Comparing The Effectiveness And Safety Of 2 Doses Of An Experimental Drug, CP-690,550, To Methotrexate (MTX) In Patients With Rheumatoid Arthritis Who Have Not Previously Received MTX

PHASE3CompletedINTERVENTIONAL
Enrollment

956

Participants

Timeline

Start Date

January 31, 2010

Primary Completion Date

March 31, 2013

Study Completion Date

March 31, 2013

Conditions
Arthritis, Rheumatoid
Interventions
DRUG

CP-690,550

Oral tablets administered at a dose of 5 mg BID for 24 months

DRUG

CP-690,550

Oral tablets administered at a dose of 10 mg BID for 24 months

DRUG

Disease-modifying antirheumatic drug

Oral capsules,administered as 10 mg per week for 4 weeks titrated to 15 mg per week for 4 weeks, then titrated to 20 mg week for 24 months

Trial Locations (176)

407

Taichung Veterans General Hospital, Taichung

704

National Cheng Kung University Hospital, Tainan City

807

Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung City

1003

Rayuma Klinik, OPD Department, Jose R. Reyes Memorial Medical Center, Manila

1027

Revita Reumatologiai Rendelo, Budapest

1606

MBAL na Voennomeditsinska Akademia - Sofia, Klinika po Revmatologia i Kardiologia, Sofia

1612

MBAL Sveti Ivan Rilski Sofia; Klinika po Revmatologia, Sofia

1640

Centre for Clinical Research and Effective Practice (CCREP Middlemore Hospital, Otahuhu

1709

"DKTs Sveta Anna, Sofia; Konsultativen kabinet po Revmatologia", Sofia

3145

Emeritus Research, Malvern East

3204

Ryburns Building, Waikato Hospital, Hamilton

3400

Mozgasszervi Rehabilitacios Kozpont, Reumatologiai szakrendeles, Mezőkövesd

4000

Revmatologichno Otdelenie, MBAL - Plovdiv, Plovdiv

4558

Rheumatology Research Unit Sunshine Coast, Maroochydore

5000

"MOBAL D-r Stefan Cherkezov AD, Revmokardiologichno otdelenie s intenziven sektor", Veliko Tarnovo

5011

The Queen Elizabeth Hospital, Department of Rheumatology, Woodville

6000

Chong Hua Hospital, Cebu City

7002

MBAL-Ruse, AD, IV Terapevtichno i kardiologichno otdelenie, Rousse

7910

Timaru Hospital, Clinical Trials Unit, Timaru

8000

Brokenshire Integrated Health Ministries, Inc. Brokenshire Memorial Hospital, Davao City

8022

The Canterbury Geriatric Medical Research Trust, c/- The Princess Margaret Hospital, Christchurch

8230

Drug Research Center Kft. Reumatologiai Szakrendeles, Balatonfüred

9000

Universitair Ziekenhuis Gent - Reumatologie, Ghent

10400

Rheumatology Unit, Department of Internal Medicine, Phramongkutklao Hospital, Phayathai

Rheumatology Unit, Department of Internal Medicine, Rajavithi Hospital, Bangkok

10700

Siriraj Hospital, Mahidol University, Bangkok

12206

The Center for Rheumatology, Albany

14059

Schlosspark-Klinik, Berlin

14618

AAIR Research Center, Rochester

15705

Hospital Nuestra Señora de La Esperanza, Santiago de Compostela

16635

Altoona Center for Clinical Research, Duncansville

19610

Clinical Research Center of Reading, LLP, Wyomissing

20902

The Center for Rheumatology and Bone Research, Wheaton

21018

Vinnitsa Regional Clinical Hospital n.a. M.I. Pirogov, Vinnitsa

22081

Schoen Klinik Hamburg-Eilbek, Abt. Rheumatologie und Klin. Immunologie, Hamburg

26301

Mountain State Clinical Research, Clarksburg

United Hospital Center (Imaging Only), Clarksburg

27000

Unidad de Enfermedades Reumaticas y Cronico Degenerativas SC, Torreón

28007

Hospital General Universitario Gregorio Maranon, Madrid

28601

PMG Research of Hickory, LLC, Hickory

28602

PMG Research of Hickory, LLC, Hickory

29009

Hospital Civil. Hospital Regional Universitario Carlos Haya, Málaga

29425

Medical University of South Carolina - Rheumatology, Charleston

Medical University of South Carolina Investigational Drug Services, Charleston

Medical University of South Carolina, Charleston

32607

Southeastern Arthritis Center, Gainesville

Southeastern Imaging and Diagnostics, Gainesville

Southeastern Integrated Medical, PL dba Florida Medical Research, Gainesville

33173

Center for Arthritis and Rheumatic Diseases, Miami

33321

West Broward Rheumatology Associates, Inc., Tamarac

33613

Bernard F. Germain, MD, Tampa

33614

Burnette & Silverfield, MDS PLC, Tampa

34239

Sarasota Arthritis Research Center, Sarasota

38305

Arthritis Clinic, Jackson

West Tennessee Research Institute, Jackson

40882

Rheumaforschung - Studienambulanz Dr. Wassenberg, Ratingen

41009

Hospital Universitario Virgen Macarena, Seville

44158

Instituto Jaliscience de Investigación Clínica SA de CV, Guadalajara

44620

Unidad de Investigacion en Enfermedades Cronico Degenerativas, Guadalajara

46150

Sunway Medical Centre, Petaling Jaya

46227

Diagnostic Rheumatology and Research, PC, Indianapolis

48013

Hospital de Basurto, Bilbao

48431

Schwerpunktpraxis fuer Rheumatologie, Rheine

50005

Fakultni nemocnice Hradec Kralove, Hradec Králové

52002

Medical Associates Clinic, PC, Dubuque

52064

Privat-Praxis, Rheumatologie (P515), Aachen

61500

Revmacentrum MUDr. Mostera, s.r.o., Brno - Zidenice

62500

Fakultni nemocnice Brno, Brno

64020

Hospital Universitario Jose Eleuterio Gonzalez, Monterrey

65026

"Municipal Establishment City Clinical Hospital #9 n.a. O.I. Minakov, Department of Rheumatology", Odesa

68516

Physician Research Collaboration, LLC, Lincoln

70115

Louisiana State University Health Sciences, New Orleans

70300

Hospital Tuanku Ja'afar, Seremban

70800

Revmatologicka ambulance, Ostrava-Poruba

72205

Little Rock Diagnostic Clinic, Little Rock

73112

Lynn Health Science Institute, Oklahoma City

75231

Metroplex Clinical Research Center, Dallas

76107

University of North Texas Health Science Center at Fort Worth, Fort Worth

78705

Austin Rheumatology Research, Austin

79011

Municipal City Clinical Hospital #4, Department of Rheumatology, Lviv

81108

Reumatolog s.r.o., Bratislava

85704

Catalina Pointe Clinical Research, Inc., Tucson

90033

Keck Hospital of USC, Lower Level Pharmacy, Los Angeles

Keck Hospital of USC, Los Angeles

USC Keck School of Medicine, Los Angeles

90095

University of California Los Angeles (UCLA), Los Angeles

90429

Arztpraxis, Internist - Rheumatologie, Nuremberg

91054

Studienambulanz, Medizinische Klinik 3 Universitaetsklinikum Erlangen, Erlangen

92901

AAGS, s.r.o. , nestatne zdravotnicke zariadenie, Dunajská Streda

93586

Sarawak General Hospital, Kuching

94001

Reumatologicka ambulancia, Ecclesia, s.r.o., Nové Zámky

95017

"CRI Clinical Territorial Medical Association University Clinic, Department of Rheumatology", Simferopol

98101

Investigational Drug Service, Seattle

Virginia Mason Medical Center, Seattle

190068

State Health Institution City Hospital # 25, City Rheumatology Center of St. Petersburg, Saint Petersburg

194291

Clinical Hospital #122 named after L.G. Sokolov of the Federal Medical-Biological Agency, Saint Petersburg

197341

Almazov Federal Heart, Blood and Endocrinology Centre, Saint Petersburg

197706

State Healthcare Institution City Hospital # 40 of Administrative Health Resort District, Saint Petersburg

198260

St. Petersburg State Institution of Healthcare Consultative-diagnostic Center #85, Saint Petersburg

214019

Smolensk State Medical Academy, Clinical Research Centre of Diagnostic Medicine and Drugs, Smolensk

380009

Rheumatic Disease Clinic, Ahmedabad

380015

Shalby Hospital, Ahmedabad

500003

Department of Rheumatology, Secunderabad

620102

State Healthcare Institution, Yekaterinburg

620109

"Ltd. Medical Association Novaya Bolnitsa (X-Ray Only)", Yekaterinburg

620149

State Educational Institution of Higher Professional Education, Yekaterinburg

630055

Federal State Institution named after Academician E.N. Meshalkin, Novosibirsk State Research, Novosibirsk

630117

Scientific Research Institute of Clinical and Experimental Lymphology of the Siberian Branch of RAMS, Novosibirsk

634063

Regional State Healthcare Institution of Tomsk Regional Clinical Hospital, Tomsk

650099

State Healthcare Institution Regional Clinical Hospital for War Veterans, Kemerovo

656024

State Healthcare Institution Regional Clinical Hospital, Barnaul

2570017

Estudios Clinicos V Region, Viña del Mar

2841959

Hospital Regional de Rancagua, Rancagua

4790928

Consulta Privada Dra. Lucia Ponce, Temuco

7501126

Centro de Estudios Reumatologicos, Santiago

7510186

Consulta Privada Dra. Marta Aliste, Santiago

92037-0943

University of California San Diego Perlman Ambulatory Clinic, La Jolla

92093 0943

University of California San Diego Center for Innovative Therapy, La Jolla

01605

Clinical Pharmacology Study Group, Worcester

C1015ABO

OMI - Organización Médica de Investigación, Buenos Aires

C1034ACO

Saint Dennis Medical Group S.A., Buenos Aires

C1428DZF

Consultorios Reumatológicos Pampa, Buenos Aires

74110-120

CIP - Centro Internacional de Pesquisas, Goiânia

74115-030

Clinica de Raios X Nabyh Salum S/S - Clinica Sao Matheus, Goiânia

80060-240

Centro de Estudos em Terapias Inovadoras, Curitiba

90610-000

Hospital Sao Lucas da PUCRS, Porto Alegre

04266-010

CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda, São Paulo

22271-100

CCBR Brasil Centro de Pesquisas e Analises Clinicas Ltda, Rio de Janeiro

T5M 0H4

Rheumatology Research Associates Ltd., Edmonton

V8V 3P9

PerCuro Clinical Research Ltd., Victoria

R3A 1M3

Manitoba Clinic, Winnipeg

L7L 0B7

Burlington Rheumatology and Osteoporosis Clinic, Burlington

L8N 1Y2

Dr. William G. Bensen Medicine Professional Corporation, Hamilton

Office of Dr. Fernando Bianchi, Hamilton

L8N 2B6

MAC Research Inc., Hamilton

N2M 5N6

KW Musculoskeletal Research Inc., Kitchener

K1H 1A2

Rheumatology Research Associates, Ottawa

L2N 7E4

Niagara Peninsula Arthritis Centre, St. Catharines

N8X 1K7

Windsor Radiological Associates, Windsor

N8X 5A6

Clinical Research and Arthritis Centre, Windsor

Unknown

Centro de Reumatologia y Ortopedia, Barranquilla

Servimed E.U, Bucaramanga

0000

Centro Integral de Reumatologia e Inmunologia CIREI, Bogota

00000

Centro de Reumatología y Osteoporosis, Cartago, Cartago

Hospital Cima San Jose, San José

Patricia Alvarez Site, Santo Domingo

128 50

Revmatologicky ustav, Prague

140 00

Revmatologicka ambulance, Prague

06108

Schwerpunktpraxis Rheumatologie FAE Innere Medizin, Halle

H-1036

Synexus Magyarorszag Kft., Budapest

H-5000

MAV Korhaz es Rendelointezet, Szolnok

500 004

Mahavir Hospital & Research Center, Hyderabad

560 054

Shirdi Sai Hospital, Bangalore

411 001

Arthritis Research and Care Foundation, Pune

Jehangir Clinical Development Centre Pvt. Ltd., Pune

C-02

Hospital Nacional IV Alberto Sabogal Sologuren, Callao

L 27

Clinica Anglo Americana, Lima

L-27

Centro Medico Corpac, Lima

Instituto Peruano del Hueso y la Articulacion SAC-Privado-Lima/Centro de Investigacion IPHAR, Lima

81-367

Przychodnia Medyczna Lekarskiej Spoldzielni Pracy, Gdynia

81-384

Centrum Leczenia Chorob Cywilizacyjnych Sp. z.o.o. SKA Oddzial Gdynia, Gdynia

40-748

Centrum Leczenia Chorob Cywilizacyjnych Sp. z o.o. SKA Oddzial Katowice, Katowice

01-192

Synexus SCM Sp. z o.o. Oddzial Warszawa, Warsaw

02-118

Rheuma Medicus - Specjalistyczne Centrum Reumatologii i Osteoporozy, Warsaw

00716

Ponce School of Medicine, Ponce

00717-1321

Edificio Parra, Ponce

921 12

Narodny ustav reumatickych chorob, Piešťany

010 01

Nestatna reumatologicka ambulancia, Žilina

110-744

Seoul National University Hospital, Rheumatology, Internal Medicine, Seoul

120-752

Yonsei University College of Medicine, Severance Hospital, Rheumatology, Internal Medicine, Seoul

138-736

Asan Medical Center, Rheumatology, Internal Medicine, Seoul

205 02

Skanes Universitetssjukhus i Malmo, Malmo

851 86

Sundsvalls sjukhus- Medicinkliniken, Sundsvall

751 85

Akademiska sjukhuset, Reumatologmottagningen, Uppsala

04053

"State Institution Republican Clinical Hospital of the Ministry of Health of Ukraine", Kyiv

04114

"State Institution Republican Clinical Hospital of the Ministry of Health of Ukraine", Kyiv

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY