A Study of Lenalidomide Versus Placebo in Subjects With Transfusion Dependent Anemia in Lower Risk Myelodysplastic Syndrome (MDS) Without Del 5q

PHASE3CompletedINTERVENTIONAL
Enrollment

239

Participants

Timeline

Start Date

January 26, 2010

Primary Completion Date

March 17, 2013

Study Completion Date

May 9, 2018

Conditions
Anemia
Interventions
DRUG

Lenalidomide

One 10 mg Lenalidomide capsule + 2 placebo capsules or (3 placebo capsules) once daily for subjects with a creatinine clearance ≥ 60 mL/min. Alternatively-one 5 mg Lenalidomide capsule + 2 placebo capsules (or 3 placebo capsules) once daily for subjects with a creatinine clearance between 40 and 60 mL/min. Subjects may take study drug for at least 168 days unless there are intolerable side effects or disease progresses. Subjects may continue study drug beyond 168 days if they have an erythroid response (increase in their hemoglobin levels and fewer transfusions administered than before starting study drug)

OTHER

Placebo

3 placebo capsules once daily. Subjects may take study drug for at least 168 days unless there are intolerable side effects or disease progresses. Subjects may continue study drug beyond 168 days if they have an erythroid response (increase in their hemoglobin levels and fewer transfusions administered than before starting study drug)

Trial Locations (99)

1140

Wiener Gebietskrankenkasse-Hanusch-Krankenhaus, Vienna

1200

Cliniques Universitaires Saint-Luc, Brussels

1307

BAG Freiberg-Richter, Jacobash, Illmer, Wolf, Dresden

2500

Wollongong Hospital, Wollongong

2650

Universitair Ziekenhuis Antwerpen, Edegem

4000

Centre Hospitalier Universitaire de Liege, Liège

4020

Krankenhaus der Elisabethinen Linz, I Interne Abteilung, Linz

4102

Princess Alexandra Hospital, Woolloongabba

4600

Klinikum Wels-Grieskirchen GmbH, Weis

5020

Universitatsklinik fur Innere Medizin Salzburg, Salzburg

5530

Cliniques Universitaires UCL de Mont-Godine, Namur

6000

Grand Hopital de Charleroi, Charleroi

6020

Medizinische Universitat Innsbruck, Innsbruck

7000

Center Hospitalier Universitaire Ambroise Pare, Mons

7198

Hospital Son Llatzer, Palma de Mallorca

8000

AZ St-Jan Brugge Oostende AV, Bruges

10032

Columbia University Medical Center, New York

10043

AOU San Luigi Gonzaga, Orbassano

12808

Vseobecna Fakultni Nemocnice v Praze, Prague

13273

Institut Paoli-Calmettes, Marseille

15100

Az. Osp. SS.Antonio e Biagio - SC Ematologia, Alessandria

28046

Hospital Universitario La Paz, Madrid

29010

Hospital Universitario Virgen de la Victoria, Málaga

30625

Medizinische Hochschule Hannover, Hanover

33100

Policlinico Univeristario di Udine, Udine

34390

Istanbul Universitesi Istanbul, Istanbul

35340

Dokuz Eylul Universitesi Tip Faiultesi, Izimir

37007

Hospital Universitario de Salamanca, Salamanca

38700

Hopital A. Michallon, La Tronche

40138

A.O.U. di Bologna Policlinico S.Orsola-Malpighi, Bologna

40211

Universitätsklinikum Düsseldorf, Düesseldorf

40479

Marien Hospital, Düsseldorf

41013

Hospital Universitario Virgen Del Rocio, Seville

46009

Hospital Universitario La Fe, Valencia

47166

Sankt Johannes Hospital Duisburg, Duisberg

49033

CHU d'Angers, Angers

49100

Rabin Medical Center, Petah Tikva

50139

Azienda Ospedaliero-Universitaria Careggi, Florence

50924

Universitat zu Koln, Cologne

52621

The Chaim Sheba Medical Center, Tel Litwinsky

53226

Medical College of Wisconsin, Milwaukee

59037

CHRU de Lille-Hopital Claude Huriez Service des Maladies du Sang, Lille

62801

Southern Illinois Hematology Oncology, Centralia

64239

Tel-Aviv Sourasky Medical Center, Tel Aviv

68135

Universitatsklinikum Mannheim, Mannheim

69120

Klinikum Mannheim der Universitat Heidelberg, Heidelberg

75679

Groupe hospitalier Cochin Saint-Vincent de Paul, Paris

77030

University of Texas MD Anderson Cancer Center, Houston

77520

Fakultni nemocnice Olomouc, Olomouc

80131

Azienda Ospedaliera Cardarelli, Naples

81675

TU München - Klinikum rechts der Isar, München

90095

University of California at Los Angeles, Los Angeles

93009

Hopital Avicenne, Bobigny

03756

Dartmouth Hitchcock Medical Center Norris Cotton Cancer Center, Lebanon

07601

Hackensack University Medical Center, Hackensack

5000 SA

Royal Adelaide Hospital Institute of Medical and Veterinary Science, Adelaide

T2N 4N2

Tom Baker Cancer Center, Calgary

T6G 2B7

University of Alberta Hospital, Edmonton

R3E 0V9

Cancer Care Manitoba, Winnepeg

M4N 3M5

Sunnybrook Regional Cancer Center, Toronto

M5G 2M9

Princess Margaret Hospital and University of Toronto, Toronto

H1T 2M4

Maisonneuve Rosemont, Montreal

H2W 1S6

McGill University, Dept. Oncology Clinical Research Program, Montreal

H4J 1C5

Hopital du Sacre-Coeur de Montreal, Montreal

625 00

Fakultni nemocnice Brno, Brno

128 20

Ustav hematologie a krevni transfuze, Prague

09100

P.O. Ospedale Roberto Binaghi (UNI CA/ASL 8), Cagliari

09121

Azienda Ospedaliero-Universitaria di Cagliari, Cagliari

Unknown

IRCCS Centro di Riferimento Oncologico di Basilicata di Rionero in Vulture, Rionero in Vulture

Hiroshima University Hospital, Hiroshima

Kanazawa University Hospital, Kanazawa

Nagasaki Unversity Hospital, Nagasaki

Osaka Red Cross Hospital, Osaka

Jichi Medical University Hospital, Shimotsuke

Kanto Medical Center NTT EC, Shinagawa City

00133

Azienda Ospedaliera Universitaria Policlinico Tor Vergata, Roma

00161

Azienda Policlinico Umberto I, Universita La Sapienzadi Roma, Roma

00168

Policlinico Agostino Gemelli - Istituto di Ematologia, Roma

259-1193

Tokai University School of Medicine, Isehara City, Kanagawa

296-8602

Kameda General Hospital, Kamogawa

460-0001

National Hospital Organization Nagoya Medical Center, Nagoya

980-8574

Tohoku University Hospital, Sendai

150-8935

Japanese Red Cross Medical Center, Shibuya City

80-119

Katedra i Klinika Hematologii i Transplantacji Szpiku - SLASKIEGO UNIWERSYTETU MEDYCZNEGO, Gdansk

93-510

Uniwersytet Medyczny w Lodzi, Lodz

02-776

Instytut Hematologii i Transfuzjologii, Klinika Hematologii, Warsaw

3000-075

Hospitais da Universidade de Coimbra, Coimbra

1090-023

Instituto Portugues de Oncologia de Lisboa, Lisbon

4099-001

Hospital Geral de Santo Antonio, Porto

08036

Hospital Clinic Provincial de Barcelona, Barcelona

06500

Gazi Universitesi Tip Fakltesi, Ankara

07503

Akdeniz Universitesi Tip Fakultesi, Antalya

BH7 7DW

Royal Bournemouth Hospital, Bournemouth

CF14 4XN

University Hospital of Wales, Cardiff

LS9 7TF

Saint James University Hospital, Leeds

EC1A 7BE

Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London

SE5 9RS

King's College Hospital, London

M20 4BX

Christie Hospital, Manchester

OX3 9DU

John Radcliffe Hospital, Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY