational Site Number 840055, Frederick
Investigational Site Number 276005, Hamburg
Investigational Site Number 276013, Hamburg
Investigational Site Number 246003, Pori
Investigational Site Number 840068, Hickory
Investigational Site Number 840058, Columbia
Investigational Site Number 840016, North Charleston
Investigational Site Number 840028, Decatur
Investigational Site Number 840027, Marietta
Investigational Site Number 840003, Atlanta
Investigational Site Number 458001, Ipoh
Investigational Site Number 276006, Hildesheim
Investigational Site Number 840041, Jacksonville
Investigational Site Number 840006, Orlando
Investigational Site Number 840048, Miami
Investigational Site Number 840067, Jupiter
Investigational Site Number 840060, Sarasota
Investigational Site Number 484008, Durango
Investigational Site Number 840063, Palm Harbor
Investigational Site Number 840050, Dunedin
Investigational Site Number 840004, Birmingham
Investigational Site Number 792001, Izmir
Investigational Site Number 840070, Anniston
Investigational Site Number 840025, Jackson
Investigational Site Number 840015, Lexington
Investigational Site Number 724007, Seville
Investigational Site Number 840044, Toledo
Investigational Site Number 276001, Herne
Investigational Site Number 484002, Guadalajara
Investigational Site Number 804003, Dnipropetrovsk
Investigational Site Number 484007, Metepec
Investigational Site Number 276003, Frankfurt am Main
Investigational Site Number 840046, Chicago
Investigational Site Number 804010, Kharkiv
Investigational Site Number 840066, St Louis
Investigational Site Number 203005, Brno
Investigational Site Number 484005, Monterrey
Investigational Site Number 840071, Omaha
Investigational Site Number 203002, Uherské Hradiště
Investigational Site Number 276012, Heidelberg
Investigational Site Number 804009, Zaporizhzhia
Investigational Site Number 300002, Heraklion
Investigational Site Number 840002, Oklahoma City
Investigational Site Number 840011, Tulsa
Investigational Site Number 840065, Tulsa
Investigational Site Number 203004, Hlučín
Investigational Site Number 840074, Mesquite
Investigational Site Number 840001, Dallas
Investigational Site Number 840022, Dallas
Investigational Site Number 840012, Dallas
Investigational Site Number 840020, Houston
Investigational Site Number 804005, Lviv
Investigational Site Number 840069, Lubbock
Investigational Site Number 804002, Donetsk
Investigational Site Number 840018, Idaho Falls
Investigational Site Number 840072, Gilbert
Investigational Site Number 840029, Beverly Hills
Investigational Site Number 276004, Erlangen
Investigational Site Number 840049, Upland
Investigational Site Number 840007, Palm Desert
Investigational Site Number 458002, Kuching
Investigational Site Number 840008, San Francisco
Investigational Site Number 840021, Santa Maria
Investigational Site Number 804006, Simferopol
Investigational Site Number 484004, Mérida
Investigational Site Number 484009, Mérida
Investigational Site Number 840061, Tacoma
Investigational Site Number 643004, Moscow
Investigational Site Number 643020, Moscow
Investigational Site Number 643001, Moscow
Investigational Site Number 643002, Moscow
Investigational Site Number 643012, Moscow
Investigational Site Number 356002, New Delhi
Investigational Site Number 643007, Saint Petersburg
Investigational Site Number 643008, Saint Petersburg
Investigational Site Number 643014, Saint Petersburg
Investigational Site Number 112002, Minsk
Investigational Site Number 112001, Minsk
Investigational Site Number 356011, Lucknow
Investigational Site Number 356013, Lucknow
Investigational Site Number 356015, Ahmedabad
Investigational Site Number 643016, Ryazan
Investigational Site Number 356010, Mumbai
Investigational Site Number 356004, Mumbai
Investigational Site Number 642003, Bucharest
Investigational Site Number 643011, Saratov
Investigational Site Number 643010, Samara
Investigational Site Number 643013, Ufa
Investigational Site Number 356012, Hyderabad
Investigational Site Number 356005, Hyderabad
Investigational Site Number 356007, Bangalore
Investigational Site Number 356003, Chennai
Investigational Site Number 643009, Novosibirsk
Investigational Site Number 643017, Kemerovo
Investigational Site Number 643006, Kemerovo
Investigational Site Number 642005, Galati
Investigational Site Number 642006, Brăila
Investigational Site Number 152007, Viña del Mar
Investigational Site Number 152014, Talca
Investigational Site Number 152012, Santiago
Investigational Site Number 032007, Buenos Aires
Investigational Site Number 032008, Buenos Aires
Investigational Site Number 032003, Córdoba
Investigational Site Number 152005, Osorno
Investigational Site Number 152010, Port Montt
Investigational Site Number 152001, Santiago
Investigational Site Number 152002, Santiago
Investigational Site Number 152008, Santiago
Investigational Site Number 152009, Santiago
Investigational Site Number 152011, Santiago
Investigational Site Number 152013, Santiago
Investigational Site Number 152004, Valdivia
Investigational Site Number 152006, Viña del Mar
Investigational Site Number 170004, Barranquilla
Investigational Site Number 170001, Bogotá
Investigational Site Number 170003, Bogotá
Investigational Site Number 170006, Bogotá
Investigational Site Number 170008, Bogotá
Investigational Site Number 170007, Bucaramanga
Investigational Site Number 170009, Bucaramanga
Investigational Site Number 170002, Medellín
Investigational Site Number 818001, Cairo
Investigational Site Number 818002, Cairo
Investigational Site Number 458003, Putrajaya
Investigational Site Number 554002, Rotorua
Investigational Site Number 554001, Timaru
Investigational Site Number 608002, Manila
Investigational Site Number 620002, Lisbon
Investigational Site Number 642004, Bucharest
Investigational Site Number 642010, Bucharest
Investigational Site Number 642008, Ploieşti
Investigational Site Number 710008, Pretoria
Investigational Site Number 410001, Incheon
Investigational Site Number 410002, Seoul
Investigational Site Number 792005, Ankara
Investigational Site Number 032006, Caba
Investigational Site Number 032002, Córdoba
Investigational Site Number 032012, Mar del Plata
Investigational Site Number 032011, Quilmes
Investigational Site Number 076008, Campinas
Investigational Site Number 076012, Campinas
Investigational Site Number 076001, Curitiba
Investigational Site Number 076006, Goiânia
Investigational Site Number 076010, Juiz de Fora
Investigational Site Number 076004, Porto Alegre
Investigational Site Number 076005, Rio de Janeiro
Investigational Site Number 076011, Salvador
Investigational Site Number 076002, São Paulo
Investigational Site Number 076003, São Paulo
Investigational Site Number 076013, Vitória
Investigational Site Number 124004, Burlington
Investigational Site Number 124003, Mississauga
Investigational Site Number 124008, Newmarket
Investigational Site Number 124002, St. Catharines
Investigational Site Number 124005, Toronto
Investigational Site Number 124001, Toronto
Investigational Site Number 124012, Winnipeg
Investigational Site Number 246001, Helsinki
Investigational Site Number 246002, Hyvinkää
Investigational Site Number 276015, Halle
Investigational Site Number 300003, Thessaloniki
Investigational Site Number 348015, Szombathely
Investigational Site Number 356001, Maharashtra
Investigational Site Number 440001, Kaunas
Investigational Site Number 440002, Vilnius
Investigational Site Number 528002, Heerlen
Investigational Site Number 616002, Bialystok
Investigational Site Number 616003, Bialystok
Investigational Site Number 616001, Krakow
Investigational Site Number 616005, Lublin
Investigational Site Number 616006, Torun
Investigational Site Number 616004, Warsaw
Investigational Site Number 616012, Wroclaw
Investigational Site Number 620003, Aveiro
Investigational Site Number 620001, Lisbon
Investigational Site Number 642001, Bucharest
Investigational Site Number 642002, Bucharest
Investigational Site Number 710005, Pretoria
Investigational Site Number 710006, Pretoria
Investigational Site Number 410014, Anyang
Investigational Site Number 410006, Busan
Investigational Site Number 410004, Daegu
Investigational Site Number 410013, Daegu
Investigational Site Number 410005, Daejeon
Investigational Site Number 410010, Gwangju
Investigational Site Number 410009, Incheon
Investigational Site Number 410011, Jeonju
Investigational Site Number 410007, Seoul
Investigational Site Number 410012, Seoul
Investigational Site Number 410003, Seoul
Investigational Site Number 410008, Suwon
Investigational Site Number 724010, Barcelona
Investigational Site Number 724011, Sabadell
Investigational Site Number 792003, Adana
Investigational Site Number 792002, Ankara
Investigational Site Number 792004, Antalya
Investigational Site Number 804008, Kyiv
Investigational Site Number 804004, Kyiv
Lead Sponsor
Regeneron Pharmaceuticals
INDUSTRY
Sanofi
INDUSTRY