24
Participants
Start Date
March 31, 2005
Primary Completion Date
December 31, 2007
Study Completion Date
October 31, 2009
Busulfan
130 mg/m\^2 in normal saline over three (3) hours IV every twenty-four (24) hours for four (4) consecutive days (days -7 to -4)
Cyclophosphamide
60 mg/kg in 500 ml of normal saline over 4 hours on each of 2 consecutive days (day -3, -2)
Imatinib Mesylate
Starting dose 100 mg/day (mg/d), escalated to maximal dose of 400 mg/d as tolerated, after day 28 when Absolute neutrophil count (ANC) is \>1500/mcl and platelets \>50,000 /mcl, may be titrated to maintain ANC \>1.0 and platelets \>50,000 /mcl.
Autologous Stem Cell Transplantation
Stem Cell Infusion: Unpurged hematopoietic stem cells administered intravenously on day 0.
UT MD Anderson Cancer Center, Houston
M.D. Anderson Cancer Center
OTHER