38
Participants
Start Date
October 31, 1993
Primary Completion Date
June 30, 2007
Study Completion Date
June 30, 2015
Surgery
Segmentectomy or lobectomy with en bloc resection of the involved chest.
Chest Irradiation
Radiation therapy consists of 60 Gy in 50 fractions for negative margins, or 64.8 Gy in 54 fractions for positive margins, at 1.2 Gy per fraction, 2 fractions per day, 5 days per week.
Cisplatin
50 mg/M\^2 given intravenously on days 1 and 8; the cycle will be repeated beginning on day 29.
Etoposide
given by mouth 30-60 minutes prior to each administration of radiotherapy, on days 1-5 and days 8-12; the cycle will be repeated beginning day 29.
Prophylactic Cranial Irradiation
25 Gy in 10 fractions of 2.5 Gy, 1 fraction per day, will be given at the completion of chest irradiation, and is optional.
University of Texas MD Anderson Cancer Center, Houston
M.D. Anderson Cancer Center
OTHER