NCT01056614 - Fludarabine Phosphate, Busulfan, and Anti-Thymocyte Globulin Followed By Donor Peripheral Blood Stem Cell Transplant, Tacrolimus, and Methotrexate in Treating Patients With Myeloid Malignancies | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

September 30, 2004

Primary Completion Date

August 31, 2005

Study Completion Date

April 30, 2016

Conditions

Accelerated Phase Chronic Myelogenous LeukemiaAdult Acute Myeloid Leukemia in RemissionAdult Acute Myeloid Leukemia With 11q23 (MLL) AbnormalitiesAdult Acute Myeloid Leukemia With Del(5q)Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)Blastic Phase Chronic Myelogenous LeukemiaChildhood Acute Myeloid Leukemia in RemissionChildhood Chronic Myelogenous LeukemiaChildhood Myelodysplastic SyndromesChronic Phase Chronic Myelogenous Leukemiade Novo Myelodysplastic SyndromesHematopoietic/Lymphoid CancerMyelodysplastic/Myeloproliferative Neoplasm, UnclassifiablePreviously Treated Myelodysplastic SyndromesRecurrent Adult Acute Myeloid LeukemiaRecurrent Childhood Acute Myeloid LeukemiaRelapsing Chronic Myelogenous Leukemia

Interventions

DRUG

fludarabine phosphate

Given IV

DRUG

busulfan

Given IV

BIOLOGICAL

anti-thymocyte globulin

Given IV

DRUG

tacrolimus

Given IV and orally

DRUG

methotrexate

Given IV

PROCEDURE

peripheral blood stem cell transplantation

Undergo allogeneic PBSC transplant

PROCEDURE

allogeneic hematopoietic stem cell transplantation

Undergo allogeneic PBSC transplant

OTHER

laboratory biomarker analysis

Correlative studies

Trial Locations (1)

98109

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle

All Listed Sponsors

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

National Cancer Institute (NCI)

NIH

lead

Fred Hutchinson Cancer Center

OTHER