Impact of Diabetes on Left Ventricular Remodeling

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

July 31, 2005

Primary Completion Date

November 30, 2010

Study Completion Date

November 30, 2010

Conditions
Diabetes
Interventions
DRUG

Ramipril

The starting dose of Ramipril will be 2.5 mg once daily and rapidly titrated upward to 5 mg once daily after 5 days if systolic blood pressure is greater than 100 mmHg. After one month the patient will return to clinic for blood pressure check and will be titrated up to 10 mg once daily.

DRUG

Candesartan cilexetil

The starting dose of Candesartan cilexetil will be 4 mg or 8 mg once daily and doubled every 2 weeks, if systolic blood pressure is greater than 100 mmHg, to a maximum dose of 32 mg once daily. After one month the patient will return to clinic for blood pressure check and will be titrated up to 32 mg once daily.

DRUG

Allopurinol

The starting dose of Allopurinol is 300 mg daily.

Trial Locations (1)

35294-2180

University of Alabama at Birmingham, Birmingham

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

AstraZeneca

INDUSTRY

lead

University of Alabama at Birmingham

OTHER