Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

October 31, 1993

Primary Completion Date

June 30, 2007

Study Completion Date

June 30, 2015

Conditions
Lung Cancer
Interventions
PROCEDURE

Surgery

Segmentectomy or lobectomy with en bloc resection of the involved chest.

RADIATION

Chest Irradiation

Radiation therapy consists of 60 Gy in 50 fractions for negative margins, or 64.8 Gy in 54 fractions for positive margins, at 1.2 Gy per fraction, 2 fractions per day, 5 days per week.

DRUG

Cisplatin

50 mg/M\^2 given intravenously on days 1 and 8; the cycle will be repeated beginning on day 29.

DRUG

Etoposide

given by mouth 30-60 minutes prior to each administration of radiotherapy, on days 1-5 and days 8-12; the cycle will be repeated beginning day 29.

RADIATION

Prophylactic Cranial Irradiation

25 Gy in 10 fractions of 2.5 Gy, 1 fraction per day, will be given at the completion of chest irradiation, and is optional.

Trial Locations (1)

77030

University of Texas MD Anderson Cancer Center, Houston

All Listed Sponsors
lead

M.D. Anderson Cancer Center

OTHER