A Study to Evaluate the Safety and Immunogenicity of 4 Doses of MenACWY Conjugate Vaccine, Administered Concomitantly With Routine Vaccines, Among Infants Aged 2 Months

PHASE3CompletedINTERVENTIONAL
Enrollment

529

Participants

Timeline

Start Date

November 30, 2009

Primary Completion Date

November 30, 2011

Study Completion Date

November 30, 2011

Conditions
Meningococcal Disease
Interventions
BIOLOGICAL

MenACWY-CRM

One dose (0.5 mL) of MenACWY conjugate vaccine supplied as an extemporaneous mixing just before injection of the lyophilized component (MenA) reconstituted with the liquid component (MenCWY) was administered at 2, 4, 6 and 12 months of age as IM injections in the anterolateral area of the thigh.

BIOLOGICAL

DTaP-IPV/Hib

IM injections of 3 doses of 0.5 mL each of DTaP-IPV/Hib supplied in prefilled vial were administered at 2, 4 and 6 months of age in the anterolateral area of the thigh.

BIOLOGICAL

HBV

IM injections of 3 doses of 0.5 mL each of HBV supplied in prefilled vial were administered at 2, 4 and 6 months of age in the anterolateral area of the thigh.

BIOLOGICAL

PCV

IM injections of 4 doses of 0.5 mL each of PCV supplied in prefilled vial were administered at 2, 4, 6 and 12 months of age in the anterolateral area of the thigh.

BIOLOGICAL

MMR

Subcutaneous (SC) injection of 1 dose of 0.5 mL of MMR obtained by extemporaneous mixing just before injection of powder and the solvent for solution was administered at 12 months of age in the anterolateral area of the thigh.

Trial Locations (46)

2031

3 Sydney Children's Hospital Strasser Lab. Level 3 High Street, Randwick

3010

1 Murdoch Childrens Research Institute C/- School of Population Health The University of Melbourne, Carlton

4029

2 Royal Children's Hospital Herston Road, Herston

15241

33 Primary Physicians Research Inc. 1580 McLaughlin Run Road, Pittsburgh

34 Primary Physicians Research Inc. 1580 McLaughlin Run Road, Pittsburgh

23219

36 Dominion Medical Associates 304 East Leigh Street, Richmond

25304

21 CAMC Health Education and Research Institute 3100 McCorkle Ave. S.E. Suite 806, Charleston

33126

8 Pharmax Research Clinic 7200 NW 7th Street Suite 350, Miami

35235

37 Alabama Clinical Therapeutics LLC 52 Medical Park East Drive Suite 203, Birmingham

37087

23 Focus Research Group 201 Signature Place, Lebanon

37660

10 Holston Medical Group 105 W. Stone Drive Suite 3B, Kingsport

40004

29 Kentucky Pediatric/Adult Research 201 South 5th Street, Bardstown

40069

30 Kentucky Pediatric/Adult Research 102 West Depot Street, Springfield

40291

4 Nassim McMonigle Mescia and Associates 5512 Bardstown Road Suite 2, Louisville

40 Brownsboro Park Pediatrics 5512 Bardstown Road Suite 2, Louisville

40402

24 University Of Louisville 555 South Floyd Street, Louisville

26 University Of Louisville 230 East Broadway, Louisville

45406

5 Dayton Clinical Research 1100 Salem Ave., Dayton

45420

22 Ohio Pediatrics Research Association 1775 Delco Park Drive, Kettering

45424

14 Ohio Pediatrics Research Association 7371 Brandt Pike Suite C, Huber Heights

49120

35 Southwestern Medical Clinic P.C. 2002 S 11th Street, Niles

64114

25 Center for Pharmaceutical Research 1010 Carondelet Drive Suite 426, Kansas City

66604

48 Cotton O'Neil Clinical Research Center 4100 SW 15th Street, Topeka

66614

47 Cotton O'Neil Clinical Research Center 6725 SW 29th Street, Topeka

71037

27 Ark-La-Tex Children's Clinic 1025 Highway 80 E, Haughton

71105

13 Willis Knighton Physician Network- Portico Pediatrics 7847 Youree Drive, Shreveport

72401

6 Children's Clinic of Jonesboro AR 800 South Church Street Suite 400 and 204, Jonesboro

72703

15 Northwest Arkansas Pediatric Clinic 3383 N. Mana Court Suite 101, Fayetteville

74127

45 Oklahoma State University Physicians 635 W 11th St, Tulsa

77070

46 Pediatric Healthcare of Northwest Houston P.A. 12015 Louetta Road Suite 100, Houston

77375

12 Pediatric Healthcare of Northwest Houston P.A. 13406 Medical Complex Drive Suite 200, Tomball

79124

7 Amarillo Children's Clinical Research #17 Care Circle, Amarillo

84015

16 Westside Medical 1477 North 2000 West, Clinton

84041

42 Wee Care Pediatrics 934 S. Main Street Suite 8, Layton

43 Wee Care Pediatrics 1580 W. Antelope Drive Suite 100, Layton

84067

44 Wee Care Pediatrics 5991 S. 3500 W Suite 100 Rock Run Plaza, Roy

84075

41 Wee Care Pediatrics 1792 W. 1700 S. Suite 102, Syracuse

84095

18 Copperview Medical Center 3556 West 9800 South, South Jordan

84604

19 Pediatric Care 1675 North Freedom Blvd Building 3, Provo

84790

39 Dixie Pediatrics 1240 E 100 S Suite 14, St. George

90723

38 Center for Clinical Trials LLC 16660 Paramount Blvd Suite 301, Paramount

91306

9 San Fernando Valley Research Associates 7111 Winnetka Avenue Suite 14, Canoga Park

93637

28 Madera Family Medical Group 1111 West 4th Street, Madera

92708-5153

17 Edinger Medical Group Research Center 9900 Talbert Avenue Suite 204, Fountain Valley

44121-4243

31 Senders Pediatrics 2054 South Green Road, Cleveland

P3E 1H5

20 Medicor Research Inc 359 Riverside Suite 200, Greater Sudbury

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novartis Vaccines

INDUSTRY