Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers

PHASE4CompletedINTERVENTIONAL
Enrollment

197

Participants

Timeline

Start Date

June 30, 2005

Primary Completion Date

January 31, 2013

Study Completion Date

January 31, 2013

Conditions
Nicotine Dependence
Interventions
DRUG

Bupropion SR

150 encapsulated pill,3 days 1x/day then 56/day for 2x/day, then 3 day 1x/day ramp-down.

DRUG

Nicotine Patch

Nicotine patch beginning 1st day cessation: 21 mg/24 days, 14 mg/14 days, 7 mg/7 days

DRUG

Placebo Patch and Placebo Pill

150 encapsulated placebo pill,3 days 1x/day then 56/day for 2x/day, then 3 day 1x/day ramp-down. Placebo patch beginning 1st day cessation: 21 mg/24 days, 14 mg/14 days, 7 mg/7 days. The placebo patches were given beginning 1st day cessation: 21 mg size (but actually placebo)/24 days, 14 mg size (actually placebo)/ 14 mg size (actually placebo) 14 days/, 7 mg size (actually placebo)/7 days

Trial Locations (1)

62901-6502

Southern Illinois University, Carbondale

All Listed Sponsors
collaborator

National Institute on Drug Abuse (NIDA)

NIH

lead

Southern Illinois University Carbondale

OTHER

NCT01048944 - Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers | Biotech Hunter | Biotech Hunter